Host defense to intracellular pathogens depends upon both innate and adaptive cell-mediated immune responses. Polymorphonuclear neutrophil leukocytes which belong to the innate immune system are the first cells that are recruited massively within hours of microbial infection. The importance of neutrophils in the development of an immune response is only emerging as they have long been considered by immunologists as short lived, non-dividing cells, of poor interest. Now, neutrophils are emerging as key components of the inflammatory response, and are shown to have immunoregulatory roles in microbial infections. The impact of neutrophils on cells present at the site of infection is only beginning to be studied and deserves more attention. This e-book provides an overview of the recent advances made in the field of neutrophil biology and motions towards some of the exciting new directions in which neutrophil research is moving.

This book introduces personalized immunotherapy with multi-dimensional models of analysis to determine the best plan for immunotherapy of patients. The book introduces readers to some basic concepts which lay the foundation for personalized immunotherapy: the development of a major histocompatibility complex (MHC), the genome profile of T cells and tumor cells, and genome-wide association studies. Chapters also cover special topics such as new immunoassay methods related to personalized immunotherapy and targeted immunotherapy which are geared towards familiarizing readers with current research practices. Focusing on the central theme of personalized immunotherapy, the authors provide a wealth of information about T-cell screening, tumor neoantigen cloning, primary tumor cell culture for T-cell cloning, bioinformatics strategies for understanding T-cell and primary tumor cell biology and function, and new developments in research on adoptive T-cell immunotherapy. These developments include T-cell gene therapy and T-cell gene editing, transgenic T-cells for increasing affinity to tumor cells such as CAR T-cells and TCR T-cells, and the systematic modeling of polyclonal specific T-cells and biobank technology. Key Features: - Introduces readers to basic concepts in personalized medicine and immunotherapy - Presents current information about immunological assays used in research - Presents an overview of T cell immunotherapy and cloning techniques - Presents an overview of tumor cell bioinformatics and its role in immunotherapy - Includes new developments and references for personalized immunotherapy techniques (T-cell gene therapy and T-cell gene editing, transgenic T-cells which target CAR T-cells and TCR T-cells, and polyclonal T-cell modeling) - Includes a section on biobanking - Presents information in an easy-to-read format for a wide range of readers - Brings contributions from experts with over 30 years of experience in personalized immunotherapy Personalized Immunotherapy for Tumor Diseases and Beyond is an ideal handbook for medical professionals and students involved in personalized medicine, immunology and oncology. General readers interested in the new developments in these fields will also benefit from the information provided.

The book is dedicated to the history and current status of physiologic autoimmunity concept and relation between autoimmunity and autoallergy in the context of disease prevention and prediction. The immune system is a natural component, regulator and direct participant in the physiological activities in a healthy body. The main forms of physiological activity of the immune system are based on the intrinsic abilities of self-identification, self-maintenance, self-regulation, and self-reparation — that is recognizing components of the “self ”, i.e. natural autoimmunity. The most ancient and homeostatically important functions of natural autoimmunity are autoclearance as well as construction and support of multicellularity. A considerable number of immune functions, including those related to antimicrobial defense, derive from these basic ones. Various pathological processes in any organ are usually accompanied by different patterns of cell death and, thus, by increased exposure and presentation of self antigens. These events induce the secondary rise in production of autoantibodies with appropriate specificity (opsonines), which provides augmentation of clearance by facilitating the efficacy of macrophage-dependent consumption of debris in the aff ected organ. This phenomenon is sanogenic in nature and adaptive in essence. Therefore, secondary changes in production and serum content of autoantibodies can be considered the universal and earliest detectable marker of any chronic disease. In relation to experimental production and clinical reveal of antibodies towards nuclear antigens, penetrating into living cell nuclei and altering nuclear acid synthesis, cell proliferation and function, autoantibodies can be regarded as hormone-like bioregulators of gene expression. Apparently, immune system is able to reproduce complementary regulators for various cell receptors, including nuclear ones. Book is unique, it is a single monograph comprehensively including history and current status of natural autoimmunity problem. It describes a fundamental concept essencial for every branch of Medicine and Pathology. The concept described has broad practical application for Health Care, because it establishes effective method of early prediction for many different diseases, creates a basis for prophylaxis. Reader has a chance to get rid of old dogmas and acquire new instrument for fruitful theoretical reasoning, research planning and predictive/preventive practical medical work.

Human Immunodeficiency Virus (HIV) infection represents one of the biggest challenges of current years. However, scientists and physicians still do not have an efficient therapy for preventing or eradicating the virus. The selection of drug-resistant strains as well as side-effects, represent common problems encountered in all anti-viral therapies. However, it has been clearly demonstrated that the potency of early immune responses profoundly regulates levels of HIV, and hence also the generation of virus mutants as well as the velocity of disease progression to AIDS. A prominent feature of this e-book is the focus on interaction between innate immunity and HIV infection. This topic has been investigated by many authors from the late 80's, and many soluble factors responsible for such activity have been discovered, such as suPAR and HMGB1. At present, these two novel factors are the subject of very intense research on HIV infections. A key advantage of this e-book is the selection of authors, recognized worldwide as leading experts in their field. Because of the comprehensive coverage, as well as the eminence of the authors, this e-book provides a detailed and high quality description about the role of innate immune responses regulating HIV replication. It should prove to be a useful resource for readers interested in immunology and HIV research.