Search Result "P-gp knockout mice"


The Role of P-Glycoprotein in the Pharmacokinetics and Tissue Distribution of a Hepatitis C Virus Protease Inhibitor

Journal: Drug Metabolism Letters
Volume: 3 Issue: 4 Year: 2009 Page: 290-295
Author(s): Kevin X. Chen, Bancha Vibulbhan, Tongtong Liu, Lisa Broske, Genfeng Wang, Cheng Li, F. George Njoroge, Annette S. Uss, K.-C. Cheng

Molecular Mechanisms Underlying Behavioral Effects of Cocaine: Lessons From Knockout Mice

Journal: Current Pharmacogenomics
Volume: 2 Issue: 2 Year: 2004 Page: 185-202
Author(s): F. Scott Hall, Ichiro Sora, George R. Uhl

The Coordinated Role of CYP450 Enzymes and P-gp in Determining Cancer Resistance to Chemotherapy

Journal: Current Drug Metabolism
Volume: 12 Issue: 8 Year: 2011 Page: 713-721
Author(s): Amalia Azzariti, Letizia Porcelli, Anna Elisa Quatrale, Nicola Silvestris, Angelo Paradiso

Modulation and Absorption of Xenobiotics: The Synergistic Role of CYP450 and P-gp Activities in Cancer and Neurodegenerative Disorders

Journal: Current Drug Metabolism
Volume: 12 Issue: 8 Year: 2011 Page: 702-712
Author(s): Carmela Inglese, Maria Grazia Perrone, Francesco Berardi, Roberto Perrone, Nicola Antonio Colabufo

A Simplified Protocol Employing Elacridar in Rodents: A Screening Model in Drug Discovery to Assess P-gp Mediated Efflux at the Blood Brain Barrier

Journal: Drug Metabolism Letters
Volume: 6 Issue: 2 Year: 2012 Page: 134-144
Author(s): Rajareddy Kallem,Chetan P. Kulkarni,Dakshay Patel,Megha Thakur,Michael Sinz,Sheelendra P. Singh,S. Shahe Mahammad,Sandhya Mandlekar

Research Article

Practical Application of Rodent Transporter Knockout Models to AssessBrain Penetration in Drug Discovery

Journal: Drug Metabolism and Bioanalysis Letters
Volume: 15 Issue: 1 Year: 2022 Page: 12-21
Author(s): Christopher R. Jones

Knock-Out Mice in Osteoarthritis Research

Journal: Current Rheumatology Reviews
Volume: 4 Issue: 3 Year: 2008 Page: 183-192
Author(s): Aurelia Raducanu, Attila Aszodi

P-Glycoprotein, but not Multidrug Resistance Protein 4, Plays a Role in the Systemic Clearance of Irinotecan and SN-38 in Mice

Journal: Drug Metabolism Letters
Volume: 4 Issue: 4 Year: 2010 Page: 195-201
Author(s): Michael Tagen, Yanli Zhuang, Fan Zhang, K. Elaine Harstead, Jun Shen, Paula Schaiquevich, Charles H. Fraga, John C. Panetta, Christopher M. Waters, Clinton F. Stewart

Evaluation of Drug Interactions with P-Glycoprotein in Drug Discovery: In Vitro Assessment of the Potential for Drug-Drug Interactions with P-Glycoprotein

Journal: Current Drug Metabolism
Volume: 3 Issue: 3 Year: 2002 Page: 257-273
Author(s): Jerome H. Hochman, Masayo Yamazaki, Tomoyuki Ohe, Jiunn H. Lin

P-Glycoprotein and Breast Cancer Resistance Protein Affect Disposition of Tandutinib, A Tyrosine Kinase Inhibitor

Journal: Drug Metabolism Letters
Volume: 4 Issue: 4 Year: 2010 Page: 202-212
Author(s): Johnny J. Yang, Mark N. Milton, Shaoxia Yu, Mingxiang Liao, Ning Liu, Jing-Tao Wu, Liang-Shang Gan, Suresh K. Balani, Frank W. Lee, Shimoga Prakash, Cindy Q. Xia

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