Polyhedral Boron Compounds as Potential Diagnostic and Therapeutic Antitumor Agents

Title: Polyhedral Boron Compounds as Potential Diagnostic and Therapeutic Antitumor Agents

Volume: 6 Issue: 2

Author(s): V. I. Bregadze, I. B. Sivaev and S. A. Glazun

Affiliation:

Keywords: Boron, carborane, borane, boron neutron capture therapy, radionuclides, anticancer drugs

Abstract: The use of polyhedral boron hydrides for cancer treatment is traditionally connected with boron neutron capture therapy. More recently, polyhedral borate anions were proposed as carriers of radionuclide label for targeted radionuclide therapy and diagnostics of cancer. Some metal derivatives of carboranes were found to demonstrate significant antitumor activity themselves. This review is designed to highlight the recent work concerning various fields of potential application of polyhedral boron compounds in anticancer diagnostics and therapy.

Cite this article as:

Bregadze I. V., Sivaev B. I. and Glazun A. S., Polyhedral Boron Compounds as Potential Diagnostic and Therapeutic Antitumor Agents, Anti-Cancer Agents in Medicinal Chemistry 2006; 6 (2) . https://dx.doi.org/10.2174/187152006776119180