Search Result "Unbound Drug Concentration Hypothesis"
Insight into Tissue Unbound Concentration: Utility in Drug Discovery and Development
Journal: Current Drug Metabolism
Volume: 14 Issue: 3 Year: 2013 Page: 324-340
Author(s): T. Thanga Mariappan,Sandhya Mandlekar,Punit Marathe
The Role of Unbound Drug in Pharmacokinetics/Pharmacodynamics and in Therapy
Journal: Current Pharmaceutical Design
Volume: 12 Issue: 8 Year: 2006 Page: 977-987
Author(s): Rosario Calvo, John C. Lukas, Monica Rodriguez, Nerea Leal, Elena Suarez
Do We Need to Optimize Plasma Protein and Tissue Binding in Drug Discovery?
Journal: Current Topics in Medicinal Chemistry
Volume: 11 Issue: 4 Year: 2011 Page: 450-466
Author(s): Xingrong Liu, Cuiping Chen, Cornelis E.C.A. Hop
In Silico Prediction of Brain Exposure: Drug Free Fraction, Unbound Brain to Plasma Concentration Ratio and Equilibrium Half-Life
Journal: Current Topics in Medicinal Chemistry
Volume: 13 Issue: 7 Year: 2013 Page: 813-820
Author(s): Morena Spreafico, Matthew P. Jacobson
CSF as a Surrogate for Assessing CNS Exposure: An Industrial Perspective
Journal: Current Drug Metabolism
Volume: 9 Issue: 1 Year: 2008 Page: 46-59
Author(s): Jiunn H. Lin
Nucleoprotein-Derived and Unbound Ribonucleosides: Bioactivity and Potential Applications
Journal: Current Pharmaceutical Design
Volume: 13 Issue: 9 Year: 2007 Page: 921-932
Author(s): Dierk Martin, Hans Meisel
Evaluation of Human Plasma Protein Binding of Trabectedin (Yondelis™, ET-743)
Journal: Current Clinical Pharmacology
Volume: 4 Issue: 1 Year: 2009 Page: 38-42
Author(s): Jan Handrick Beumer, L. Lopez-Lazaro, Jan H.M. Schellens, Jos H. Beijnen, Olaf van Tellingen
Current State and Future Perspectives in QSAR Models to Predict Blood- Brain Barrier Penetration in Central Nervous System Drug R&D
Journal: Mini-Reviews in Medicinal Chemistry
Volume: 17 Issue: 3 Year: 2017 Page: 247-257
Author(s): Juan F. Morales,Sebastian Scioli Montoto,Pietro Fagiolino,Maria E. Ruiz
Using PET Studies of P-gp Function to Elucidate Mechanisms Underlying the Disposition of Drugs
Journal: Current Topics in Medicinal Chemistry
Volume: 10 Issue: 1 Year: 2010 Page: 1799-1809
Author(s): Stina Syvanen, Margareta Hammarlund-Udenaes
Tissue Distribution and Pharmacodynamics: A Complicated Relationship
Journal: Current Drug Metabolism
Volume: 7 Issue: 1 Year: 2006 Page: 39-65
Author(s): Jiunn H. Lin