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Solubility, Delivery and ADME Problems of Drugs and Drug-Candidates

Author(s) : Karoly Tihanyi, Monika Vastag

DOI: 10.2174/97816080512051110101
eISBN: 978-1-60805-120-5, 2011
ISBN: 978-1-60805-619-4

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Request history8.2.27PHP Version242msRequest Duration27MBMemory UsageGET ebook_volume/{id}/{page_name?}/{param?}Route
    • Booting (130ms)time
    • Application (112ms)time
    • 1 x Booting (53.76%)
      130ms
      1 x Application (46.23%)
      112ms
      10 templates were rendered
      • ebook.ebook_volume_relatedebook_volume_related.blade.php#?blade
      • layouts.ebook_volume_header_sectionebook_volume_header_section.blade.php#?blade
      • ...related_journalsrelated_journals.blade.php#?blade
      • pagination::bootstrap-4bootstrap-4.blade.php#?blade
      • ebook.ebook_right_bannerebook_right_banner.blade.php#?blade
      • layouts.appapp.blade.php#?blade
      • layouts._login_access_login_access.blade.php#?blade
      • layouts._header_header.blade.php#?blade
      • layouts._main_menu_main_menu.blade.php#?blade
      • layouts._footer_menu_footer_menu.blade.php#?blade
      uri
      GET ebook_volume/{id}/{page_name?}/{param?}
      middleware
      web, check_user_access
      controller
      App\Http\Controllers\EbookVolumeController@GetEbookVolumeDetails
      namespace
      App\Http\Controllers
      where
      as
      ebook_volume
      file
      app/Http/Controllers/EbookVolumeController.php:1486-1958
      18 statements were executed, 2 of which were duplicates, 16 unique. Show only duplicated34.36ms
      • Connection Establishedalphaeurekaselec_live_10_06_2022UserAccessCheck.php#24
        Backtrace
        • 9. middleware::check_user_access:24
        • 10. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
        • 11. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
        • 12. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
        • 13. vendor/laravel/framework/src/Illuminate/Foundation/Http/Middleware/VerifyCsrfToken.php:88
      • INSERT INTO visitor_ip_address (ip_address,visitor_agent,visitor_count, created_on,updated_on) VALUES ('316269629','',1,1740676946,1740676946) ON DUPLICATE KEY UPDATE visitor_count=visitor_count + 1, updated_on=1740676946
        1.21msalphaeurekaselec_live_10_06_2022UserAccessCheck.php#24
        Backtrace
        • 11. middleware::check_user_access:24
        • 12. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
        • 13. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
        • 14. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
        • 15. vendor/laravel/framework/src/Illuminate/Foundation/Http/Middleware/VerifyCsrfToken.php:88
      • INSERT INTO visitor_ip_address_detail (ip_address,visitor_url,visitor_count, created_on,updated_on) VALUES ('316269629','/ebook_volume/983/related-journals?page=3',1,1740676946,1740676946)
        230μsalphaeurekaselec_live_10_06_2022UserAccessCheck.php#27
        Backtrace
        • 11. middleware::check_user_access:27
        • 12. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
        • 13. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
        • 14. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
        • 15. vendor/laravel/framework/src/Illuminate/Foundation/Http/Middleware/VerifyCsrfToken.php:88
      • (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_journal_volume_trail WHERE to_ip >= 316269629 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316269629) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_journal_volume_corporate WHERE to_ip >= 316269629 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316269629) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_journal_volume_token WHERE to_ip >= 316269629 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316269629) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_ebook_volume_trail WHERE to_ip >= 316269629 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316269629) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_ebook_volume_corporate WHERE to_ip >= 316269629 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316269629) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_ebook_volume_token WHERE to_ip >= 316269629 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316269629) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_issue_trail WHERE to_ip >= 316269629 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316269629) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_issue_corporate