Abstract
Aerosolized therapies have been used in everyday clinical practice for decades. Experimentation with different delivery systems have led to the creation of aerosolized insulin, antibiotics, gene therapy and chemotherapy. Several of these therapies are already clinically available while others are being investigated in active clinical trials. The main factors affecting the efficiency and safety of the aerosolized therapies are the production of the aerosol, distribution/deposition of the aerosol throughout the lung parenchyma, respiratory defense mechanisms and tissue/pharmaceutical molecule interactions. Current methods of aerosol production and distribution will be presented along with an overview of the respiratory defense mechanisms. In addition, methods of aerosol evaluation in conjunction with a future perspective of the potential development of aerosol therapies will be presented.
Keywords: Respiratory system, defense mechanisms, aerosol, dry powder, inhalers.
Medicinal Chemistry
Title:Defense Mechanisms of the Respiratory System and Aerosol Production Systems
Volume: 10 Issue: 2
Author(s): Paul Zarogoulidis, Kaid Darwiche, Lonny Yarmus, Dionysios Spyratos, Nevena Secen, Wolfgang Hohenforst-Schmidt, Nikolaos Katsikogiannis, Haidong Huang, Andreas Gschwendtner and Konstantinos Zarogoulidis
Affiliation:
Keywords: Respiratory system, defense mechanisms, aerosol, dry powder, inhalers.
Abstract: Aerosolized therapies have been used in everyday clinical practice for decades. Experimentation with different delivery systems have led to the creation of aerosolized insulin, antibiotics, gene therapy and chemotherapy. Several of these therapies are already clinically available while others are being investigated in active clinical trials. The main factors affecting the efficiency and safety of the aerosolized therapies are the production of the aerosol, distribution/deposition of the aerosol throughout the lung parenchyma, respiratory defense mechanisms and tissue/pharmaceutical molecule interactions. Current methods of aerosol production and distribution will be presented along with an overview of the respiratory defense mechanisms. In addition, methods of aerosol evaluation in conjunction with a future perspective of the potential development of aerosol therapies will be presented.
Export Options
About this article
Cite this article as:
Zarogoulidis Paul, Darwiche Kaid, Yarmus Lonny, Spyratos Dionysios, Secen Nevena, Hohenforst-Schmidt Wolfgang, Katsikogiannis Nikolaos, Huang Haidong, Gschwendtner Andreas and Zarogoulidis Konstantinos, Defense Mechanisms of the Respiratory System and Aerosol Production Systems, Medicinal Chemistry 2014; 10 (2) . https://dx.doi.org/10.2174/157340641130900041
DOI https://dx.doi.org/10.2174/157340641130900041 |
Print ISSN 1573-4064 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6638 |

- Author Guidelines
- Bentham Author Support Services (BASS)
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
NADPH Oxidases in the Heart
Current Cardiology Reviews Targeting the Secretory Pathway for Anti-Inflammatory Drug Development
Current Topics in Medicinal Chemistry IL-22 Produced by T helper Cell 22 as a New player in the Pathogenesis of Immune Thrombocytopenia
Endocrine, Metabolic & Immune Disorders - Drug Targets Recent Progress in Chemically Modified siRNAs
Mini-Reviews in Medicinal Chemistry Amyloid-β Peptides, Alzheimer's Disease and the Blood-brain Barrier
Current Alzheimer Research Inflammation and Inflammatory Cell Recruitment in Acute Cerebrovascular Diseases
Current Immunology Reviews (Discontinued) An Overview on Inventions Related to Ginger Processing and Products for food and Pharmaceutical Applications
Recent Patents on Food, Nutrition & Agriculture Immunomodulatory Properties of ES-62, a Phosphorylcholine - Containing Glycoprotein Secreted by Acanthocheilonema viteae
Endocrine, Metabolic & Immune Disorders - Drug Targets Perceptions in Type 1 Diabetes Mellitus with or Without the Use of Insulin Pump: An Online Study
Current Diabetes Reviews A Systematic Review on Anti-diabetic Properties of Chalcones
Current Medicinal Chemistry The Important New Drug Target in Cardiovascular Medicine – the Vascular Glycocalyx
Cardiovascular & Hematological Disorders-Drug Targets Meet Our Editorial Board Member
Current Medicinal Chemistry Design, Synthesis and Evaluation of Peroxisome Proliferator-Activated Receptor α/βDual Agonists for the Treatment of Type 2 Diabetes
Letters in Drug Design & Discovery IGF Signaling Pathway as a Selective Target of Familial Breast Cancer Therapy
Current Molecular Medicine Clinical, Molecular, and Genetic Characteristics of PAPA Syndrome: A Review
Current Genomics Environmental Pollution and Diabetes Mellitus
Recent Patents on Biomarkers Profile of IKs During the Action Potential Questions the Therapeutic Value of IKs Blockade
Current Medicinal Chemistry A form of Autoimmune Diabetes in Adults Named LADA – An Update on Essential Features and Controversies
Current Diabetes Reviews Analysis of Contrast-Enhanced Intravascular Ultrasound Images for the Assessment of Coronary Plaque Neoangiogenesis: Another Step Closer to the Identification of the Vulnerable Plaque
Current Pharmaceutical Design Affective Disorder and Hyperandrogenism
Recent Patents on Endocrine, Metabolic & Immune Drug Discovery (Discontinued)