Search Result "hit to lead optimization"
Lead Generation - Enhancing the Success of Drug Discovery by Investing in the Hit to Lead Process
Journal: Combinatorial Chemistry & High Throughput Screening
Volume: 6 Issue: 1 Year: 2003 Page: 51-66
Author(s): Alexander Alanine, Matthias Nettekoven, Edward Roberts, Andrew W. Thomas
Novel, Acidic CCR2 Receptor Antagonists: From Hit to Lead
Journal: Letters in Drug Design & Discovery
Volume: 4 Issue: 3 Year: 2007 Page: 185-191
Author(s): D. Zou, H.-X. Zhai, J. Eckman, P. Higgins, M. Gillard, L. Knerr, S. Carre, P. Pasau, P. Collart, J. Grassi
Efficient Optimization Strategy for Marginal Hits Active Against abl Tyrosine Kinases
Journal: Current Drug Discovery Technologies
Volume: 1 Issue: 3 Year: 2004 Page: 201-210
Author(s): Sergey E. Tkachenko, Ilya Okun, Konstantin V. Balakin, Charles E. Petersen, Yan A. Ivanenkov, Nikolay P. Savchuk, Andrey A. Ivashchenko
Novel, Acidic CCR2 Receptor Antagonists: Lead Optimization
Journal: Letters in Drug Design & Discovery
Volume: 4 Issue: 4 Year: 2007 Page: 263-271
Author(s): O. A. Dasse, J. L. Evans, H.-X. Zhai, D. Zou, J. T. Kintigh, F. Chan, K. Hamilton, E. Hill, J. B. Eckman, P. J. Higgins, A. Volosov, P. Collart, J.-M. Nicolas, R.K. Kondru, C.E. Schwartz
The In Silico Drug Discovery Toolbox: Applications in Lead Discovery and Optimization
Journal: Current Medicinal Chemistry
Volume: 26 Issue: 2 Year: 2019 Page: 3838-3873
Author(s): Agostino Bruno,Gabriele Costantino,Luca Sartori,Marco Radi
Linear Interaction Energy (LIE) Method in Lead Discovery and Optimization
Journal: Current Drug Targets
Volume: 9 Issue: 1 Year: 2008 Page: 1100-1105
Author(s): Hermes Luis Neubauer de Amorim, Rafael Andrade Caceres, Paulo Augusto Netz
A Collaborative Hit-to-Lead Investigation Leveraging Medicinal Chemistry Expertise with High Throughput Library Design, Synthesis and Purification Capabilities
Journal: Combinatorial Chemistry & High Throughput Screening
Volume: 9 Issue: 2 Year: 2006 Page: 123-130
Author(s): X. Yang, D. Parker, L. Whitehead, N. S. Ryder, B. Weidmann, M. Stabile-Harris, D. Kizer, M. McKinnon, A. Smellie, D. Powers
Computer-Aided Drug Design: Lead Discovery and Optimization
Journal: Combinatorial Chemistry & High Throughput Screening
Volume: 15 Issue: 4 Year: 2012 Page: 328-337
Author(s): Mingli Xiang, Yu Cao, Wenjie Fan, Lijuan Chen, Yirong Mo
Strategy of Utilizing In Vitro and In Vivo ADME Tools for Lead Optimization and Drug Candidate Selection
Journal: Current Topics in Medicinal Chemistry
Volume: 5 Issue: 1 Year: 2005 Page: 1033-1038
Author(s): Suresh K. Balani, Gerald T. Miwa, Liang-Shang Gan, Jing-Tao Wu, Frank W. Lee
Facts, Figures and Trends in Lead Generation
Journal: Current Topics in Medicinal Chemistry
Volume: 4 Issue: 6 Year: 2004 Page: 569-580
Author(s): Rebecca Deprez-Poulain, Benoit Deprez