Abstract
Vanadate can be bioequivalent to phosphate and replace it in cellular metabolism. The detection of insulin-like activity has spurred interest in the development of oral anti-diabetic drugs containing vanadium. We collected and evaluated a vast toxicity data set and discussed molecular aspects related to insulin-mimetic effects of vanadium complexes.
Keywords: vanadium, anti-diabetic, insulin-mimetic, phospho-mimetic, ptp-1b, toxicity, molecular design
Mini-Reviews in Medicinal Chemistry
Title: Are Vanadium Compounds Drugable? Structures and Effects of Antidiabetic Vanadium Compounds: A Critical Review
Volume: 5 Issue: 11
Author(s): Thomas Scior, Antonio Guevara-Garcia, Philippe Bernard, Quoc-Tuan Do, David Domeyer and Stefan Laufer
Affiliation:
Keywords: vanadium, anti-diabetic, insulin-mimetic, phospho-mimetic, ptp-1b, toxicity, molecular design
Abstract: Vanadate can be bioequivalent to phosphate and replace it in cellular metabolism. The detection of insulin-like activity has spurred interest in the development of oral anti-diabetic drugs containing vanadium. We collected and evaluated a vast toxicity data set and discussed molecular aspects related to insulin-mimetic effects of vanadium complexes.
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Cite this article as:
Scior Thomas, Guevara-Garcia Antonio, Bernard Philippe, Do Quoc-Tuan, Domeyer David and Laufer Stefan, Are Vanadium Compounds Drugable? Structures and Effects of Antidiabetic Vanadium Compounds: A Critical Review, Mini-Reviews in Medicinal Chemistry 2005; 5 (11) . https://dx.doi.org/10.2174/138955705774575264
DOI https://dx.doi.org/10.2174/138955705774575264 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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