Abstract
Alcohol addiction or alcoholism is the most severe form of problem drinking. A variety of treatment methods for alcoholism are currently available that combine medications, behavioral treatment and peer support. The drugs that are currently approved by the U.S. Food and Drug Administration (FDA) for treatment of alcohol dependence are disulfiram, naltrexone and acamprosate. For many patients, however, these treatments are not effective. Evidence from a number of studies suggests that various factors, both psychosocial and economic, as well as genetic variation, are significant contributors to interindividual variation both of clinical presentation of alcohol problems and response to a given treatment. The aim of the present review is to summarize and discuss different aspects of personalized medicine of alcohol addiction. We focus on pharmacogenomics and beyond, to include the genetics and epigenetics of alcohol addiction as well as other psychosocial and even economic factors that may affect response to alcohol addiction pharmacotherapy. It is anticipated that, within the next 5-10 years, personalized medicine of alcohol addiction will be a reality and it will help reduce the burden of alcoholism from society and increase the well-being and productivity of individuals addicted to alcohol.
Keywords: Alcohol, addiction, disulfiram, naltrexone, acamprosate, pharmacogenetics, personalized drug treatment.
Current Pharmaceutical Biotechnology
Title:Personalized Medicine of Alcohol Addiction: Pharmacogenomics and Beyond
Volume: 18 Issue: 3
Author(s): Georgia Ragia and Vangelis G. Manolopoulos*
Affiliation:
- Laboratory of Pharmacology, Medical School, Democritus University of Thrace, Dragana Campus, 68100 Alexandroupolis,Greece
Keywords: Alcohol, addiction, disulfiram, naltrexone, acamprosate, pharmacogenetics, personalized drug treatment.
Abstract: Alcohol addiction or alcoholism is the most severe form of problem drinking. A variety of treatment methods for alcoholism are currently available that combine medications, behavioral treatment and peer support. The drugs that are currently approved by the U.S. Food and Drug Administration (FDA) for treatment of alcohol dependence are disulfiram, naltrexone and acamprosate. For many patients, however, these treatments are not effective. Evidence from a number of studies suggests that various factors, both psychosocial and economic, as well as genetic variation, are significant contributors to interindividual variation both of clinical presentation of alcohol problems and response to a given treatment. The aim of the present review is to summarize and discuss different aspects of personalized medicine of alcohol addiction. We focus on pharmacogenomics and beyond, to include the genetics and epigenetics of alcohol addiction as well as other psychosocial and even economic factors that may affect response to alcohol addiction pharmacotherapy. It is anticipated that, within the next 5-10 years, personalized medicine of alcohol addiction will be a reality and it will help reduce the burden of alcoholism from society and increase the well-being and productivity of individuals addicted to alcohol.
Export Options
About this article
Cite this article as:
Ragia Georgia and Manolopoulos G. Vangelis*, Personalized Medicine of Alcohol Addiction: Pharmacogenomics and Beyond, Current Pharmaceutical Biotechnology 2017; 18 (3) . https://dx.doi.org/10.2174/1389201018666170224105025
DOI https://dx.doi.org/10.2174/1389201018666170224105025 |
Print ISSN 1389-2010 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4316 |

- Author Guidelines
- Bentham Author Support Services (BASS)
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Creating Chemical Diversity to Target Protein Kinases
Combinatorial Chemistry & High Throughput Screening Role of Antioxidants in Redox Regulation of Diabetic Cardiovascular Complications
Current Pharmaceutical Biotechnology Challenging Treatment-Resistant Major Depressive Disorder: A Roadmap for Improved Therapeutics
Current Neuropharmacology Small Heat Shock Proteins (sHSPs) As Potential Drug Targets
Current Pharmaceutical Biotechnology The Anti-Inflammatory Role of Minocycline in Alzheimer´s Disease
Current Alzheimer Research Cyclization in Opioid Peptides
Current Drug Targets Impacts of Pseudo Amino Acid Components and 5-steps Rule to Proteomics and Proteome Analysis
Current Topics in Medicinal Chemistry The Contribution of γδ T Cells to the Pathogenesis of EAE and MS
Current Molecular Medicine The Potential of Nano-Vehicle Mediated Therapy in Vasculitis and Multiple Sclerosis
Current Pharmaceutical Design The Importance of Complying with Vaccination Protocols in Developed Countries: “Anti-Vax” Hysteria and the Spread of Severe Preventable Diseases
Current Medicinal Chemistry Lack of Association between Genetic Polymorphism of Circadian Genes (PER2, PER3, CLOCK and OX2R) with Late Onset Depression and Alzheimer's Disease in a Sample of a Brazilian Population (Circadian Genes, Late-Onset Depression and Alzheimer's Disease)
Current Alzheimer Research Drug-Metabolizing Enzymes Mechanisms and Functions
Current Drug Metabolism Regulation of Neurotrophic Factors and Energy Metabolism by Antidepressants in Astrocytes
Current Drug Targets Regulation of Mitochondrial Biogenesis in Metabolic Syndrome
Current Drug Targets Recent Patents on the Optical Resolution of Amino Acid Enantiomers by Crystallization from Solution
Recent Patents on Materials Science Production, Purification and Characterization of Adeno-Associated Vectors
Current Gene Therapy Breast Cancer Risks in Premenopausal Women: A Review
Current Women`s Health Reviews Molecular and Genetic Mechanisms of Osteoporosis: Implication for Treatment
Current Molecular Medicine Management of Connective Tissue Interstitial Lung Disease
Current Respiratory Medicine Reviews The Anticholinesterase Activity of Three Local Food Spices and Their Anti-Alzheimer Application
Current Nutraceuticals