Abstract
The well-known antimalarial properties of naturally occurring cyclic peroxides artemisinin (qinghaosu), yingzhaosu A and yingzhaosu C have stimulated the development of new strategies for the synthesis of cyclic peroxides with diverse structures, and the investigation of the chemical transformations and properties of such compounds. In this review, recent progress in the chemistry of mono- and polycyclic organic peroxides with ring sizes of five or greater is highlighted and discussed.
Keywords: Cyclic Peroxides, artemisinin, photo-oxygenation, 1,2-DIOXOLANES, spirodioxolane, allylstannane, Alkoxy-1,2-dioxolanes, oxatrimethylene diradical, diastereoisomeric, hydroperoxide, aminophthalamide, TMSOTf-catalysed cyclocondensation, 1,4-bis(dihydroquinine)phthalazine, hexafluorophosphate, diisobutylaluminium hydride, N-iodosuccinimide, trimethylsilyl triflate, 2,2,6,6-tetramethyl-1-piperidinyloxy
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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