Abstract
Sirtuins form a large homology family of enzymes found almost ubiquitously in living organisms and involved in numerous biological processes. The human genome encodes for seven paralog sirtuins, identified as SIRT1 – 7. In this review the major structural features of the sirtuin catalytic domain are illustrated and the relevant sources of biological information indicated. The multiple sequence alignment deduced from the optimal structural superposition of four human sirtuins having known three-dimensional structure, to which the amino acid sequences of the remaining three have been subsequently aligned, is also analyzed. The structure of the neighbor-joining tree deduced from the multiple sequence alignment, summarizing the evolutionary relationship among the member of the homology family is illustrated also in relation with the distinct catalytic activities detected in members this homology family.
Keywords: Sirtuins, evolution, rossman fold, deacetylase.
Current Drug Targets
Title:Structure and Evolution of Human Sirtuins
Volume: 14 Issue: 6
Author(s): Domenico Bordo
Affiliation:
Keywords: Sirtuins, evolution, rossman fold, deacetylase.
Abstract: Sirtuins form a large homology family of enzymes found almost ubiquitously in living organisms and involved in numerous biological processes. The human genome encodes for seven paralog sirtuins, identified as SIRT1 – 7. In this review the major structural features of the sirtuin catalytic domain are illustrated and the relevant sources of biological information indicated. The multiple sequence alignment deduced from the optimal structural superposition of four human sirtuins having known three-dimensional structure, to which the amino acid sequences of the remaining three have been subsequently aligned, is also analyzed. The structure of the neighbor-joining tree deduced from the multiple sequence alignment, summarizing the evolutionary relationship among the member of the homology family is illustrated also in relation with the distinct catalytic activities detected in members this homology family.
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Cite this article as:
Bordo Domenico, Structure and Evolution of Human Sirtuins, Current Drug Targets 2013; 14 (6) . https://dx.doi.org/10.2174/1389450111314060007
DOI https://dx.doi.org/10.2174/1389450111314060007 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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