Abstract
A nonapeptide, H-Asn-Gln-Trp-Ala-Val-Gly-His-Leu-Met-NH2 , corresponding to amino acids 6 to 14 of bombesin and its four analogues were synthesized by a solid-phase method and were tested for their comparative effect on reducing activity on food intake using male Wistar rats. The synthetic bombesin-fragment6- 14 showed reducing effect on food intake using male Wistar rats. Of the synthetic analogues, [Phe(4F)13 ]bombesin-fragment6-14 exhibited the most potent effect. The reducing effect on food intake of [Sar 11 ]bombesin-fragment6-14 was lower than that of our synthetic bombesin-fragment6-14, but the other two analogues, [beta Ala11]bombesin-fragment6-14 and [1-Nal8 ]bombesin-fragment6-14 showed no reducing effect on food intake in rats.
Keywords: Bombesin-Fragment6-14, Food Intake, nonapeptide, H-Asn-Gln-Trp-Ala-Val-Gly-His-Leu-Met-NH2, SOLID-PHASE PEPTIDE SYNTHESIS
Current Pharmaceutical Biotechnology
Title: Syntheses and Effect of Bombesin-Fragment6-14 and its Four Analogues on Food Intake in Rats
Volume: 2 Issue: 2
Author(s): T. Abiko and Y. Kimura
Affiliation:
Keywords: Bombesin-Fragment6-14, Food Intake, nonapeptide, H-Asn-Gln-Trp-Ala-Val-Gly-His-Leu-Met-NH2, SOLID-PHASE PEPTIDE SYNTHESIS
Abstract: A nonapeptide, H-Asn-Gln-Trp-Ala-Val-Gly-His-Leu-Met-NH2 , corresponding to amino acids 6 to 14 of bombesin and its four analogues were synthesized by a solid-phase method and were tested for their comparative effect on reducing activity on food intake using male Wistar rats. The synthetic bombesin-fragment6- 14 showed reducing effect on food intake using male Wistar rats. Of the synthetic analogues, [Phe(4F)13 ]bombesin-fragment6-14 exhibited the most potent effect. The reducing effect on food intake of [Sar 11 ]bombesin-fragment6-14 was lower than that of our synthetic bombesin-fragment6-14, but the other two analogues, [beta Ala11]bombesin-fragment6-14 and [1-Nal8 ]bombesin-fragment6-14 showed no reducing effect on food intake in rats.
Export Options
About this article
Cite this article as:
Abiko T. and Kimura Y., Syntheses and Effect of Bombesin-Fragment6-14 and its Four Analogues on Food Intake in Rats, Current Pharmaceutical Biotechnology 2001; 2 (2) . https://dx.doi.org/10.2174/1389201013378752
DOI https://dx.doi.org/10.2174/1389201013378752 |
Print ISSN 1389-2010 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4316 |

- Author Guidelines
- Bentham Author Support Services (BASS)
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
C-Peptide and its Correlation to Parameters of Insulin Resistance in the Metabolic Syndrome
CNS & Neurological Disorders - Drug Targets Soluble Forms of RAGE in Human Diseases: Clinical and Therapeutical Implications
Current Medicinal Chemistry The Role of Nuclear Receptor PPARα in the Sleep-wake Cycle Modulation. A Tentative Approach for Treatment of Sleep Disorders
Current Drug Delivery Peroxynitrite-Driven Mechanisms in Diabetes and Insulin Resistance – the Latest Advances
Current Medicinal Chemistry Aptamers as Tools to Study Dysfunction in the Neuronal System
Current Medicinal Chemistry - Central Nervous System Agents Atherosclerosis as an Inflammatory Disease
Current Pharmaceutical Design Expression and Purification of Exendin-4 Dimer in Escherichia coli and Its Interaction with GLP-1 Receptor In Vitro
Protein & Peptide Letters Experience with Androgen Deprivation Therapy for Prostate Cancer in Japan and Future Perspectives
Current Cancer Drug Targets Cannabinoid Receptor G Protein-Coupling and Inverse Agonism
Current Neuropharmacology Correlation Between White Blood Cell Count and Insulin Resistance in Type 2 Diabetes
Current Diabetes Reviews The Role of Integrin-Mediated Cell Adhesion in Atherosclerosis: Pathophysiology and Clinical Opportunities
Current Pharmaceutical Design Reconstituted High Density Lipoprotein-Based Nanoparticles: an Overview of Applications in Regenerative Medicine, Preparation, Evaluation and Future Trends
Current Pharmaceutical Design Effect of Simvastatin use on Autonomic Function in Patients with End Stage Renal Disease
Cardiovascular & Hematological Disorders-Drug Targets Oxaliplapin and Capecitabine (XELOX) Based Chemotherapy in the Treatment of Metastatic Colorectal Cancer: The Right Choice in Elderly Patients
Anti-Cancer Agents in Medicinal Chemistry HPLC Stability Indicating Assay Method for Metformin Hydrochloride in Bulk Drug and Tablets and Cytotoxicity of Degradation Products
Current Pharmaceutical Analysis Obesity and Gastrointestinal Hormones-Dual Effect of Angiotensin II Receptor Blockade and a Partial Agonist of PPAR-γ
Current Vascular Pharmacology Cachexia and Herbal Medicine: Perspective
Current Pharmaceutical Design Signaling in “Obesity Neurons”
Current Medicinal Chemistry - Immunology, Endocrine & Metabolic Agents Biomedical Consequences of Alcohol Use Disorders in the HIV-Infected Host
Current HIV Research Teaching a Lifestyle Intervention for Reversing Impaired Fasting Glucose, Hyperlipidemia and Obesity/Overweight to a Cohort of Local Physicians
Current Nutrition & Food Science