Abstract
Macrocyclic lactones (MLs), exemplified by the prototype of the class, ivermectin (IVM), are mainstays of programs for the control of nematode and arthropod parasites and pests. Since their introduction 30 years ago, research has revealed that they act on a family of ligand-gated chloride channels gated by glutamate, which is largely restricted to animals in the phyla Nematoda and Arthropoda. Studies on IVM in model organisms have contributed greatly to our understanding of ML pharmacology, but our understanding of the basis for differences among species and among MLs in potency and spectrum remains far from complete.
Keywords: Nematode, parasite, arthropod, glutamate-gated chloride channel, ivermectin
Current Pharmaceutical Biotechnology
Title:Macrocyclic Lactone Anthelmintics: Spectrum of Activity and Mechanism of Action
Volume: 13 Issue: 6
Author(s): Timothy G. Geary and Yovany Moreno
Affiliation:
Keywords: Nematode, parasite, arthropod, glutamate-gated chloride channel, ivermectin
Abstract: Macrocyclic lactones (MLs), exemplified by the prototype of the class, ivermectin (IVM), are mainstays of programs for the control of nematode and arthropod parasites and pests. Since their introduction 30 years ago, research has revealed that they act on a family of ligand-gated chloride channels gated by glutamate, which is largely restricted to animals in the phyla Nematoda and Arthropoda. Studies on IVM in model organisms have contributed greatly to our understanding of ML pharmacology, but our understanding of the basis for differences among species and among MLs in potency and spectrum remains far from complete.
Export Options
About this article
Cite this article as:
G. Geary Timothy and Moreno Yovany, Macrocyclic Lactone Anthelmintics: Spectrum of Activity and Mechanism of Action, Current Pharmaceutical Biotechnology 2012; 13 (6) . https://dx.doi.org/10.2174/138920112800399077
DOI https://dx.doi.org/10.2174/138920112800399077 |
Print ISSN 1389-2010 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4316 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Why and how do Microbubbles Enhance the Effectiveness of Diagnostic and Therapeutic Interventions in Cerebrovascular Disease?
Current Pharmaceutical Design Targeting Glutamatergic Signaling for the Development of Novel Therapeutics for Mood Disorders
Current Pharmaceutical Design Development and Validation of a Fluorescence-Based HTS Assay for the Identification of P/Q-Type Calcium Channel Blockers
Combinatorial Chemistry & High Throughput Screening Targeting Mitochondria in Fighting Cancer
Current Pharmaceutical Design Interplay between Catalysts and Substrates for Activity of Class Ib Aminoacyl-tRNA Synthetases and Implications for Pharmacology
Current Topics in Medicinal Chemistry The Role of Neuronal Insulin/Insulin-Like Growth Factor-1 Signaling for the Pathogenesis of Alzheimer’s Disease: Possible Therapeutic Implications
CNS & Neurological Disorders - Drug Targets Inhibitors of Cyclin-Dependent Kinases: Potential Drugs for the Treatment of Neurodegenerative Disorders?
Current Medicinal Chemistry - Central Nervous System Agents Metabotropic Glutamate Receptors as Targets for Analgesia: Antagonism, Activation, and Allosteric Modulation
Current Pharmaceutical Biotechnology Physiological and Morphological Principles Underpinning Recruitment of the Cerebellar Reserve
CNS & Neurological Disorders - Drug Targets 5-HT2 Receptors
Current Drug Targets - CNS & Neurological Disorders Molecular Genetics and Biomarkers of Polyglutamine Diseases
Current Molecular Medicine Sphingolipids in Cell Signaling: Their Function as Receptor Ligands, Second Messengers, and Raft Constituents
Current Immunology Reviews (Discontinued) The Learning-based Automatic Segmentation Algorithm of Brain MR Images Based on 7T
Current Medical Imaging An Overall Picture of Chemokine Receptors: Basic Research and Drug Development
Current Pharmaceutical Design Brain Connectivity Networks in Schizophrenia Underlying Resting State Functional Magnetic Resonance Imaging
Current Topics in Medicinal Chemistry Silencing the Brain May be Better than Stimulating it. The GABA Effect
Current Pharmaceutical Design Synthetic Glucocorticoids: Antenatal Administration and Long-term Implications
Current Pharmaceutical Design HCN Channels Modulators: The Need for Selectivity
Current Topics in Medicinal Chemistry P2X7 Receptor-Associated Programmed Cell Death in the Pathophysiology of Hemorrhagic Stroke
Current Neuropharmacology Acetylcholinesterase Inhibition in Alzheimers Disease
Current Pharmaceutical Design