This is the fourth volume of the eBook Series entitled Topics in Anti-Cancer Research. This volume covers new research as well as updated chapters on topics relevant to modern cancer research published in the journal Recent Patents on Anti-Cancer Drug Discovery. Interesting diverse methods, new technologies and fast developing areas in the field of anti-cancer research are presented. The topics included in the present volume will be of great value to clinicians, scientists and R&D experts aiming to learn more about the latest developments and new alternatives for different types of cancer treatment. The use of gold macro rods and ultrasound for cancer treatment with hyperthermia, obesity associated breast cancer, and the role of cytokines and chemokines pathways in studying cancer immunotherapy are discussed. The mechanism of antibody-drug and antibody-toxin conjugates alongwith clinical trials research, significance of transforming growth factor-beta and urokinase type plasminogen activator in tumorigenesis and reverstol studies in oncohematological disorders are also presented. Other important areas covered include the discovery of novel compounds, drugs and chemotherapeutics in the treatment of lung cancer, biological functions of cell surface nucleolin in cancer, polymeric nanosystems and nanosystem applications used for anticancer drug therapy. Recent advances in development of new potent tubulin inhibitors and structures of molecular hybrids and their actions in different cell lines have also been discussed. All these studies focused are supported by recent associated patents The topics covered in this fourth volume will be of immense interest for those researchers and scientists looking for new techniques, targets, drugs, compounds and drug delivery methods for various types of cancer and its control.

The fifth volume of this series entitled “Topics in Anti-Cancer Research” presents an overview of recent developments in the field of cancer. The topics covered include regulatory policies, cell based anticancer drug delivery systems, anticancer agents targeting heat shock proteins, and tumor homing peptides (THPs) for treatment of cancer.

Topics in Anti-Cancer Research covers important advances on both experimental (preclinical) and clinical cancer research in drug development. The book series offers readers an insight into current and future therapeutic approaches for the prevention of different types of cancers, synthesizing new anti-cancer agents, new patented compounds, targets and agents for cancer therapy as well as recent molecular and gene therapy research. The comprehensive range of themes covered in each volume will be beneficial to clinicians, immunologists, and R&D experts looking for new anti-cancer targets and patents for the treatment of neoplasms, as well as varied approaches for cancer therapy.

Topics in Anti-Cancer Research covers important advances on both experimental (preclinical) and clinical cancer research in drug development. The book series offers readers an insight into current and future therapeutic approaches for the prevention of different types of cancers, synthesizing new anti-cancer agents, new patented compounds, targets and agents for cancer therapy as well as recent molecular and gene therapy research.</p> <p> The comprehensive range of themes covered in each volume will be beneficial to clinicians, immunologists, and R&D experts looking for new anti-cancer targets and patents for the treatment of neoplasms, as well as varied approaches for cancer therapy.</p> <p> The topics covered in the seventh volume of this series include: - The role of inflammation in chemotherapy-induced neuromuscular effects - Advances in nutrigenomics and relevant anti-cancer patents - Stimuli-responsive nanocarriers for on-demand anti-cancer drug release - Harnessing biochemical mechanisms that control autophagy for treating esophageal cancer.</p>

Topics in Anti-Cancer Research covers new developments in the field of cancer. Novel drugs as anticancer agents include natural and synthetic phenazines and other anti-cancer compounds. It also encompasses the role of estrogen as endocrine disruptors and strategies targeting cancer stem cells for the treatment of different types of cancers, including myeloma and renal cell cancer. <p></p> The diversity of researches and topics published in this eBook Series will be valuable to cancer researchers, clinicians, and cancer professionals aiming to develop novel anti-cancer targets for the treatment of various cancers. <p></p> The topics covered in the eighth volume of this series are as follows: <p></p> -Novel Drugs for Multiple Myeloma <p></p> -Synthetic Estrogens are Endocrine Disruptors via Inhibition of AF1 Domain of ERs <p></p> -Recent Progress of Phenazines as Anticancer Agents <p></p> -Cancer Stem Cell Targeting for Anticancer Therapy: Strategies and Challenges

