Abstract
Organic and inorganic nanoparticles show great potential for cancer diagnosis and treatment. Because gastric cancer (GC) represents the second most deadly type of neoplasia worldwide, continued research efforts by scientists and clinicians are essential to improve diagnosis and treatment. This paper reviews significant findings in the area of nanoparticles (organic and inorganic origin) that may aid in prevention and diagnosis of GC. This review focuses in the first section on H. pylori and the connection to GC, highlighting nanoformulations designed to control bacterial growth. The second section evaluates the potential of different imaging techniques (especially using inorganic nanoparticles) in the detection of GC, and the third section summarizes how nanotechnology may be employed in the analytical detection of GC biomarkers (metallic plasmons, electrochemical biosensors and colorimetric sensors). We foresee that the prevention and diagnosis of GC will require the development of complex collaborative studies. Additionally, scientists also need to be tightly connected to industry in order to facilitate upscaling and rapid transfer of promising products to the clinic.
Keywords: Nanocarriers, biomarkers, drug delivery, Helicobacter pylori, gastric cancer, epigenetic.
Current Pharmaceutical Design
Title:Organic and Inorganic Nanoparticles for Prevention and Diagnosis of Gastric Cancer
Volume: 21 Issue: 29
Author(s): Felipe Oyarzun-Ampuero, Ariel Guerrero, Natalia Hassan-Lopez, Javier O. Morales, Soledad Bollo, Alejandro Corvalan, Andrew F.G. Quest and Marcelo J. Kogan
Affiliation:
Keywords: Nanocarriers, biomarkers, drug delivery, Helicobacter pylori, gastric cancer, epigenetic.
Abstract: Organic and inorganic nanoparticles show great potential for cancer diagnosis and treatment. Because gastric cancer (GC) represents the second most deadly type of neoplasia worldwide, continued research efforts by scientists and clinicians are essential to improve diagnosis and treatment. This paper reviews significant findings in the area of nanoparticles (organic and inorganic origin) that may aid in prevention and diagnosis of GC. This review focuses in the first section on H. pylori and the connection to GC, highlighting nanoformulations designed to control bacterial growth. The second section evaluates the potential of different imaging techniques (especially using inorganic nanoparticles) in the detection of GC, and the third section summarizes how nanotechnology may be employed in the analytical detection of GC biomarkers (metallic plasmons, electrochemical biosensors and colorimetric sensors). We foresee that the prevention and diagnosis of GC will require the development of complex collaborative studies. Additionally, scientists also need to be tightly connected to industry in order to facilitate upscaling and rapid transfer of promising products to the clinic.
Export Options
About this article
Cite this article as:
Oyarzun-Ampuero Felipe, Guerrero Ariel, Hassan-Lopez Natalia, Morales O. Javier, Bollo Soledad, Corvalan Alejandro, Quest F.G. Andrew and Kogan J. Marcelo, Organic and Inorganic Nanoparticles for Prevention and Diagnosis of Gastric Cancer, Current Pharmaceutical Design 2015; 21 (29) . https://dx.doi.org/10.2174/1381612821666150901095538
DOI https://dx.doi.org/10.2174/1381612821666150901095538 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Phytochemical and Pharmacological Insight on Sesamol: An Updated Review
Current Bioactive Compounds A Systematic Analysis of Physicochemical and ADME Properties of All Small Molecule Kinase Inhibitors Approved by US FDA from January 2001 to October 2015
Current Medicinal Chemistry Modulation of Expression and Activity of ABC Transporters by the Phytoestrogen Genistein. Impact on Drug Disposition
Current Medicinal Chemistry Preface:
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Growth Hormone Secretagogue (Ghrelin-) Receptors - A Complex Drug Target for the Regulation of Body Weight
CNS & Neurological Disorders - Drug Targets Immunonutrition in Surgical Patients
Current Drug Targets Biomarker Discovery and Translation in Metabolomics
Current Metabolomics Use of Anti-Cancer Drugs, Mitocans, to Enhance the Immune Responses against Tumors
Current Pharmaceutical Biotechnology Melatonin: Pharmacology, Functions and Therapeutic Benefits
Current Neuropharmacology Activation of Macrophages: Establishing a Role for Polysaccharides in Drug Delivery Strategies Envisaging Antibacterial Therapy
Current Pharmaceutical Design Microwave-promoted One-pot Synthesis of Imidazo[1,2-a]pyridines in Lemon Juice
Current Microwave Chemistry Radioiodinated Agents for Imaging Multidrug Resistant Tumors
Medicinal Chemistry Aberrant Activation of Arachidonic Acid and Eicosanoid Pathways-Targets for Treating Prostate Cancer
Recent Patents on Endocrine, Metabolic & Immune Drug Discovery (Discontinued) Determination of Protodioscin in Rabbit Plasma by LC-MS/MS Method: Application to Preclinical Pharmacokinetics
Current Pharmaceutical Analysis Green Tea Polyphenols as Proteasome Inhibitors: Implication in Chemoprevention
Current Cancer Drug Targets Brain Tumor-Related Epilepsy
Current Neuropharmacology HIF-1 Signaling in Drug Resistance to Chemotherapy
Current Medicinal Chemistry Emerging Indications for Statins: A Pluripotent Family of Agents with Several Potential Applications
Current Pharmaceutical Design PDGF-D Signaling: A Novel Target in Cancer Therapy
Current Drug Targets DNA Microarrays: Perspectives for Hypothesis-Driven Transcriptome Research and for Clinical Applications
Current Genomics