Search Result "Orthosteric ligand binding pocket"


Review Article

Insights into the Structural Aspects of the mGlu Receptor Orthosteric Binding Site

Journal: Current Topics in Medicinal Chemistry
Volume: 19 Issue: 2 Year: 2019 Page: 2421-2446
Author(s): Junliang Hao,Qi Chen

G Protein-Coupled Receptor Transmembrane Binding Pockets and their Applications in GPCR Research and Drug Discovery: A Survey

Journal: Current Topics in Medicinal Chemistry
Volume: 11 Issue: 1 Year: 2011 Page: 1902-1924
Author(s): Nicole A. Kratochwil, Silvia Gatti-McArthur, Marius C. Hoener, Lothar Lindemann, Andreas D. Christ, Luke G. Green, Wolfgang Guba, Rainer E. Martin, Pari Malherbe, Richard H. P. Porter, Jay P. Slack, Marcel Winnig, Henrietta Dehmlow, Uwe Grether, Cornelia Hertel, Robert Narquizian, Constantinos G. Panousis, Sabine Kolczewski, Lucinda Steward

Druggable Orthosteric and Allosteric Hot Spots to Target Protein-protein Interactions

Journal: Current Pharmaceutical Design
Volume: 20 Issue: 8 Year: 2014 Page: 1293-1301
Author(s): Buyong Ma, Ruth Nussinov

The Therapeutic Potential of Allosteric Ligands for Free Fatty Acid Sensitive GPCRs

Journal: Current Topics in Medicinal Chemistry
Volume: 13 Issue: 1 Year: 2013 Page: 14-25
Author(s): Brian D. Hudson, Trond Ulven, Graeme Milligan

The Different Ways through Which Specificity Works in Orthosteric and Allosteric Drugs

Journal: Current Pharmaceutical Design
Volume: 18 Issue: 9 Year: 2012 Page: 1311-1316
Author(s): Ruth Nussinov, Chung-Jung Tsai

A Hydrazide Linker Strategy for Heterobivalent Compounds as Ortho- and Allosteric Ligands of Acetylcholine-Binding Proteins

Journal: Current Topics in Medicinal Chemistry
Volume: 11 Issue: 2 Year: 2011 Page: 2731-2748
Author(s): Paul W. Elsinghorst, Wolfgang Hartig, Daniela Gundisch, Klaus Mohr, Christian Trankle, Michael Gutschow

Research Article

In Silico Identification of Novel Orthosteric Inhibitors of Sphingosine Kinase 1 (SK1)

Journal: Current Protein & Peptide Science
Volume: 19 Issue: 5 Year: 2018 Page: 430-444
Author(s): Ozge Bayraktar,Elif Ozkirimli,Kutlu O. Ulgen

Ligand-Gated Pentameric ion Channels, from Binding to Gating

Journal: Current Molecular Pharmacology
Volume: 2 Issue: 3 Year: 2009 Page: 253-262
Author(s): Gabor Maksay

Glutamate Binding-Site Ligands of NMDA Receptors

Journal: Current Medicinal Chemistry
Volume: 18 Issue: 3 Year: 2011 Page: 5483-5506
Author(s): C. Bonaccorso, N. Micale, R. Ettari, S. Grasso, M. Zappala

Ligand-Based Peptide Design and Combinatorial Peptide Libraries to Target G Protein-Coupled Receptors

Journal: Current Pharmaceutical Design
Volume: 16 Issue: 2 Year: 2010 Page: 3071-3088
Author(s): Christian W. Gruber, Markus Muttenthaler, Michael Freissmuth

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