Abstract
Membrane bound P-glycoprotein (Pgp) acts as an active transport pump. It plays a major role as a cause of multidrug resistance (MDR) and acts as a component of the blood-brain barrier. Pgp transports a wide variety of structurally unrelated compound from the cell interior into the extracellular space. Recent molecular modeling efforts, mostly in homology modeling and QSAR studies, have brought some understanding to the interactions between the protein and the drugs at the atomic level. We review the recent developments from the point of view of methodology.
Keywords: multidrug resistance, nucleotide binding domain, QSAR methods, transmembrane regions, ATP hydrolysis
Current Topics in Medicinal Chemistry
Title: Mini Review on Molecular Modeling of P-Glycoprotein (Pgp)
Volume: 7 Issue: 15
Author(s): Sookhee N. Ha, Jerome Hochman and Robert P. Sheridan
Affiliation:
Keywords: multidrug resistance, nucleotide binding domain, QSAR methods, transmembrane regions, ATP hydrolysis
Abstract: Membrane bound P-glycoprotein (Pgp) acts as an active transport pump. It plays a major role as a cause of multidrug resistance (MDR) and acts as a component of the blood-brain barrier. Pgp transports a wide variety of structurally unrelated compound from the cell interior into the extracellular space. Recent molecular modeling efforts, mostly in homology modeling and QSAR studies, have brought some understanding to the interactions between the protein and the drugs at the atomic level. We review the recent developments from the point of view of methodology.
Export Options
About this article
Cite this article as:
Ha N. Sookhee, Hochman Jerome and Sheridan P. Robert, Mini Review on Molecular Modeling of P-Glycoprotein (Pgp), Current Topics in Medicinal Chemistry 2007; 7 (15) . https://dx.doi.org/10.2174/156802607782194806
DOI https://dx.doi.org/10.2174/156802607782194806 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |

- Author Guidelines
- Bentham Author Support Services (BASS)
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Vascular Toxicity of Chemotherapeutic Agents
Current Vascular Pharmacology More Effective DPP4 Inhibitors as Antidiabetics Based on Sitagliptin Applied QSAR and Clinical Methods
Current Computer-Aided Drug Design Endothelial Dysfunction and Atherosclerosis: Focus on Novel Therapeutic Approaches
Recent Patents on Cardiovascular Drug Discovery Prevention of Allergic Disease Development and Symptoms by Food Factors
Current Pharmaceutical Design Cyclodepsipeptides - Potential Drugs and Lead Compounds in the Drug Development Process
Current Medicinal Chemistry Recent Achievements on Siderophore Production and Application
Recent Patents on Biotechnology New Molecular Targets of Anticancer Therapy – Current Status and Perspectives
Current Medicinal Chemistry Discovery of Novel Scaffolds for Rho Kinase 2 Inhibitor Through TRFRET- Based High Throughput Screening Assay
Combinatorial Chemistry & High Throughput Screening Cascade Reaction in the Synthesis of Heterocyclic Natural Products
Current Organic Chemistry Lysophospholipids: Synthesis and Biological Aspects
Current Organic Chemistry Synthesis of Dihydropyridines: Patented Catalysts and Biological Applications
Recent Patents on Catalysis (Discontinued) Sirtuins: Novel Players in Male Reproductive Health
Current Medicinal Chemistry Roles of p38-MAPK in Insulin Resistant Heart: Evidence from Bench to Future Bedside Application
Current Pharmaceutical Design Novel Agents in the Management of Lung Cancer
Current Medicinal Chemistry Protease-Activated Receptors (PARs) are Partly Pro-Inflammatory and Partly Anti-Inflammatory: Will PAR Agonists or Antagonists Participate in Future Drug Therapies?
Current Drug Targets Review in Pharmacokinetic Models on Corticosteroids
Mini-Reviews in Medicinal Chemistry Therapeutic Agents Based on DNA Sequence Specific Binding
Current Topics in Medicinal Chemistry QSAR of Pyrazole Oxadiazole Derivatives as s1p1 Agonists Studied by CoMFA, CoMSIA and Docking
Letters in Drug Design & Discovery CRF Receptor Antagonists: Utility in Research and Clinical Practice
Current Medicinal Chemistry The Pollen Enigma: Modulation of the Allergic Immune Response by Non-Allergenic, Pollen-Derived Compounds
Current Pharmaceutical Design