Mixed Polymeric Micelles for Osteosarcoma Therapy: Development and Characterization

Author(s) : Catarina Melim, Ana Figueiras, Ivana Jarak, Ana Isabel Santos

DOI: 10.2174/97898150403711220101
eISBN: 978-981-5040-37-1, 2022
ISBN: 978-981-5040-38-8

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Request history8.2.27PHP Version237msRequest Duration27MBMemory UsageGET ebook_volume/{id}/{page_name?}/{param?}Route
  • warninglog[18:05:39] LOG.warning: ucfirst(): Passing null to parameter #1 ($string) of type string is deprecat...
  • warninglog[18:05:39] LOG.warning: ucfirst(): Passing null to parameter #1 ($string) of type string is deprecat...
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  • warninglog[18:05:39] LOG.warning: ucfirst(): Passing null to parameter #1 ($string) of type string is deprecat...
  • Booting (137ms)time
  • Application (99.41ms)time
  • 1 x Booting (58%)
    137ms
    1 x Application (41.99%)
    99.41ms
    10 templates were rendered
    • ebook.ebook_volume_relatedebook_volume_related.blade.php#?blade
    • layouts.ebook_volume_header_sectionebook_volume_header_section.blade.php#?blade
    • ...related_ebooksrelated_ebooks.blade.php#?blade
    • pagination::bootstrap-4bootstrap-4.blade.php#?blade
    • ebook.ebook_right_bannerebook_right_banner.blade.php#?blade
    • layouts.appapp.blade.php#?blade
    • layouts._login_access_login_access.blade.php#?blade
    • layouts._header_header.blade.php#?blade
    • layouts._main_menu_main_menu.blade.php#?blade
    • layouts._footer_menu_footer_menu.blade.php#?blade
    uri
    GET ebook_volume/{id}/{page_name?}/{param?}
    middleware
    web, check_user_access
    controller
    App\Http\Controllers\EbookVolumeController@GetEbookVolumeDetails
    namespace
    App\Http\Controllers
    where
    as
    ebook_volume
    file
    app/Http/Controllers/EbookVolumeController.php:1486-1958
    18 statements were executed, 2 of which were duplicates, 16 unique. Show only duplicated24.71ms
    • Connection Establishedalphaeurekaselec_live_10_06_2022UserAccessCheck.php#24
      Backtrace
      • 9. middleware::check_user_access:24
      • 10. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 11. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 12. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 13. vendor/laravel/framework/src/Illuminate/Foundation/Http/Middleware/VerifyCsrfToken.php:88
    • INSERT INTO visitor_ip_address (ip_address,visitor_agent,visitor_count, created_on,updated_on) VALUES ('314566045','',1,1739988339,1739988339) ON DUPLICATE KEY UPDATE visitor_count=visitor_count + 1, updated_on=1739988339
      2msalphaeurekaselec_live_10_06_2022UserAccessCheck.php#24
      Backtrace
      • 11. middleware::check_user_access:24
      • 12. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 14. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 15. vendor/laravel/framework/src/Illuminate/Foundation/Http/Middleware/VerifyCsrfToken.php:88
    • INSERT INTO visitor_ip_address_detail (ip_address,visitor_url,visitor_count, created_on,updated_on) VALUES ('314566045','/ebook_volume/3313/related-ebooks?page=9',1,1739988339,1739988339)
      260μsalphaeurekaselec_live_10_06_2022UserAccessCheck.php#27
      Backtrace
      • 11. middleware::check_user_access:27
      • 12. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 14. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 15. vendor/laravel/framework/src/Illuminate/Foundation/Http/Middleware/VerifyCsrfToken.php:88
    • (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_journal_volume_trail WHERE to_ip >= 314566045 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 314566045) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_journal_volume_corporate WHERE to_ip >= 314566045 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 314566045) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_journal_volume_token WHERE to_ip >= 314566045 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 314566045) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_ebook_volume_trail WHERE to_ip >= 314566045 