Natural Terpenoids Against Female Breast Cancer: A 5-year Recent Research

Title:Natural Terpenoids Against Female Breast Cancer: A 5-year Recent Research

Volume: 25 Issue: 27

Author(s): Sylvin Benjamin Ateba*, Marie Alfrede Mvondo, Sadrine Tchoukouegno Ngeu, Job Tchoumtchoua, Charline Florence Awounfack, Dieudonne Njamen and Liselotte Krenn

Affiliation:

• Laboratory of Animal Physiology, Department of Animal Biology and Physiology, Faculty of Science, University of Yaounde I, P.O. Box 812 Yaounde,Cameroon

Keywords: Breast, anti-cancer, terpenoids/terpenes, carcinogenesis, breast cancer, breast cancer treatment.

Abstract: Background: The approval of Taxol® in 1993 marked the great entrance of terpenoids in the anti-cancer area and this drug is still highly important in the treatment of refractory ovarian, breast and other cancers. Over decades, other prominent natural terpenoids have become indispensable for the modern pharmacotherapy of breast cancer. However, given the rapid evolution of drug resistance, effective treatments for advanced breast cancers requiring cytotoxic chemotherapy represent a major unmet clinical need. Therefore, innovative agents effective in long-term chemotherapy are urgently needed.

Objective: This review examines recent advances/research about natural terpenoids, and their mechanisms against female breast cancer over the period covering January 1st, 2012 to December 31st, 2016.

Results: Carcinogenesis constitutes a multistep process wherein each stage is characterized by distinct phenotypic changes. Numerous chemicals recorded in this review have been shown to significantly inhibit proliferation, migration, apoptosis resistance, tumor angiogenesis or metastasis in different breast cancer cells/tumours in vitro and in vivo. Targeting simultaneously several or all these aspects/steps of cancer progression could be an advantage. In line with this, phytochemicals such as thymoquinone (8), costunolide (46), tanshinone IIA (132), triptolide (136), cucurbitacin B (179), celastrol (226) and lycopene (238) had caught our attention.

Conclusion: These compounds appear to be promising to overcome breast cancer treatment failure. However, despite the interesting activities, additional preclinical investigations are needed in further breast cancer cell/tumor models in vitro and in vivo.

Cite this article as:

Ateba Benjamin Sylvin*, Mvondo Alfrede Marie , Ngeu Tchoukouegno Sadrine, Tchoumtchoua Job , Awounfack Florence Charline , Njamen Dieudonne and Krenn Liselotte , Natural Terpenoids Against Female Breast Cancer: A 5-year Recent Research, Current Medicinal Chemistry 2018; 25 (27) . https://dx.doi.org/10.2174/0929867325666180214110932