Search Result "Time-dependent inhibition (TDI)"


Evaluation of Different Approaches to Identifying a Higher Throughput Assay for Time-Dependent Inhibition (TDI)

Journal: Drug Metabolism Letters
Volume: 5 Issue: 2 Year: 2011 Page: 104-113
Author(s): M. Kajbaf, R. Longhi, S. Fontana

An Examination of IC50 and IC50-Shift Experiments in Assessing Time-Dependent Inhibition of CYP3A4, CYP2D6 and CYP2C9 in Human Liver Microsomes

Journal: Drug Metabolism Letters
Volume: 2 Issue: 1 Year: 2008 Page: 51-59
Author(s): Loren M. Berry, Zhiyang Zhao

Evaluation of Time-Dependent Cytochrome P450 Inhibition in a High-Throughput, Automated Assay: Introducing a Novel Area Under the Curve Shift Approach

Journal: Drug Metabolism Letters
Volume: 6 Issue: 1 Year: 2012 Page: 43-53
Author(s): Sophie Mukadam, Suzanne Tay, Daniel Tran, Leslie Wang, Erlie M. Delarosa, S. Cyrus Khojasteh, Jason S. Halladay, Jane R. Kenny

Higher Throughput Human Hepatocyte Assays for the Evaluation of Time-Dependent Inhibition of CYP3A4

Journal: Drug Metabolism Letters
Volume: 5 Issue: 3 Year: 2011 Page: 183-191
Author(s): Albert P. Li, Utkarsh Doshi

In Vitro Evaluation of Reversible and Time-Dependent Inhibitory Effects of Kalanchoe crenata on CYP2C19 and CYP3A4 Activities

Journal: Drug Metabolism Letters
Volume: 9 Issue: 1 Year: 2015 Page: 48-62
Author(s): Charles Awortwe,Vamshi K. Manda,Cristina Avonto,Shabana I. Khan,Ikhlas A. Khan,Larry A. Walker,Patrick J. Bouic,Bernd Rosenkranz

In Vitro Cytochrome P450 Inhibition and Induction

Journal: Current Drug Metabolism
Volume: 9 Issue: 9 Year: 2008 Page: 928-939
Author(s): Robert L. Walsky, Sherri E. Boldt

Assessment of Cytochrome P450 Enzyme Inhibition and Inactivation in Drug Discovery and Development

Journal: Current Topics in Medicinal Chemistry
Volume: 11 Issue: 4 Year: 2011 Page: 382-403
Author(s): David O. Nettleton, Heidi J. Einolf

CYP Inhibition-Mediated Drug-Drug Interactions

Journal: Current Enzyme Inhibition
Volume: 6 Issue: 3 Year: 2010 Page: 130-145
Author(s): Karoly Tihanyi, Monika L. Bakk, Eva Hellinger, Monika Vastag

Inhibition of Major Drug Metabolizing CYPs by Common Herbal Medicines used by HIV/AIDS Patients in Africa– Implications for Herb- Drug Interactions

Journal: Drug Metabolism Letters
Volume: 7 Issue: 2 Year: 2013 Page: 83-95
Author(s): Charles Awortwe,Patrick J. Bouic,Collen M. Masimirembwa,Bernd Rosenkranz

Methods for Predicting In Vivo Pharmacokinetics Using Data from In Vitro Assays

Journal: Current Drug Metabolism
Volume: 9 Issue: 9 Year: 2008 Page: 940-951
Author(s): J. Brian Houston, Aleksandra Galetin

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