Abstract
It was conducted a systematic review of economic evaluations that assessed the cost-effectiveness of interventions to enhance the medication adherence in psychiatric patients. Several bibliographic databases were searched: MEDLINE, MEDLINE in process, PSYCINFO, EMBASE, Cochrane Controlled Trials Register, CINAHL, CRD, EconLit, Science Citation Index and Social Science Citation Index. Full economic evaluations which assessed interventions to enhance the adherence to drug therapy in adult patients with a mental illness were included. Data were extracted and the methodological quality of selected studies was assessed. The information was synthesized through narrative procedures. Four clinical trials and two ongoing studies fulfilled the selection criteria. Two studies did not find significant differences in adherence between the interventions (a compliance-enhancing program, a therapeutic drug monitoring and a pharmacy-based intervention) and the control groups; one study found that a compliance program was more effective than a non-specific counselling intervention over 18 months in psychotic patients; another study found better results in terms of adherence among high-severity depressed patients receiving a stepped collaborative care during 12 months in comparison to a control group; in moderate-severity patients the differences disappeared after the first 6 months. None of the four studies found significant differences in costs between groups because of the low statistical power. In summary, adherence enhancing programs could be cost-effective in psychiatric patients although this statement is based on few studies with limited methodological quality. It is necessary more and better research on the costeffectiveness of interventions in the field of mental health.
Keywords: Cost-effectiveness, depression, medication adherence, patient compliance, psychosis, review, schizophrenia, methodological limitations, psychologist
Current Clinical Pharmacology
Title: Cost-Effectiveness of Interventions to Enhance Medication Adherence in Psychiatric Patients: A Systematic Review
Volume: 6 Issue: 2
Author(s): Lidia Garcia-Perez and Pedro Serrano-Aguilar
Affiliation:
Keywords: Cost-effectiveness, depression, medication adherence, patient compliance, psychosis, review, schizophrenia, methodological limitations, psychologist
Abstract: It was conducted a systematic review of economic evaluations that assessed the cost-effectiveness of interventions to enhance the medication adherence in psychiatric patients. Several bibliographic databases were searched: MEDLINE, MEDLINE in process, PSYCINFO, EMBASE, Cochrane Controlled Trials Register, CINAHL, CRD, EconLit, Science Citation Index and Social Science Citation Index. Full economic evaluations which assessed interventions to enhance the adherence to drug therapy in adult patients with a mental illness were included. Data were extracted and the methodological quality of selected studies was assessed. The information was synthesized through narrative procedures. Four clinical trials and two ongoing studies fulfilled the selection criteria. Two studies did not find significant differences in adherence between the interventions (a compliance-enhancing program, a therapeutic drug monitoring and a pharmacy-based intervention) and the control groups; one study found that a compliance program was more effective than a non-specific counselling intervention over 18 months in psychotic patients; another study found better results in terms of adherence among high-severity depressed patients receiving a stepped collaborative care during 12 months in comparison to a control group; in moderate-severity patients the differences disappeared after the first 6 months. None of the four studies found significant differences in costs between groups because of the low statistical power. In summary, adherence enhancing programs could be cost-effective in psychiatric patients although this statement is based on few studies with limited methodological quality. It is necessary more and better research on the costeffectiveness of interventions in the field of mental health.
Export Options
About this article
Cite this article as:
Garcia-Perez Lidia and Serrano-Aguilar Pedro, Cost-Effectiveness of Interventions to Enhance Medication Adherence in Psychiatric Patients: A Systematic Review, Current Clinical Pharmacology 2011; 6 (2) . https://dx.doi.org/10.2174/157488411796151147
DOI https://dx.doi.org/10.2174/157488411796151147 |
Print ISSN 1574-8847 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3938 |
Related Articles
-
Autoantibodies in Autoimmune Diseases
Current Pharmaceutical Design Antimicrobial and Anti-MRSA Effects of Three Extracts of Some Hypericum Species Against Standard Microorganisms and Methicillin Resistant Staphylococcus aureus (MRSA) Strains
Current Bioactive Compounds Hematopoietic Stem Cell Transplantation for the Treatment of Autoimmunity in Type 1 Diabetes
Current Stem Cell Research & Therapy Binding Site Detection and Druggability Prediction of Protein Targets for Structure- Based Drug Design
Current Pharmaceutical Design Pediatric Cutaneous Graft Versus Host Disease: A Review
Current Pediatric Reviews Patterns of Acute Intracranial Hemorrhage in Adult Patients with Bilateral and Unilateral Moyamoya Disease
Current Neurovascular Research Polymeric Nanocarriers: A New Horizon for the Effective Management of Breast Cancer
Current Pharmaceutical Design Depression and Quality of Life in Patients with Diabetes: A Systematic Review from the European Depression in Diabetes (EDID) Research Consortium
Current Diabetes Reviews Comparison of Changes in Cognitive Functions of Post-stroke Patients with the Computer-based Cognitive Intervention (PABLO System) and Conventional Cognitive Intervention (Paper-pencil Method)
Current Psychiatry Research and Reviews Cytochrome P450 Drug Metabolizing Enzymes in Roma Population Samples: Systematic Review of the Literature
Current Medicinal Chemistry Sleep Spindle Analysis on Typically Developing and Autistic Children During Sedation
Neuroscience and Biomedical Engineering (Discontinued) Effects of Metabolic Approach in Diabetic Patients with Coronary Artery Disease
Current Pharmaceutical Design Heparanase: Structure, Biological Functions, and Inhibition by Heparin-Derived Mimetics of Heparan Sulfate
Current Pharmaceutical Design Nanosuspension Technology: A Strategic Approach for Poorly Soluble Drugs
Nanoscience & Nanotechnology-Asia Therapies in Development for Non-Infectious Uveitis
Current Molecular Medicine Nicotine Effects, Body Weight Concerns and Smoking: A Literature Review
Current Pharmaceutical Design Sex Steroids Regulation of Appetitive Behavior
Mini-Reviews in Medicinal Chemistry Pharmacologic Therapy in Growth Hormone Disorders and the Heart
Current Medicinal Chemistry The Alcohol Hangover Research Group Consensus Statement on Best Practice in Alcohol Hangover Research
Current Drug Abuse Reviews Role of Peroxynitrite in the Cardiovascular Dysfunction of Septic Shock
Current Vascular Pharmacology