WHERE to_ip >= 316269629 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316269629) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_issue_token WHERE to_ip >= 316269629 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316269629) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_article_trail WHERE to_ip >= 316269629 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316269629) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_article_corporate WHERE to_ip >= 316269629 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316269629) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_article_token WHERE to_ip >= 316269629 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316269629) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_chapter_trail WHERE to_ip >= 316269629 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316269629) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_chapter_corporate WHERE to_ip >= 316269629 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316269629) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_chapter_token WHERE to_ip >= 316269629 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316269629) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_disease_corporate WHERE to_ip >= 316269629 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 316269629) limit 1
        21.01msalphaeurekaselec_live_10_06_2022UserAccess.php#784
        Bindings
        • 0: 316269629
        • 1: 316269629
        • 2: 316269629
        • 3: 316269629
        • 4: 316269629
        • 5: 316269629
        • 6: 316269629
        • 7: 316269629
        • 8: 316269629
        • 9: 316269629
        • 10: 316269629
        • 11: 316269629
        • 12: 316269629
        • 13: 316269629
        • 14: 316269629
        • 15: 316269629
        Backtrace
        • 14. app/Models/UserAccess/UserAccess.php:784
        • 15. middleware::check_user_access:114
        • 16. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
        • 17. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
        • 18. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • select `year`, `id` from `year` order by `year` asc
        260μsalphaeurekaselec_live_10_06_2022Journal.php#197
        Backtrace
        • 13. app/Models/Journal.php:197
        • 14. app/Http/Controllers/EbookVolumeController.php:1555
        • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
        • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
        • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • select `e`.*, `a`.*, `y`.`year`, `e`.`ebook_volume_id` as `ebook_volume_id`, `a`.`ebook_volume_id` as `ebk_vol_id`, `e`.`ebook_id` as `ebk_ebook_id` from `ebook_volume` as `e` left join `author` as `a` on `e`.`ebook_volume_id` = `a`.`ebook_volume_id` left join `year` as `y` on `y`.`id` = `e`.`year_id` where `e`.`ebook_volume_id` = '983' and `e`.`is_uploaded` = 1
        570μsalphaeurekaselec_live_10_06_2022EbookVolume.php#271
        Bindings
        • 0: 983
        • 1: 1
        Backtrace
        • 13. app/Models/EbookVolume.php:271
        • 14. app/Http/Controllers/EbookVolumeController.php:1556
        • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
        • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
        • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • select `ie`.`index_id`, `ie`.`ebook_volume_id`, `i`.`title` from `indexing_ebook` as `ie` left join `indexing_agencies` as `i` on `ie`.`index_id` = `i`.`index_id` where `ie`.`ebook_volume_id` = '983' and `i`.`status` = 1 order by `i`.`title` asc
        290μsalphaeurekaselec_live_10_06_2022Indexing.php#345
        Bindings
        • 0: 983
        • 1: 1
        Backtrace
        • 13. app/Models/Indexing.php:345
        • 14. app/Http/Controllers/EbookVolumeController.php:1557
        • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
        • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
        • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • select count(*) as aggregate from (select `chapter`.*, group_concat(a.first_name,' ',a.last_name) as author_name from `chapter` left join `author` as `a` on `a`.`chapter_id` = `chapter`.`chapter_id` where `chapter`.`ebook_volume_id` = '983' and `chapter`.`is_uploaded` = 1 group by `chapter`.`chapter_id`) as `aggregate_table`
        830μsalphaeurekaselec_live_10_06_2022Chapter.php#97
        Bindings
        • 0: 983
        • 1: 1
        Backtrace
        • 16. app/Models/Chapter.php:97
        • 17. app/Http/Controllers/EbookVolumeController.php:1568
