Login Register Cart 0
Generic placeholder image

The Natural Products Journal

Editor-in-Chief

ISSN (Print): 2210-3155
ISSN (Online): 2210-3163

Back
Journal Home About Journal Editorial Board Journal Insight Current Issue Volumes/Issues
Subscribe
Review Article

Urtica dioica in the Management of Benign Prostate Hyperplasia (BPH)

Author(s): Mohaddese Mahboubi*

Volume 10, Issue 5, 2020

Page: [535 - 542] Pages: 8

DOI: 10.2174/2210315509666190723125509

Price: $65

Abstract

Background: Benign Prostatic hyperplasia (BPH) is known as a disease prevalent in men after the age of 50 years old. Ninety percent of men with the age of 80 years and over have BPH. BPH is associated with functional problems like dysuria, nocturia, polyuria, urinary incontinence and recurrent urinary tract infections. Urtica dioica or nettle is a popular medicinal plant for management of BPH in men.

Objective: This article evaluates the efficacy and safety of nettle and its related possible mechanisms in the management of BPH.

Methods: For the preparation of this manuscript, all the information was gathered from accessible and inaccessible resources (Web, Books, Thesis, etc.).

Results: The results of preclinical and clinical studies confirmed the efficacy of nettle roots extracts (methanol, ethanol, and petroleum ether) in the improvement of BPH in term of IPSS score, and patient's life quality. An increase in mean and maximum urinary flow rates and a reduction in prostate volume and residual urine level were observed after treatment with nettle extract. Nettle roots should be used for 6-12 months as its use is possible for a long time without any serious adverse effects.

Conclusion: Designing the clinical trials to compare the efficacy of different extracts from roots or leaves and investigation of molecular mechanisms of action could be the approaches for future.

Keywords: Benign Prostatic hyperplasia, BPH, Nettle, Urtica dioica, urinary incontinence, urinary tract infections.

