Search Result "Unbound Drug Fraction."


The Role of Unbound Drug in Pharmacokinetics/Pharmacodynamics and in Therapy

Journal: Current Pharmaceutical Design
Volume: 12 Issue: 8 Year: 2006 Page: 977-987
Author(s): Rosario Calvo, John C. Lukas, Monica Rodriguez, Nerea Leal, Elena Suarez

Insight into Tissue Unbound Concentration: Utility in Drug Discovery and Development

Journal: Current Drug Metabolism
Volume: 14 Issue: 3 Year: 2013 Page: 324-340
Author(s): T. Thanga Mariappan,Sandhya Mandlekar,Punit Marathe

Research Article

Liquid Chromatography-Tandem Mass Spectrometry to Monitor Unbound and Total Ceftriaxone in Serum of Critically Ill Patients

Journal: Current Clinical Pharmacology
Volume: 15 Issue: 0 Year: 2020 Page: 1-10
Author(s): Sjoerd Meenks,Jos le Noble,Norbert Foudraine,Frank de Vries,Paddy Janssen

In Silico Prediction of Brain Exposure: Drug Free Fraction, Unbound Brain to Plasma Concentration Ratio and Equilibrium Half-Life

Journal: Current Topics in Medicinal Chemistry
Volume: 13 Issue: 7 Year: 2013 Page: 813-820
Author(s): Morena Spreafico, Matthew P. Jacobson

Do We Need to Optimize Plasma Protein and Tissue Binding in Drug Discovery?

Journal: Current Topics in Medicinal Chemistry
Volume: 11 Issue: 4 Year: 2011 Page: 450-466
Author(s): Xingrong Liu, Cuiping Chen, Cornelis E.C.A. Hop

Review Article

A Practical Perspective on the Evaluation of Small Molecule CNS Penetration in Drug Discovery

Journal: Drug Metabolism Letters
Volume: 13 Issue: 2 Year: 2019 Page: 78-94
Author(s): Liyue Huang,Mary C. Wells,Zhiyang Zhao

CSF as a Surrogate for Assessing CNS Exposure: An Industrial Perspective

Journal: Current Drug Metabolism
Volume: 9 Issue: 1 Year: 2008 Page: 46-59
Author(s): Jiunn H. Lin

Fractionation Techniques Improve the Proteomic Analysis of Human Serum

Journal: Current Pharmaceutical Analysis
Volume: 4 Issue: 2 Year: 2008 Page: 69-77
Author(s): Pierluigi Mauri, Andrea Petretto, Davide Cuccabita, Fabrizio Basilico, Dario Di Silvestre, Isabella Levreri, Giovanni Melioli

Review Article

Molecular Modeling Approaches for the Prediction of Selected Pharmacokinetic Properties

Journal: Current Topics in Medicinal Chemistry
Volume: 18 Issue: 26 Year: 2018 Page: 2230-2238
Author(s): Emilio S. Petito,David J.R. Foster,Michael B. Ward,Matthew J. Sykes

The Impact of In Vitro Binding on In Vitro - In Vivo Extrapolations, Projections of Metabolic Clearance and Clinical Drug-Drug Interactions

Journal: Current Drug Metabolism
Volume: 7 Issue: 3 Year: 2006 Page: 251-264
Author(s): K. Grime, R. J. Riley

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