Topics in Anti-Cancer Research covers new developments in the field of cancer diagnosis and drug therapy. Novel drugs as anticancer agents include natural and synthetic phenazirines and other anti-cancer compounds. The series also covers information on the current understanding of the pathology and molecular biology of specific neoplasms. The diversity of research topics published in this book series give broad and valuable perspectives for cancer researchers, clinicians, cancer professionals aiming to develop novel anti-cancer targets and patents for the treatment of various cancers. The topics covered in this volume are: - Recent Patents on Exosome-Derived Therapeutic Agents - Serrated Lesions of the Colon and Rectum: An Overview of Pathology and Emphasis on a New Classification - Introducing the 188W/188Re and 144Ce/144Pr Plaques for Eye Cancers Brachytherapy - ShcA Family of Adaptor Proteins: Dual Role in Cell Growth - Hormones Management as Anticancer Treatment and Protection: Functions and Mechanism of Action

Topics in Anti-Cancer Research covers new developments in the field of cancer diagnosis and drug therapy. Novel drugs as anticancer agents include natural and synthetic phenazirines and other anti-cancer compounds. The series also covers information on the current understanding of the pathology and molecular biology of specific neoplasms. <p> The diversity of research topics published in this book series give broad and valuable perspectives for cancer researchers, clinicians, cancer professionals aiming to develop novel anti-cancer targets and patents for the treatment of various cancers. <p> The topics covered in this volume are: <p> - Peptides can play a major role in combating cancer diseases <p> - Studying of the CLL after treatment using fractal parameter of neoplastic lymphocytes detection (ΛNLD) <p> - Mechanistic insight of rhenium-based compounds as anti- cancer agents <p> - Targeting cancer-specific inflammatory components in cancer therapeutics <p> - Marine natural products as a source of novel anticancer agents: a treasure from the ocean <p> - PDX clinical trial design in anti-cancer research

The technological level of upper limb prostheses has always been fairly poor so far if compared with that of other analogous systems (e.g. lower limb prostheses, assistive robots). However, there is no doubt that in the recent years the upper limb research stimulated the most exciting developments in prosthetic technology. Indeed, new terminal devices and novel articulations for the artificial arm have been recently proposed, and the control hardware, software and firmware are in continuous progress for the implementation of effective control options for the wearers as well as for an easier management of the electronic boards. Also the clinical treatment of the patients is significantly improving. This e-book illustrates significant milestones reached by the scientists in prosthetic research considering both technical issues and clinical features, and also sheds lights on new trends and future developments of this field.

A break in the proximal part of the tibia or shinbone region results in a Tibial plateau fracture. This type of bone damage results in the impaired motion and stability of the leg and the knee joint. Since this is a critical load-bearing region of the body, patients affected by these fractures have difficulty in carrying their body weight, which can cause major disability. Tibial plateau fractures commonly occur as a result of motor vehicle accidents in younger individuals and as a result of osteoporosis in elderly women. With appropriate medical guidance, patient rehabilitation is possible. This book is a concise handbook on key information about the diagnosis and treatment of Tibial plateau fractures. Chapters in this book cover the epidemiology of these types of bone fractures, diagnostic imaging, surgical treatment options and patient rehabilitation. The book is intended as a primer on Tibial plateau fractures for medical students and novice surgeons who aim to specialize in orthopaedic surgery. Readers will be able to understand how to manage relevant bone fracture cases which they encounter and will learn how to improve patient recovery after surgical procedures

The electrical response of cells to mechanical stimulus is known as mechanotransduction. This monograph is a summary of the mechanotransduction in musculoskeletal cells responsible for body tissue maintenance, support, cover and movement. While mechanotransduction is similar among these cells, there are also several important differences in mechanical parameters and cellular pathways characteristic to each cell type. Therefore, readers will have the opportunity to update their knowledge about the increasing volume of information on mechanotransduction in these cells gained from current research. The book features a primer on general aspects of cellular biomechanics and the experimental methods and equipment commonly used for investigating cellular mechanotransduction in vitro in two dimensional cultures in which cells are adherent to plastic surfaces. Characteristic mechanotransduction pathways in mesenchymal stem cells (MSCs), chondrocytes, osteoblasts and fibroblasts are described in the accompanying chapters. Finally, a description of clinical implementation of mechanical stimulation is presented with emphasis on distraction osteogenesis, involving osteoblast stimulation, and skin stretching techniques based on fibroblast stimulation. This monograph is a useful reference for readers involved in graduate courses or basic research in cell biology and musculoskeletal physiology.