Graphical Abstract

[1]
Sausville, J.; Naslund, M. Benign prostatic hyperplasia and prostate cancer: An overview for primary care physicians. Int. J. Clin. Pract., 2010, 64(13), 1740-1745.
[http://dx.doi.org/10.1111/j.1742-1241.2010.02534.x ] [PMID: 21070524]
[2]
Chughtai, B.; Forde, J.C.; Thomas, D.D.M.; Laor, L.; Hossack, T.; Woo, H.H.; Te, A.E.; Kaplan, S.A. Benign prostatic hyperplasia. Nat. Rev. Dis. Primers, 2016, 2, 16031.
[http://dx.doi.org/10.1038/nrdp.2016.31 ] [PMID: 27147135]
[3]
Skinder, D.; Zacharia, I.; Studin, J.; Covino, J. Benign prostatic hyperplasia: A clinical review. JAAPA, 2016, 29(8), 19-23.
[http://dx.doi.org/10.1097/01.JAA.0000488689.58176.0a ] [PMID: 27367595]
[4]
Kapoor, A. Benign prostatic hyperplasia (BPH) management in the primary care setting. Can. J. Urol., 2012, 19(Suppl. 1), 10-17.
[PMID: 23089343]
[5]
Hirano, T.; Homma, M.; Oka, K. Effects of stinging nettle root extracts and their steroidal components on the Na+, K(+)-ATPase of the benign prostatic hyperplasia. Planta Med., 1994, 60(1), 30-33.
[http://dx.doi.org/10.1055/s-2006-959402 ] [PMID: 7510891]
[6]
Akbay, P.; Basaran, A.A.; Undeger, U.; Basaran, N. In vitro immunomodulatory activity of flavonoid glycosides from Urtica dioica L. Phytother. Res., 2003, 17(1), 34-37.
[http://dx.doi.org/10.1002/ptr.1068 ] [PMID: 12557244]
[7]
Ahmed, K.K.M.; Parsuraman, S. Urtica dioica L.(Urticaceae): A stinging nettle. Syst. Rev. Pharm., 2014, 5(1), 6-8.
[http://dx.doi.org/10.5530/srp.2014.1.3]
[8]
Grieve, M. A modern herbal. Courier corporation: North Chelmsford, Massachusetts, USA, 2013, 2..
[9]
Biró-Sándor, Z. Assessment report on Urtica dioica L., Urtica urens L., their hybrids or their mixtures, radix. European Medicines Agency: London, United Kingdom, 2011, 1-38..
[10]
Blumenthal, M.; Busse, W.R.; Goldberg, A.; Gruenwald, J.; Hall, T.; Riggins, C.W.; Klein, S.; Rister, R.S. The complete German commission E monographs: Therapeutic guide to herbal medicines; American Botanical Council: Austin, TX, 1998.
[11]
Organization, W.H. WHO monographs on selected medicinal plants; World Health Organization, 1999, Vol. 2, .
[12]
Thorn, A. Monograph. Urtica dioica; Urtica urens (Nettle). Altern. Med. Rev., 2007, 12(3), 280-284.
[PMID: 18072824]
[13]
Lichius, J.J.; Muth, C. The inhibiting effects of Urtica dioica root extracts on experimentally induced prostatic hyperplasia in the mouse. Planta Med., 1997, 63(4), 307-310.
[http://dx.doi.org/10.1055/s-2006-957688 ] [PMID: 9270373]
[14]
Konrad, L.; Müller, H.H.; Lenz, C.; Laubinger, H.; Aumüller, G.; Lichius, J.J. Antiproliferative effect on human prostate cancer cells by a stinging nettle root (Urtica dioica) extract. Planta Med., 2000, 66(1), 44-47.
[http://dx.doi.org/10.1055/s-2000-11117 ] [PMID: 10705733]
[15]
Ziegler, H. Investigations of prostate cells under the effect of extract Radix Urticae (ERU) by fluorescent microscopy. Fortschr. Med., 1983, 101, 2112-2114.
[PMID: 6197352]
[16]
Nahata, A.; Dixit, V.K. Ameliorative effects of stinging nettle (Urtica dioica) on testosterone-induced prostatic hyperplasia in rats. Andrologia, 2012, 44(Suppl. 1), 396-409.
[http://dx.doi.org/10.1111/j.1439-0272.2011.01197.x ] [PMID: 21806658]
[17]
Morovvati, H.; Najafzadehvarzi, H.; Rashidi, K. Effect of Urtica dioica extract on histological and histometrical changes of testis of hamster after testosteron administration. Zahedan J. Res. Med. Sci., 2013, 15(11), 4-8.
[18]
