Abstract
Vanadate can be bioequivalent to phosphate and replace it in cellular metabolism. The detection of insulin-like activity has spurred interest in the development of oral anti-diabetic drugs containing vanadium. We collected and evaluated a vast toxicity data set and discussed molecular aspects related to insulin-mimetic effects of vanadium complexes.
Keywords: vanadium, anti-diabetic, insulin-mimetic, phospho-mimetic, ptp-1b, toxicity, molecular design
Mini-Reviews in Medicinal Chemistry
Title: Are Vanadium Compounds Drugable? Structures and Effects of Antidiabetic Vanadium Compounds: A Critical Review
Volume: 5 Issue: 11
Author(s): Thomas Scior, Antonio Guevara-Garcia, Philippe Bernard, Quoc-Tuan Do, David Domeyer and Stefan Laufer
Affiliation:
Keywords: vanadium, anti-diabetic, insulin-mimetic, phospho-mimetic, ptp-1b, toxicity, molecular design
Abstract: Vanadate can be bioequivalent to phosphate and replace it in cellular metabolism. The detection of insulin-like activity has spurred interest in the development of oral anti-diabetic drugs containing vanadium. We collected and evaluated a vast toxicity data set and discussed molecular aspects related to insulin-mimetic effects of vanadium complexes.
Export Options
About this article
Cite this article as:
Scior Thomas, Guevara-Garcia Antonio, Bernard Philippe, Do Quoc-Tuan, Domeyer David and Laufer Stefan, Are Vanadium Compounds Drugable? Structures and Effects of Antidiabetic Vanadium Compounds: A Critical Review, Mini-Reviews in Medicinal Chemistry 2005; 5 (11) . https://dx.doi.org/10.2174/138955705774575264
DOI https://dx.doi.org/10.2174/138955705774575264 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Neurodegeneration and Neuroprotection in Multiple Sclerosis
Current Pharmaceutical Design Current Research Issues in the Pharmacokinetics of Antiretroviral Drugs in Children
Current Pediatric Reviews Clinical Determination of the Severity of Metabolic Syndrome: Preheparin Lipoprotein Lipase Mass as a New Marker of Metabolic Syndrome
Current Medicinal Chemistry - Cardiovascular & Hematological Agents Drug Target Identification for Neuronal Apoptosis Through a Genome Scale Screening
Current Medicinal Chemistry Endothelin-1 Actions on Vascular Smooth Muscle Cell Functions As a Target for the Prevention of Atherosclerosis
Current Vascular Pharmacology Editorial [Hot topic: Proteinuria in Diabetes: an Endocrine Disease? (Guest Editor: Alessia Fornoni and Oliver Lenz)]
Current Diabetes Reviews Polymeric Materials and Formulation Technologies for Modified-Release Tablet Development
Mini-Reviews in Medicinal Chemistry The First Line of Defense Against Cardiac Hypertrophy
Current Molecular Medicine Cholecystokinin 1(A) Receptor Polymorphisms
Current Topics in Medicinal Chemistry Dendritic Cells and Immunomodulation: Role in Health and Disease
Current Immunology Reviews (Discontinued) Glucocorticoids, the Etiology of Obesity and the Metabolic Syndrome
Current Alzheimer Research Lysophospholipids: Their Generation, Physiological Role and Detection. Are They Important Disease Markers?
Mini-Reviews in Medicinal Chemistry The Need for Calcium Channels in Cell Proliferation
Recent Patents on Anti-Cancer Drug Discovery Genomics and Natural Products: Role of Bioinformatics and Recent Patents
Recent Patents on Biotechnology Effects of the Novel Non-Peptidyl Low Molecular Weight Radical Scavenger IAC in Different Models of Inflammation: A New Perspective in Anti-Inflammatory Therapy
Current Medicinal Chemistry Targeting Aldose Reductase for the Treatment of Cancer
Current Cancer Drug Targets Circadian Cycle and Chronotherapeutics: Recent Trend for the Treatment of Various Biological Disorders
Recent Patents on Drug Delivery & Formulation Recent Developments in the Search for Biomarkers for the Diagnosis and Monitoring of Diabetes
Recent Patents on Endocrine, Metabolic & Immune Drug Discovery (Discontinued) Synthesis, Characterization and Evaluation of Gemfibrozil-Stilbene Hybrid as Antioxidant Agent
Letters in Drug Design & Discovery Growing Collateral Arteries On Demand
Recent Patents on Cardiovascular Drug Discovery