        • 18. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
        • 19. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
        • 20. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • select `chapter`.*, group_concat(a.first_name,' ',a.last_name) as author_name from `chapter` left join `author` as `a` on `a`.`chapter_id` = `chapter`.`chapter_id` where `chapter`.`ebook_volume_id` = '983' and `chapter`.`is_uploaded` = 1 group by `chapter`.`chapter_id` order by `chapter`.`chapter_no` asc limit 100 offset 200
        730μsalphaeurekaselec_live_10_06_2022Chapter.php#97
        Bindings
        • 0: 983
        • 1: 1
        Backtrace
        • 14. app/Models/Chapter.php:97
        • 15. app/Http/Controllers/EbookVolumeController.php:1568
        • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
        • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
        • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • select * from `ebook` where `ebook_id` = 185 limit 1
        310μsalphaeurekaselec_live_10_06_2022EbookVolumeController.php#1570
        Bindings
        • 0: 185
        Backtrace
        • 16. app/Http/Controllers/EbookVolumeController.php:1570
        • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
        • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
        • 19. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
        • 20. vendor/laravel/framework/src/Illuminate/Routing/Route.php:206
      • select count(*) rcd from `ebook_volume` where `ebook_id` = 185 and ebook_volume_id <> 983 limit 1
        400μsalphaeurekaselec_live_10_06_2022EbookVolume.php#999
        Bindings
        • 0: 185
        Backtrace
        • 14. app/Models/EbookVolume.php:999
        • 15. app/Http/Controllers/EbookVolumeController.php:1571
        • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
        • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
        • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • select count(*) as aggregate from `subject_ebook` as `se` inner join `ebook` as `e` on `e`.`ebook_id` = `se`.`ebook_id` inner join `ebook_volume` as `v` on `v`.`ebook_id` = `e`.`ebook_id` where subject_id IN (select subject_id FROM subject_ebook WHERE ebook_id=185) and se.ebook_id!=185 and v.ebook_status='1'
        2.23msalphaeurekaselec_live_10_06_2022Subject.php#238
        Backtrace
        • 16. app/Models/Subject.php:238
        • 17. app/Http/Controllers/EbookVolumeController.php:1574
        • 18. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
        • 19. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
        • 20. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • select distinct v.nid as volume_id,e.nid,e.title,v.issn,v.eissn,v.isbn,v.eisbn,e.ebook_id, v.image_file_name,v.file_path,v.flyer_link,v.ebook_volume_id, v.volume_name,v.doi,v.year_id,v.introduction from `subject_ebook` as `se` inner join `ebook` as `e` on `e`.`ebook_id` = `se`.`ebook_id` inner join `ebook_volume` as `v` on `v`.`ebook_id` = `e`.`ebook_id` where subject_id IN (select subject_id FROM subject_ebook WHERE ebook_id=185) and se.ebook_id!=185 and v.ebook_status='1' limit 10 offset 20
        1.55msalphaeurekaselec_live_10_06_2022Subject.php#238
        Backtrace
        • 14. app/Models/Subject.php:238
        • 15. app/Http/Controllers/EbookVolumeController.php:1574
        • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
        • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
        • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • select count(*) as aggregate from `subject_journal` as `sj` inner join `journal` as `j` on `j`.`journal_id` = `sj`.`journal_id` where subject_id IN (select subject_id FROM subject_ebook WHERE ebook_id=185)
        750μsalphaeurekaselec_live_10_06_2022Subject.php#255
        Backtrace
        • 16. app/Models/Subject.php:255
        • 17. app/Http/Controllers/EbookVolumeController.php:1575
        • 18. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
        • 19. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
        • 20. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • select distinct j.nid as journal_nid,j.title,j.subtitle,j.issn,j.eissn,j.keyword,sj.journal_id,j.image_file_name,j.flyer_link from `subject_journal` as `sj` inner join `journal` as `j` on `j`.`journal_id` = `sj`.`journal_id` where subject_id IN (select subject_id FROM subject_ebook WHERE ebook_id=185) limit 10 offset 20
        750μsalphaeurekaselec_live_10_06_2022Subject.php#255
        Backtrace
        • 14. app/Models/Subject.php:255
