Search Result "Lead-optimization"


Natural Lead Compounds and Strategies for Optimization

Ebook: Recent Advances in Anesthesiology
Volume: 4 Year: 2018
Author(s): Dev Bukhsh Singh
Doi: 10.2174/97816810844111180401

Advances in the Integration of Drug Metabolism into the Lead Optimization Paradigm

Journal: Mini-Reviews in Medicinal Chemistry
Volume: 9 Issue: 6 Year: 2009 Page: 703-716
Author(s): Walter A. Korfmacher

Linear Interaction Energy (LIE) Method in Lead Discovery and Optimization

Journal: Current Drug Targets
Volume: 9 Issue: 1 Year: 2008 Page: 1100-1105
Author(s): Hermes Luis Neubauer de Amorim, Rafael Andrade Caceres, Paulo Augusto Netz

Computer-Aided Drug Design: Lead Discovery and Optimization

Journal: Combinatorial Chemistry & High Throughput Screening
Volume: 15 Issue: 4 Year: 2012 Page: 328-337
Author(s): Mingli Xiang, Yu Cao, Wenjie Fan, Lijuan Chen, Yirong Mo

Exploring Natural Products as a Source for Antidiabetic Lead Compounds and Possible Lead Optimization

Journal: Current Topics in Medicinal Chemistry
Volume: 16 Issue: 23 Year: 2016 Page: 2549-2561
Author(s): Reema Abu Khalaf

Utility of NMR in Lead Optimization: Fragment-Based Approaches

Journal: Combinatorial Chemistry & High Throughput Screening
Volume: 5 Issue: 8 Year: 2002 Page: 631-643
Author(s): Jeffrey R. Huth, Chaohong Sun

Structure Based Lead Optimization Approach in Discovery of Selective DPP4 Inhibitors

Journal: Mini-Reviews in Medicinal Chemistry
Volume: 13 Issue: 6 Year: 2013 Page: 888-914
Author(s): Manjunath Ghate, Shailesh V. Jain

Application and Utilization of Chemoinformatics Tools in Lead Generation and Optimization

Journal: Combinatorial Chemistry & High Throughput Screening
Volume: 9 Issue: 2 Year: 2006 Page: 95-102
Author(s): N. Fotouhi, P. Gillespie, R. A. Goodnow, S.- S. So, Y. Han, L. E. Babiss

Review Article

The In Silico Drug Discovery Toolbox: Applications in Lead Discovery and Optimization

Journal: Current Medicinal Chemistry
Volume: 26 Issue: 2 Year: 2019 Page: 3838-3873
Author(s): Agostino Bruno,Gabriele Costantino,Luca Sartori,Marco Radi

Methodologies to Assess Brain Drug Delivery in Lead Optimization

Journal: Current Topics in Medicinal Chemistry
Volume: 9 Issue: 2 Year: 2009 Page: 148-162
Author(s): Margareta Hammarlund-Udenaes, Ulf Bredberg, Markus Friden

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