Abstract
Membrane bound P-glycoprotein (Pgp) acts as an active transport pump. It plays a major role as a cause of multidrug resistance (MDR) and acts as a component of the blood-brain barrier. Pgp transports a wide variety of structurally unrelated compound from the cell interior into the extracellular space. Recent molecular modeling efforts, mostly in homology modeling and QSAR studies, have brought some understanding to the interactions between the protein and the drugs at the atomic level. We review the recent developments from the point of view of methodology.
Keywords: multidrug resistance, nucleotide binding domain, QSAR methods, transmembrane regions, ATP hydrolysis
Current Topics in Medicinal Chemistry
Title: Mini Review on Molecular Modeling of P-Glycoprotein (Pgp)
Volume: 7 Issue: 15
Author(s): Sookhee N. Ha, Jerome Hochman and Robert P. Sheridan
Affiliation:
Keywords: multidrug resistance, nucleotide binding domain, QSAR methods, transmembrane regions, ATP hydrolysis
Abstract: Membrane bound P-glycoprotein (Pgp) acts as an active transport pump. It plays a major role as a cause of multidrug resistance (MDR) and acts as a component of the blood-brain barrier. Pgp transports a wide variety of structurally unrelated compound from the cell interior into the extracellular space. Recent molecular modeling efforts, mostly in homology modeling and QSAR studies, have brought some understanding to the interactions between the protein and the drugs at the atomic level. We review the recent developments from the point of view of methodology.
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Cite this article as:
Ha N. Sookhee, Hochman Jerome and Sheridan P. Robert, Mini Review on Molecular Modeling of P-Glycoprotein (Pgp), Current Topics in Medicinal Chemistry 2007; 7 (15) . https://dx.doi.org/10.2174/156802607782194806
DOI https://dx.doi.org/10.2174/156802607782194806 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
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