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 314566045) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_ebook_volume_corporate WHERE to_ip >= 314566045 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 314566045) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_ebook_volume_token WHERE to_ip >= 314566045 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 314566045) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_issue_trail WHERE to_ip >= 314566045 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 314566045) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_issue_corporate WHERE to_ip >= 314566045 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 314566045) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_issue_token WHERE to_ip >= 314566045 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 314566045) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_article_trail WHERE to_ip >= 314566045 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 314566045) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_article_corporate WHERE to_ip >= 314566045 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 314566045) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_article_token WHERE to_ip >= 314566045 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 314566045) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_chapter_trail WHERE to_ip >= 314566045 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 314566045) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_chapter_corporate WHERE to_ip >= 314566045 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 314566045) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_chapter_token WHERE to_ip >= 314566045 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 314566045) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_disease_corporate WHERE to_ip >= 314566045 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 314566045) limit 1
      11.86msalphaeurekaselec_live_10_06_2022UserAccess.php#784
      Bindings
      • 0: 314566045
      • 1: 314566045
      • 2: 314566045
      • 3: 314566045
      • 4: 314566045
      • 5: 314566045
      • 6: 314566045
      • 7: 314566045
      • 8: 314566045
      • 9: 314566045
      • 10: 314566045
      • 11: 314566045
      • 12: 314566045
      • 13: 314566045
      • 14: 314566045
      • 15: 314566045
      Backtrace
      • 14. app/Models/UserAccess/UserAccess.php:784
      • 15. middleware::check_user_access:114
      • 16. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 18. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
    • select `year`, `id` from `year` order by `year` asc
      320μsalphaeurekaselec_live_10_06_2022Journal.php#197
      Backtrace
      • 13. app/Models/Journal.php:197
      • 14. app/Http/Controllers/EbookVolumeController.php:1555
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select `e`.*, `a`.*, `y`.`year`, `e`.`ebook_volume_id` as `ebook_volume_id`, `a`.`ebook_volume_id` as `ebk_vol_id`, `e`.`ebook_id` as `ebk_ebook_id` from `ebook_volume` as `e` left join `author` as `a` on `e`.`ebook_volume_id` = `a`.`ebook_volume_id` left join `year` as `y` on `y`.`id` = `e`.`year_id` where `e`.`ebook_volume_id` = '3313' and `e`.`is_uploaded` = 1
      690μsalphaeurekaselec_live_10_06_2022EbookVolume.php#271
      Bindings
      • 0: 3313
      • 1: 1
      Backtrace
      • 13. app/Models/EbookVolume.php:271
      • 14. app/Http/Controllers/EbookVolumeController.php:1556
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select `ie`.`index_id`, `ie`.`ebook_volume_id`, `i`.`title` from `indexing_ebook` as `ie` left join `indexing_agencies` as `i` on `ie`.`index_id` = `i`.`index_id` where `ie`.`ebook_volume_id` = '3313' and `i`.`status` = 1 order by `i`.`title` asc
      310μsalphaeurekaselec_live_10_06_2022Indexing.php#345
      Bindings
      • 0: 3313
      • 1: 1
      Backtrace
      • 13. app/Models/Indexing.php:345
      • 14. app/Http/Controllers/EbookVolumeController.php:1557
