Development of Antibacterial Drugs by Targeting Toll-Like Receptors

Title:Development of Antibacterial Drugs by Targeting Toll-Like Receptors

Volume: 17 Issue: 3

Author(s): Qun Xu, Gengzheng Zhu, Jing Li and Kui Cheng

Affiliation:

Keywords: Antimicrobial, Toll-like receptor, Inflammation, Natural product, Peptide, Synthetic molecule.

Abstract: The invading microbial pathogens are controlled by the rapid and effective innate immune responses sequentially formation of the long-lasting adaptive memories. Toll-like receptors (TLRs) play a vital role in innate and adaptive immune response by function as a bridge to modulate the immune response. Further, genetic studies in human or animals showed that regulation of TLR signaling contributes to the antibacterial efficacy, and developing novel reagent to modulate TLR related immune response becomes an interesting therapy method to against bacterial infections. Herein we review the recent developments of this area, focusing on the reagent of synthetic molecules, natural products and peptides (or proteins), as TLR-related antibacterial drugs.

Cite this article as:

Xu Qun, Zhu Gengzheng, Li Jing and Cheng Kui, Development of Antibacterial Drugs by Targeting Toll-Like Receptors, Current Topics in Medicinal Chemistry 2017; 17 (3) . https://dx.doi.org/10.2174/1568026616666160829161639