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Current Chemical Biology

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ISSN (Print): 2212-7968
ISSN (Online): 1872-3136

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Review Article

Something Old, Something New and Something Used in Alzheimer's; the Idea of Pore, Ethanol and the Use of Oocytes to Understand the Disease

Author(s): Jorge Parodi*

Volume 13, Issue 2, 2019

Page: [105 - 109] Pages: 5

DOI: 10.2174/2212796812666180710125905

Price: $65

Abstract

Background: Alzheimer's disease remains an unsolved public health problem. Recent studies shifted the focus of the pathogenesis from a neurodegenerative process to a synaptic failure, including a large group of pathologies called peptide misfolding diseases.

Objective: In this line, recent research has proposed new models to study the pathologies such as frog oocytes, revalidation of a mechanism such as the amyloid pore, and a link of moderate alcohol consumption with a reduced risk of developing neurodegenerative diseases.

Methods: We reviewed the latest publication in this field.

Conclusion: We believe, therefore, that the available data suggest an important role of the amyloid pore mechanism in the pathogenesis of the Alzheimer's disease, the use of oocytes for its study, and how a moderate consumption of ethanol could reduce the effects of amyloid aggregates.

Keywords: Alzheimer, synapses, calcium, pore, oocytes, peptide misfolding diseases.

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