Abstract
The neglected tropical diseases (NTDs) are caused by several parasites, fungi, bacteria and viruses and affect more than one billion people in the world. The control and prevention against NTDs need implementation of alternative methods for testing new compounds against these diseases. For the implementation of alternative methods, it is necessary to apply the principles of replacement, reduction and refinement (the 3Rs) for the use of laboratory animals. Accordingly, the present review addressed a variety of alternative models to study the infections caused by protozoa and fungi. Overall, vertebrate and invertebrate models of fungal infection have been used to elucidate host-pathogen interactions. However, until now the insect model has not been used in protozoal studies as an alternative method, but there is interest in the scientific community to try new tools to screen alternative drugs to control and prevent protozoal infections.
Keywords: Fungal, leishmaniasis, Chagas disease, alternative methods, alternative host models, target-based approach.
Graphical Abstract
Current Topics in Medicinal Chemistry
Title:Alternative Host Models for Testing Anti-Protozoal or Antifungal Compounds and Fungal Infection
Volume: 18 Issue: 4
Author(s): Ana Claudia Torrecilhas, Patricia Xander, Karen Spadari Ferreira and Wagner Luiz Batista*
Affiliation:
- Laboratorio de Imunologia Celular e Bioquimica de Fungos e Protozoarios, Departamento de Ciencias Farmaceuticas, Universidade Federal de Sao Paulo - Campus Diadema. Rua Sao Nicolau, 210, 4º andar, 04023-900, Diadema,Brazil
Keywords: Fungal, leishmaniasis, Chagas disease, alternative methods, alternative host models, target-based approach.
Abstract: The neglected tropical diseases (NTDs) are caused by several parasites, fungi, bacteria and viruses and affect more than one billion people in the world. The control and prevention against NTDs need implementation of alternative methods for testing new compounds against these diseases. For the implementation of alternative methods, it is necessary to apply the principles of replacement, reduction and refinement (the 3Rs) for the use of laboratory animals. Accordingly, the present review addressed a variety of alternative models to study the infections caused by protozoa and fungi. Overall, vertebrate and invertebrate models of fungal infection have been used to elucidate host-pathogen interactions. However, until now the insect model has not been used in protozoal studies as an alternative method, but there is interest in the scientific community to try new tools to screen alternative drugs to control and prevent protozoal infections.
Export Options
About this article
Cite this article as:
Torrecilhas Claudia Ana, Xander Patricia , Ferreira Spadari Karen and Batista Luiz Wagner *, Alternative Host Models for Testing Anti-Protozoal or Antifungal Compounds and Fungal Infection, Current Topics in Medicinal Chemistry 2018; 18 (4) . https://dx.doi.org/10.2174/1568026618666180412154519
DOI https://dx.doi.org/10.2174/1568026618666180412154519 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |

- Author Guidelines
- Bentham Author Support Services (BASS)
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Effects of Altered Plasminogen Activator Inhibitor-1 Expression on Cardiovascular Disease
Current Drug Targets Cardiovascular Disease in Systemic Lupus Erythematosus: The Role of Traditional and Lupus Related Risk Factors
Current Cardiology Reviews Statistical Optimization and Fabrication of a Press Coated Pulsatile Dosage Form to Treat Nocturnal Acid Breakthrough
Current Drug Delivery ACE2-Ang-(1-7)-Mas Axis in Brain: A Potential Target for Prevention and Treatment of Ischemic Stroke
Current Neuropharmacology Thrombolytic Therapy in Acute Ischemic Stroke - Basic Concepts
Current Vascular Pharmacology Inflammatory Cytokines and Cardiovascular Disease
Current Drug Targets - Inflammation & Allergy Acute Myocardial Infarction in Systemic Mastocytosis: Case Report With Literature Review on the Role of Inflammatory Process in Acute Coronary Syndrome
Current Cardiology Reviews Mechanisms of Inflammatory Atherosclerosis in Rheumatoid Arthritis
Current Immunology Reviews (Discontinued) Pharmacotherapy and HDL Cholesterol
Current Medicinal Chemistry - Immunology, Endocrine & Metabolic Agents Sonographic Diagnosis of Fetal Intraventricular Hemorrhage: Report of Three Cases and Review of the Literature
Recent Patents on Medical Imaging Platelet Turnover in Atherothrombotic Disease
Current Pharmaceutical Design Role of Biotransformation in Conceptal Toxicity of Drugs and Other Chemicals
Current Pharmaceutical Design A Glance at Taenia Saginata Infection, Diagnosis, Vaccine, Biological Control and Treatment
Infectious Disorders - Drug Targets Impact of Macrophages in Atherosclerosis
Current Medicinal Chemistry Unusual Food Allergy: AlioideaAllergic Reactions Overview
Recent Patents on Inflammation & Allergy Drug Discovery Mitochondrial Dysfunction and Targeted Drugs: A Focus on Diabetes
Current Pharmaceutical Design Diabetes Mellitus and SARS-CoV-2 Infection: Pathophysiologic Mechanisms and Implications in Management
Current Diabetes Reviews Modulation of Mitochondrial Permeability Transition in Ischemia-Reperfusion Injury of the Heart. Advantages and Limitations
Current Medicinal Chemistry Platelets in the Alzheimer’s Disease Brain: do they Play a Role in Cerebral Amyloid Angiopathy?
Current Neurovascular Research Percutaneous Valve Interventions
Current Cardiology Reviews