Drug Targets in Infections with Ebola and Marburg Viruses

Olinger   G.   Gene; Biggins   E.   Julia; Melanson   R.   Vanessa; Wahl-Jensen      Victoria; Geisbert   W.   Thomas; Hensley   E.   Lisa

doi:10.2174/187152609787847730

Abstract

The development of antiviral drugs for Ebola and Marburg viruses has been slow. To date, beyond supportive care, no effective treatments, prophylactic measures, therapies, or vaccines are approved to treat or prevent filovirus infections. In this review, we examine the current treatments available to administer care for filovirus infection, the potential therapeutic targets that can be used for filovirus drug development, and the various drug targeting techniques used against filoviruses.

Keywords: Filoviridae, Ebola virus, Marburg virus, drug targets, therapeutics, pathogenesis, pathology, immunotherapy