        • 15. app/Http/Controllers/EbookVolumeController.php:1575
        • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
        • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
        • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • select CONCAT_WS(' ',au.first_name, ' ', ifnull(au.initials,''), ' ', au.last_name) as authors, CONCAT(au.last_name, IFNULL(CONCAT(' ', au.initials), ''), ' ', au.first_name) AS authorsRIS, CONCAT_WS(' ',au.last_name, ' ', ifnull(au.initials,''), ' ', au.first_name) as authorsCiteAs, CONCAT_WS(' ',au.first_name, IFNULL(CONCAT(' ', au.initials), ''), IFNULL(CONCAT(' ', au.last_name), '')) as authorsmodal , `au`.*, `af`.`ror_id`, `af`.`institution`, `af`.`department`, `af`.`country`, `af`.`city`, `af`.`address`, (GROUP_CONCAT(TRIM(BOTH ', ' FROM CONCAT(ifnull(concat(af.institution,','),''), ifnull(concat(af.department,','),''), ifnull(concat(af.address,','),''), ifnull(concat(af.city,','),''), ifnull(concat(af.country,','),''), ifnull(concat(af.postal_code,','),''), ifnull(concat(af.phone,','),''), ifnull(concat(af.fax,','),''))) SEPARATOR '|')) as `author_affiliation`, (GROUP_CONCAT(TRIM(BOTH ', ' FROM CONCAT(ifnull(concat(af.web_view,','),''))) SEPARATOR '|')) as `web_view` from `author` as `au` left join `author_affiliation` as `af` on `au`.`author_id` = `af`.`author_id` where `au`.`ebook_volume_id` = '983' group by `au`.`author_id` order by `au`.`article_id` asc, `au`.`sequence` asc
        830μsalphaeurekaselec_live_10_06_2022Author.php#86
        Bindings
        • 0: 983
        Backtrace
        • 13. app/Models/Author.php:86
        • 14. app/Http/Controllers/EbookVolumeController.php:1919
        • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
        • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
        • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • select b.banner_link, b.banner_name, b.banner_script, b.banner_remarks, b.banner_file_name, b.banner_placement, bd.content_type, bd.content_id from `tbl_banner` as `b` inner join `tbl_banner_detail` as `bd` on `bd`.`banner_id` = `b`.`banner_id` inner join `users` as `u` on `u`.`id` = `b`.`updated_by` where `b`.`banner_ebook` = 1 and `bd`.`content_type` = 'B' and `bd`.`content_id` = 983 and `b`.`banner_from_date` <= 1740676946 and `b`.`banner_to_date` >= 1740676946 and `b`.`banner_status` = 'A' order by `b`.`banner_id` desc
        1.1msalphaeurekaselec_live_10_06_2022Banner.php#95
        Bindings
        • 0: 1
        • 1: B
        • 2: 983
        • 3: 1740676946
        • 4: 1740676946
        • 5: A
        Backtrace
        • 13. app/Models/Banner.php:95
        • 14. app/Http/helpers.php:404
        • 17. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
        • 18. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
        • 19. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
      • select b.banner_link, b.banner_name, b.banner_script, b.banner_remarks, b.banner_file_name, b.banner_placement, bd.content_type, bd.content_id from `tbl_banner` as `b` inner join `tbl_banner_detail` as `bd` on `bd`.`banner_id` = `b`.`banner_id` inner join `users` as `u` on `u`.`id` = `b`.`updated_by` where `b`.`banner_ebook` = 1 and `bd`.`content_type` = 'B' and `bd`.`content_id` = 983 and `b`.`banner_from_date` <= 1740676946 and `b`.`banner_to_date` >= 1740676946 and `b`.`banner_status` = 'A' order by `b`.`banner_id` desc
        1.06msalphaeurekaselec_live_10_06_2022Banner.php#95
        Bindings
        • 0: 1
        • 1: B
        • 2: 983
        • 3: 1740676946
        • 4: 1740676946
        • 5: A
        Backtrace
        • 13. app/Models/Banner.php:95
        • 14. app/Http/helpers.php:404
        • 17. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
        • 18. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
        • 19. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
      • select count(*) as aggregate from `uc_cart_products` where cart_id='fef7c6fbf53f26e74311082836b4cd46'
        250μsalphaeurekaselec_live_10_06_2022Cart.php#271
        Backtrace
        • 15. app/Models/Cart.php:271
        • 16. view::layouts._header:260
        • 18. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
        • 19. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
        • 20. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
      App\Models\Ebook
      1Ebook.php#?
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          ClearShow all
          Date ↕MethodURLData
          #12025-02-27 17:22:26GET/ebook_volume/983/related-journals?page=310181