Issues and Progress in Isolation of Susceptibility Genes of Essential Hypertension

Title: Issues and Progress in Isolation of Susceptibility Genes of Essential Hypertension

Volume: 1 Issue: 1

Author(s): Tomohiro Nakayama

Affiliation:

Keywords: essential hypertension, linkage, association, susceptibility gene, prostacyclin, prostacyclin synthase, natriuretic peptide receptor

Abstract: Essential hypertension (EH) is thought to be a multifactorial disease. In Japan, there are more than 20 million cases of EH, which accounts for 80 to 90% of hypertension cases in Japan. It is very difficult to isolate the susceptibility genes of EH in familial linkage analysis such as sib-pair analysis and association studies such as case-control studies of candidate genes. Whole genome scanning and haplotype analysis using genetic markers will be widely conducted in the future. The present paper contains a review of issues and progress in isolation of susceptibility genes of EH, and an introduction to an effective novel method for isolation of susceptibility genes of EH.

Cite this article as:

Nakayama Tomohiro, Issues and Progress in Isolation of Susceptibility Genes of Essential Hypertension, Current Hypertension Reviews 2005; 1 (1) . https://dx.doi.org/10.2174/1573402052952799