Search Result "tissue unbound drug concentration"


Insight into Tissue Unbound Concentration: Utility in Drug Discovery and Development

Journal: Current Drug Metabolism
Volume: 14 Issue: 3 Year: 2013 Page: 324-340
Author(s): T. Thanga Mariappan,Sandhya Mandlekar,Punit Marathe

Do We Need to Optimize Plasma Protein and Tissue Binding in Drug Discovery?

Journal: Current Topics in Medicinal Chemistry
Volume: 11 Issue: 4 Year: 2011 Page: 450-466
Author(s): Xingrong Liu, Cuiping Chen, Cornelis E.C.A. Hop

The Role of Unbound Drug in Pharmacokinetics/Pharmacodynamics and in Therapy

Journal: Current Pharmaceutical Design
Volume: 12 Issue: 8 Year: 2006 Page: 977-987
Author(s): Rosario Calvo, John C. Lukas, Monica Rodriguez, Nerea Leal, Elena Suarez

Research Article

Liquid Chromatography-Tandem Mass Spectrometry to Monitor Unbound and Total Ceftriaxone in Serum of Critically Ill Patients

Journal: Current Clinical Pharmacology
Volume: 15 Issue: 0 Year: 2020 Page: 1-10
Author(s): Sjoerd Meenks,Jos le Noble,Norbert Foudraine,Frank de Vries,Paddy Janssen

In Silico Prediction of Brain Exposure: Drug Free Fraction, Unbound Brain to Plasma Concentration Ratio and Equilibrium Half-Life

Journal: Current Topics in Medicinal Chemistry
Volume: 13 Issue: 7 Year: 2013 Page: 813-820
Author(s): Morena Spreafico, Matthew P. Jacobson

Methods to Assess Tissue-Specific Distribution and Metabolism of Drugs

Journal: Current Drug Metabolism
Volume: 5 Issue: 6 Year: 2004 Page: 463-481
Author(s): Oliver Langer, Markus Muller

Tissue Distribution and Pharmacodynamics: A Complicated Relationship

Journal: Current Drug Metabolism
Volume: 7 Issue: 1 Year: 2006 Page: 39-65
Author(s): Jiunn H. Lin

CSF as a Surrogate for Assessing CNS Exposure: An Industrial Perspective

Journal: Current Drug Metabolism
Volume: 9 Issue: 1 Year: 2008 Page: 46-59
Author(s): Jiunn H. Lin

The Relevance of Microdialysis for Clinical Oncology

Journal: Current Clinical Pharmacology
Volume: 1 Issue: 3 Year: 2006 Page: 255-263
Author(s): Jos J. E.M.Kitzen, Jaap Verweij, Erik A. C.Wiemer, Walter J. Loos

Nucleoprotein-Derived and Unbound Ribonucleosides: Bioactivity and Potential Applications

Journal: Current Pharmaceutical Design
Volume: 13 Issue: 9 Year: 2007 Page: 921-932
Author(s): Dierk Martin, Hans Meisel

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