Search Result "Mechanism-based enzyme inactivators"
Oxypeucedanin is a Mechanism-based Inactivator of CYP2B6 and CYP2D6
Journal: Current Drug Metabolism
Volume: 22 Issue: 11 Year: 2021 Page: 882-892
Author(s): Kehan Zhang,Yilin Li,Yao Fu,Tiantian Cui,Qian Wang,Xu Mao,Ying Peng,Jiang Zheng
Mechanism-Based Inactivation of Cytochrome P450 Enzymes: Chemical Mechanisms, Structure-Activity Relationships and Relationship to Clinical Drug-Drug Interactions and Idiosyncratic Adverse Drug Reactions
Journal: Current Drug Metabolism
Volume: 8 Issue: 5 Year: 2007 Page: 407-447
Author(s): Amit S. Kalgutkar, R. Scott Obach, Tristan S. Maurer
Molecular Analysis and Modeling of Inactivation of Human CYP2D6 by Four Mechanism Based Inactivators
Journal: Drug Metabolism Letters
Volume: 6 Issue: 1 Year: 2012 Page: 7-14
Author(s): Mara Livezey, Leslie D. Nagy, Laura E. Diffenderfer, Evan J. Arthur, David J. Hsi, Jeffrey M. Holton, Laura Lowe Furge
Impact of Time-Dependent Inactivation on the Estimation of Enzyme Kinetic Parameters for Midazolam
Journal: Drug Metabolism Letters
Volume: 3 Issue: 1 Year: 2009 Page: 45-53
Author(s): Craig Giragossian, Jennifer LaPerle, Rachel E. Kosa, Sarah Gillian
Mechanism-Based Inactivators as Probes of Cytochrome P450 Structure and Function
Journal: Current Drug Metabolism
Volume: 2 Issue: 3 Year: 2001 Page: 215-243
Author(s): Ute M. Kent, Monica I. Jushchhyshyn, Paul F. Hollenberg
Integrating In Vitro Kinetic Data from Compounds Exhibiting Induction, Reversible Inhibition and Mechanism-Based Inactivation: In Vitro Study Design
Journal: Current Drug Metabolism
Volume: 5 Issue: 2 Year: 2004 Page: 141-146
Author(s): Donavon J. McConn, Zhiyang Zhao
Assessment of Cytochrome P450 Enzyme Inhibition and Inactivation in Drug Discovery and Development
Journal: Current Topics in Medicinal Chemistry
Volume: 11 Issue: 4 Year: 2011 Page: 382-403
Author(s): David O. Nettleton, Heidi J. Einolf
Cytochrome P450 Enzymes Mechanism Based Inhibitors: Common Sub-Structures and Reactivity
Journal: Current Drug Metabolism
Volume: 6 Issue: 5 Year: 2005 Page: 413-451
Author(s): E. Fontana, P. M. Dansette, S. M. Poli
Prediction of Drug-Drug Interactions Arising From Mechanism-Based Inactivation: Key Input Parameters and Impact on Risk Assessment
Journal: Current Drug Metabolism
Volume: 12 Issue: 9 Year: 2011 Page: 871-890
Author(s): Simon G. Wong
High Throughput Quantitative Assessment of CYP Inactivation Using 2 Concentration Points
Journal: Drug Metabolism Letters
Volume: 3 Issue: 2 Year: 2009 Page: 78-82
Author(s): Daniel Albaugh, Thomas Farrell, Michael Langan, W. George Lai