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Synthesis of the Alzheimer Drug Posiphen into its Primary Metabolic Products (+)-N1-norPosiphen, (+)-N8-norPosiphen and (+)-N1, N8-bisnorPosiphen, their Inhibition of Amyloid Precursor Protein, α -Synuclein Synthesis, Interleukin-1β Release, and Cholinergic Action.

Journal: Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry
Volume: 12 Issue: 2 Year: 2013 Page: 117-128
Author(s): Qian-sheng Yu, Marcella Reale, Mohammad A. Kamal, Harold W. Holloway, Weiming Luo, Kumar Sambamurti, Balmiki Ray, Debomoy K. Lahiri, Jack T. Rogers, Nigel H. Greig