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select count(*) as aggregate from (select `chapter`.*, group_concat(a.first_name,' ',a.last_name) as author_name from `chapter` left join `author` as `a` on `a`.`chapter_id` = `chapter`.`chapter_id` where `chapter`.`ebook_volume_id` = '3313' and `chapter`.`is_uploaded` = 1 group by `chapter`.`chapter_id`) as `aggregate_table`
      730μsalphaeurekaselec_live_10_06_2022Chapter.php#97
      Bindings
      • 0: 3313
      • 1: 1
      Backtrace
      • 16. app/Models/Chapter.php:97
      • 17. app/Http/Controllers/EbookVolumeController.php:1568
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 19. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 20. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select `chapter`.*, group_concat(a.first_name,' ',a.last_name) as author_name from `chapter` left join `author` as `a` on `a`.`chapter_id` = `chapter`.`chapter_id` where `chapter`.`ebook_volume_id` = '3313' and `chapter`.`is_uploaded` = 1 group by `chapter`.`chapter_id` order by `chapter`.`chapter_no` asc limit 100 offset 800
      630μsalphaeurekaselec_live_10_06_2022Chapter.php#97
      Bindings
      • 0: 3313
      • 1: 1
      Backtrace
      • 14. app/Models/Chapter.php:97
      • 15. app/Http/Controllers/EbookVolumeController.php:1568
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from `ebook` where `ebook_id` = 957 limit 1
      270μsalphaeurekaselec_live_10_06_2022EbookVolumeController.php#1570
      Bindings
      • 0: 957
      Backtrace
      • 16. app/Http/Controllers/EbookVolumeController.php:1570
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 19. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • 20. vendor/laravel/framework/src/Illuminate/Routing/Route.php:206
    • select count(*) rcd from `ebook_volume` where `ebook_id` = 957 and ebook_volume_id <> 3313 limit 1
      360μsalphaeurekaselec_live_10_06_2022EbookVolume.php#999
      Bindings
      • 0: 957
      Backtrace
      • 14. app/Models/EbookVolume.php:999
      • 15. app/Http/Controllers/EbookVolumeController.php:1571
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select count(*) as aggregate from `subject_ebook` as `se` inner join `ebook` as `e` on `e`.`ebook_id` = `se`.`ebook_id` inner join `ebook_volume` as `v` on `v`.`ebook_id` = `e`.`ebook_id` where subject_id IN (select subject_id FROM subject_ebook WHERE ebook_id=957) and se.ebook_id!=957 and v.ebook_status='1'
      860μsalphaeurekaselec_live_10_06_2022Subject.php#238
      Backtrace
      • 16. app/Models/Subject.php:238
      • 17. app/Http/Controllers/EbookVolumeController.php:1574
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 19. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 20. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select distinct v.nid as volume_id,e.nid,e.title,v.issn,v.eissn,v.isbn,v.eisbn,e.ebook_id, v.image_file_name,v.file_path,v.flyer_link,v.ebook_volume_id, v.volume_name,v.doi,v.year_id,v.introduction from `subject_ebook` as `se` inner join `ebook` as `e` on `e`.`ebook_id` = `se`.`ebook_id` inner join `ebook_volume` as `v` on `v`.`ebook_id` = `e`.`ebook_id` where subject_id IN (select subject_id FROM subject_ebook WHERE ebook_id=957) and se.ebook_id!=957 and v.ebook_status='1' limit 10 offset 80
      2.19msalphaeurekaselec_live_10_06_2022Subject.php#238
      Backtrace
      • 14. app/Models/Subject.php:238
      • 15. app/Http/Controllers/EbookVolumeController.php:1574
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select count(*) as aggregate from `subject_journal` as `sj` inner join `journal` as `j` on `j`.`journal_id` = `sj`.`journal_id` where subject_id IN (select subject_id FROM subject_ebook WHERE ebook_id=957)
      410μsalphaeurekaselec_live_10_06_2022Subject.php#255
      Backtrace
      • 16. app/Models/Subject.php:255
      • 17. app/Http/Controllers/EbookVolumeController.php:1575
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 19. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 20. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select distinct j.nid as journal_nid,j.title,j.subtitle,j.issn,j.eissn,j.keyword,sj.journal_id,j.image_file_name,j.flyer_link from `subject_journal` as `sj` inner join `journal` as `j` on `j`.`journal_id` = `sj`.`journal_id` where subject_id IN (select subject_id FROM subject_ebook WHERE ebook_id=957) limit 10 offset 80
