Regulation Mechanism of MicroRNAs in Non-Small Cell Lung Cancer

Title:Regulation Mechanism of MicroRNAs in Non-Small Cell Lung Cancer

Volume: 23 Issue: 39

Author(s): Feng-Yun Gong, Tao Bai, Ding-Yu Zhang*, Chao-lin Huang, Jing Lv, Jing-Li Wang, Xu-Dong Hu, Juan Wang and Wei Liu

Affiliation:

• Departments of Infectious Diseases Wuhan Medical Treatment Center, Wuhan 430023,China

Keywords: Regulation mechanism, MicroRNAs, non-coding RNAs, non-small cell lung cancer (NSCLC), tumor, oncogenes.

Abstract: MicroRNAs are small non-coding RNAs with regulatory biological activity, by modulating target genes on epigenetic, transcriptional, post-transciptional and translational levels. Hundreds of reports indicated that miRNAs play important roles in non-small cell lung cancer (NSCLC). Actually, microRNAs are both regulation targets and regulators targeting effector genes. This article reviewed multifaceted role of microRNAs associated to NSCLC, not only targeting to but also targeted by tumor related genes, to help us understand microRNAs related complex regulation networks. Aberrant expressed micoRNAs and their targets were summarized; the statistical results showed that several microRNAs may play key roles by targeting multiple tumor associated targets. On the other hand, Oncogenes and tumor repressors represented by PTEN were also shown to be the most popular targets of microRNAs. Additionally, ZEB1/2 may be a featured pathway in NSCLC, with significant frequency modulated by microRNAs.

Cite this article as:

Gong Feng-Yun , Bai Tao , Zhang Ding-Yu *, Huang Chao-lin , Lv Jing , Wang Jing-Li , Hu Xu-Dong , Wang Juan and Liu Wei , Regulation Mechanism of MicroRNAs in Non-Small Cell Lung Cancer, Current Pharmaceutical Design 2017; 23 (39) . https://dx.doi.org/10.2174/1381612823666170714153424