Moradi, H.R.; Erfani Majd, N.; Esmaeilzadeh, S.; Fatemi Tabatabaei, S.R. The histological and histometrical effects of Urtica dioica extract on rat’s prostate hyperplasia. Vet. Res. Forum, 2015, 6(1), 23-29.
[PMID: 25992248]
[19]
Djulepa, J. Zweijährige erfahrung in der therapie des prosta-syndroms. Arztl. Prax., 1982, 34, 2199-2202.
[20]
Ziegler, H. Cytomorphologic studies of benign prostate hyperplasia treated with extract Radicis urticae (ERU). Preliminary results. Fortschr. Med., 1982, 100(39), 1832-1834.
[PMID: 6185399]
[21]
Oberholzer, M.; Schamböck, A.; Rugendorff, E.; Mihatsch, M.; Rist, M.; Buser, M. Elektronenmikroskopische Ergebnisse bei medikamentös behandelter benigner Prostatahyperplasie: Benigne Prostatahyperplasie; Zuckschwerdt: Munich, 1986.
[22]
Vontobel, H.; Herzog, R.; Rutishauser, G.; Kres, H. Ergebnis-se einer doppelblindstudie über die wirksamkeit von eru*-kapseln in der konservativen behandlung der benignen pros-tatahyperplasie. Urologe A, 1985, 24(1), 49-51.
[PMID: 2580383]
[23]
Dathe, G.; Schmid, H. Phytothérapie der Benignen Prostatahyperplasie (BPH) Doppelblindstudie mit Extraktum Radicis Urticae (ERU). Urologe B, 1987, 27(4), 223-226.
[24]
Maar, K. Rückbildung der Symptomatik von Prostataadeno-men. Fortschr. Med., 1987, 105, 50-52.
[25]
Romics, I. Observations with Bazoton in the management of prostatic hyperplasia. Int. Urol. Nephrol., 1987, 19(3), 293-297.
[http://dx.doi.org/10.1007/BF02549866 ] [PMID: 2444548]
[26]
Feiber, H. Sonographische Verlaufsbeobachtungen zum Ein-fluss der medikamentösen Therapie der benignen Prostatahy-perplasie (BPH).Benigne Prostatahyperplasie II, klinische und experimentelle Urologie 19; Bauer, H.W., Ed.; Zuckschwerdt: Munich, 1988.
[27]
Belaiche, P.; Lievoux, O. Clinical studies on the palliative treatment of prostatic adenoma with extract of Urtica root. Phytother. Res., 1991, 5, 267-269.
[http://dx.doi.org/10.1002/ptr.2650050608]
[28]
Fisher, M.; Wilbert, D. Wirkprüfung eines Phytopharmakons zur Behandlung der benignen Prostatahyperplasie (BPH).Benigne Prostatahyperplasie III, klinische und experi-mentelle Urologie 22; Rutishauser, G., Ed.; Zuckschwerdt: Munich, 1992, pp. 79-83.
[29]
Schneider, T.; Rübben, H. Stinging nettle root extract (Bazoton-uno) in long term treatment of benign prostatic syndrome (BPS). Results of a randomized, double-blind, placebo controlled multicenter study after 12 months. Urologe A, 2004, 43(3), 302-306.
[PMID: 15045190]
[30]
Safarinejad, M.R. Urtica dioica for treatment of benign prostatic hyperplasia: a prospective, randomized, double-blind, placebo-controlled, crossover study. J. Herb. Pharmacother., 2005, 5(4), 1-11.
[http://dx.doi.org/10.1080/J157v05n04_01 ] [PMID: 16635963]
[31]
Ghorbanibirgani, A.; Khalili, A.; Zamani, L. The efficacy of stinging nettle (Urtica dioica) in patients with benign prostatic hyperplasia: a randomized double-blind study in 100 patients. Iran. Red Crescent Med. J., 2013, 15(1), 9-10.
[http://dx.doi.org/10.5812/ircmj.2386 ] [PMID: 23487561]
[32]
Hosseinabadi, R.; Heidari, M.; Anbari, K.; Pournia, Y. Urtica dioica for treatment of lower urinary tract symptoms associated with benign prostatic hyperplasia. Int. J. Urol. Nurs., 2014, 8(3), 114-121.
[http://dx.doi.org/10.1111/ijun.12038]
[33]
Rhodes, L.; Primka, R.L.; Berman, C.; Vergult, G.; Gabriel, M.; Pierre-Malice, M.; Gibelin, B. Comparison of finasteride (Proscar), a 5 α reductase inhibitor, and various commercial plant extracts in in vitro and in vivo 5 α reductase inhibition. Prostate, 1993, 22(1), 43-51.
[http://dx.doi.org/10.1002/pros.2990220107 ] [PMID: 8381228]
