Dual Inhibition and Monitoring of Beta-Amyloid Fibrillation by a Luminescent Iridium(III) Complex

Chun-Yuen      Wong; Lai-Hon      Chung; Lihua      Lu; Modi      Wang; Bingyong      He; Li-Juan      Liu; Chung-Hang      Leung; Dik-Lung      Ma

doi:10.2174/1567205012666150504144558

Abstract

In this study, we report the synthesis and application of the novel cyclometallated luminescent Ir(III) complex 1 bearing the C^C^C ligand as a probe and inhibitor of Aβ fibrillation. We envisage that this kinetically-inert Ir(III) complex may be potentially developed as a dual-purpose probe and inhibitor of Aβ aggregation for Alzheimer’s disease diagnosis and treatment.

Keywords: Amyloid, aggregation, Alzheimer's, luminescent probe, iridium.

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DOI https://dx.doi.org/10.2174/1567205012666150504144558	Print ISSN 1567-2050
Publisher Name Bentham Science Publisher	Online ISSN 1875-5828

Current Alzheimer Research

Dual Inhibition and Monitoring of Beta-Amyloid Fibrillation by a Luminescent Iridium(III) Complex

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