      530μsalphaeurekaselec_live_10_06_2022Subject.php#255
      Backtrace
      • 14. app/Models/Subject.php:255
      • 15. app/Http/Controllers/EbookVolumeController.php:1575
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select CONCAT_WS(' ',au.first_name, ' ', ifnull(au.initials,''), ' ', au.last_name) as authors, CONCAT(au.last_name, IFNULL(CONCAT(' ', au.initials), ''), ' ', au.first_name) AS authorsRIS, CONCAT_WS(' ',au.last_name, ' ', ifnull(au.initials,''), ' ', au.first_name) as authorsCiteAs, CONCAT_WS(' ',au.first_name, IFNULL(CONCAT(' ', au.initials), ''), IFNULL(CONCAT(' ', au.last_name), '')) as authorsmodal , `au`.*, `af`.`ror_id`, `af`.`institution`, `af`.`department`, `af`.`country`, `af`.`city`, `af`.`address`, (GROUP_CONCAT(TRIM(BOTH ', ' FROM CONCAT(ifnull(concat(af.institution,','),''), ifnull(concat(af.department,','),''), ifnull(concat(af.address,','),''), ifnull(concat(af.city,','),''), ifnull(concat(af.country,','),''), ifnull(concat(af.postal_code,','),''), ifnull(concat(af.phone,','),''), ifnull(concat(af.fax,','),''))) SEPARATOR '|')) as `author_affiliation`, (GROUP_CONCAT(TRIM(BOTH ', ' FROM CONCAT(ifnull(concat(af.web_view,','),''))) SEPARATOR '|')) as `web_view` from `author` as `au` left join `author_affiliation` as `af` on `au`.`author_id` = `af`.`author_id` where `au`.`ebook_volume_id` = '3313' group by `au`.`author_id` order by `au`.`article_id` asc, `au`.`sequence` asc
      740μsalphaeurekaselec_live_10_06_2022Author.php#86
      Bindings
      • 0: 3313
      Backtrace
      • 13. app/Models/Author.php:86
      • 14. app/Http/Controllers/EbookVolumeController.php:1919
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select b.banner_link, b.banner_name, b.banner_script, b.banner_remarks, b.banner_file_name, b.banner_placement, bd.content_type, bd.content_id from `tbl_banner` as `b` inner join `tbl_banner_detail` as `bd` on `bd`.`banner_id` = `b`.`banner_id` inner join `users` as `u` on `u`.`id` = `b`.`updated_by` where `b`.`banner_ebook` = 1 and `bd`.`content_type` = 'B' and `bd`.`content_id` = 3313 and `b`.`banner_from_date` <= 1739988339 and `b`.`banner_to_date` >= 1739988339 and `b`.`banner_status` = 'A' order by `b`.`banner_id` desc
      1.11msalphaeurekaselec_live_10_06_2022Banner.php#95
      Bindings
      • 0: 1
      • 1: B
      • 2: 3313
      • 3: 1739988339
      • 4: 1739988339
      • 5: A
      Backtrace
      • 13. app/Models/Banner.php:95
      • 14. app/Http/helpers.php:404
      • 17. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 18. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    • select b.banner_link, b.banner_name, b.banner_script, b.banner_remarks, b.banner_file_name, b.banner_placement, bd.content_type, bd.content_id from `tbl_banner` as `b` inner join `tbl_banner_detail` as `bd` on `bd`.`banner_id` = `b`.`banner_id` inner join `users` as `u` on `u`.`id` = `b`.`updated_by` where `b`.`banner_ebook` = 1 and `bd`.`content_type` = 'B' and `bd`.`content_id` = 3313 and `b`.`banner_from_date` <= 1739988339 and `b`.`banner_to_date` >= 1739988339 and `b`.`banner_status` = 'A' order by `b`.`banner_id` desc
      1.14msalphaeurekaselec_live_10_06_2022Banner.php#95
      Bindings
      • 0: 1
      • 1: B
      • 2: 3313
      • 3: 1739988339
      • 4: 1739988339
      • 5: A
      Backtrace
      • 13. app/Models/Banner.php:95
      • 14. app/Http/helpers.php:404
      • 17. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 18. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    • select count(*) as aggregate from `uc_cart_products` where cart_id='58b5a316797a51b0df058417d5a1316c'
      300μsalphaeurekaselec_live_10_06_2022Cart.php#271
      Backtrace
      • 15. app/Models/Cart.php:271
      • 16. view::layouts._header:260
      • 18. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 20. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    App\Models\Ebook
    1Ebook.php#?
        _token
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