Near-infrared Light Responsive Polymeric Nanocomposites for Cancer Therapy

Title:Near-infrared Light Responsive Polymeric Nanocomposites for Cancer Therapy

Volume: 17 Issue: 16

Author(s): Cong Min, Xueqing Zou, Quanzhu Yang, Liqiong Liao*, Guofu Zhou*Lijian Liu

Affiliation:

• College of Chemistry and Molecular Science, Wuhan University, Wuhan, Hubei 430072,China

• Institute of Electronic Paper Display, South China Academy of Advanced Optoelectronics, South China Normal University, Guangzhou 510006,China

Keywords: Near infrared, Photothermal therapy, Chemotherapy, Polymeric nanocomposites.

Abstract: Inorganic nanoparticles, which can absorb and convert near infrared (NIR) light to heat to ablate cancer cells, have been widely investigated in photothermal therapy. However, the inherent poor solubility and acute systemic toxicity of these inorganic particles hinder their application in clinical practice. Polymeric nanocomposites materials containing both inorganic nanoparticles and polymers could be harnessed to achieve enhanced photothermal therapeutic effect as well as improved biocompatibility and multi-responsiveness. Synergistic chemo-photothermal efficacy towards cancer cells and tumor tissue can thus be realized through such multi-functional and multi-responsive polymeric nanocomposites. In this review, the recent developments in polymeric nanocomposites based on different types of inorganic nanoparticles (i.e. gold, carbon nanotube, graphene, and upconversion nanoparticles) for NIR-triggered cancer therapy are summarized.

Cite this article as:

Min Cong, Zou Xueqing, Yang Quanzhu, Liao Liqiong*, Zhou Guofu*, Liu Lijian, Near-infrared Light Responsive Polymeric Nanocomposites for Cancer Therapy, Current Topics in Medicinal Chemistry 2017; 17 (16) . https://dx.doi.org/10.2174/1568026617666161122120153