[34]
Gansser, D.; Spiteller, G. Plant constituents interfering with human sex hormone-binding globulin. Evaluation of a test method and its application to Urtica dioica root extracts. Z. Natforsch. C J. Biosci., 1995, 50(1-2), 98-104.
[http://dx.doi.org/10.1515/znc-1995-1-215 ] [PMID: 7702715]
[35]
Schöttner, M.; Gansser, D.; Spiteller, G. Lignans from the roots of Urtica dioica and their metabolites bind to human Sex Hormone Binding Globulin (SHBG). Planta Med., 1997, 63(6), 529-532.
[http://dx.doi.org/10.1055/s-2006-957756 ] [PMID: 9434605]
[36]
Schmidt, K. Effect of Radix urticae extract and its several secondary extracts on blood SHBG in benign prostate hyperplasia. Fortschr. Med., 1983, 101(15), 713-716.
[PMID: 6189775]
[37]
Wagner, H.; Willer, F.; Kreher, B. Biologisch active verbindungen aus den wessere extrackt von Urtica dioica. Planta Med., 1989, 55, 452-454.
[http://dx.doi.org/10.1055/s-2006-962062 ] [PMID: 2813580]
[38]
Hryb, D.J.; Khan, M.S.; Romas, N.A.; Rosner, W. The effect of extracts of the roots of the stinging nettle (Urtica dioica) on the interaction of SHBG with its receptor on human prostatic membranes. Planta Med., 1995, 61(1), 31-32.
[http://dx.doi.org/10.1055/s-2006-957993 ] [PMID: 7700987]
[39]
Gansser, D.; Spiteller, G. Aromatase inhibitors from Urtica dioica roots. Planta Med., 1995, 61(2), 138-140.
[http://dx.doi.org/10.1055/s-2006-958033 ] [PMID: 17238068]
[40]
Hajhashemi, V.; Klooshani, V. Antinociceptive and anti-inflammatory effects of Urtica dioica leaf extract in animal models. Avicenna J. Phytomed., 2013, 3(2), 193-200.
[PMID: 25050274]
[41]
Johnson, T.A.; Sohn, J.; Inman, W.D.; Bjeldanes, L.F.; Rayburn, K. Lipophilic stinging nettle extracts possess potent anti-inflammatory activity, are not cytotoxic and may be superior to traditional tinctures for treating inflammatory disorders. Phytomedicine, 2013, 20(2), 143-147.
[http://dx.doi.org/10.1016/j.phymed.2012.09.016 ] [PMID: 23092723]
[42]
Francišković, M.; Gonzalez-Pérez, R.; Orčić, D.; Sánchez de Medina, F.; Martínez-Augustin, O.; Svirčev, E.; Simin, N.; Mimica-Dukić, N. Chemical composition and immuno-modulatory effects of Urtica dioica L. (stinging nettle) extracts. Phytother. Res., 2017, 31(8), 1183-1191.
[http://dx.doi.org/10.1002/ptr.5836 ] [PMID: 28544187]
[43]
Durak, I.; Biri, H.; Devrim, E.; Sözen, S.; Avci, A. Aqueous extract of Urtica dioica makes significant inhibition on adenosine deaminase activity in prostate tissue from patients with prostate cancer. Cancer Biol. Ther., 2004, 3(9), 855-857.
[http://dx.doi.org/10.4161/cbt.3.9.1038 ] [PMID: 15254411]
[44]
Wagner, H.; Willer, F.; Samtleben, R.; Boos, G. Search for the antiprostatic principle of stinging nettle (Urtica dioica) roots. Phytomedicine, 1994, 1(3), 213-224.
[http://dx.doi.org/10.1016/S0944-7113(11)80068-1 ] [PMID: 23195942]
[45]
Chrubasik, J.E.; Roufogalis, B.D.; Wagner, H.; Chrubasik, S. A comprehensive review on the stinging nettle effect and efficacy profiles. Part II: urticae radix. Phytomedicine, 2007, 14(7-8), 568-579.
[http://dx.doi.org/10.1016/j.phymed.2007.03.014 ] [PMID: 17509841]
[46]
Edwards, S.E.; da Costa Rocha, I.; Heinrich, M.; Williamson, E.M. Phytopharmacy: an evidence-based guide to herbal medicinal products; John Wiley & Sons: New York, 2015.
[http://dx.doi.org/10.1002/9781118543436]
[47]
Bombardelli, E.; Morazzoni, P. Urtica dioica L. Fitoterapia, 1997, 68, 387-402.

Rights & Permissions Print Cite
Article Metrics
14
© 2024 Bentham Science Publishers | Privacy Policy