Login Register Cart 0
Generic placeholder image

Current Pharmaceutical Design

Editor-in-Chief

ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Back
Journal Home About Journal Editorial Board Journal Insight Current Issue Volumes/Issues
Subscribe
Review Article

Polyphenol-Rich Foods and Osteoporosis

Author(s): Emanuele Chisari*, Nitin Shivappa and Shraddha Vyas

Volume 25, Issue 22, 2019

Page: [2459 - 2466] Pages: 8

DOI: 10.2174/1381612825666190722093959

Price: $65

Abstract

Background: Osteoporosis is a metabolic disease affecting the bone mineral density and thus compromise the strength of the bones. Disease prevention through diet is the objective of the study and discussion. Among the several nutrients investigated, the intake of phenols seems to influence bone mineral density by acting as free radical scavengers, preventing oxidation-induced damage to bone cells. In addition, the growing understanding of the bone remodelling process supports the theory that inflammation significantly contributes to the etiopathogenesis of osteoporosis.

Methods: To provide an overview of current evidence on polyphenol-rich foods and osteoporosis prevention we made a comprehensive review of the literature focusing on the state of art of the topic.

Results: Some polyphenol-rich foods, including olive oil, fruit and vegetable, tea and soy, seem to be beneficial for preventing osteoporosis disease and its progression. The mechanism is still partly unknown and may involve different pathways which include inflammation and other disease reactions.

Conclusions: However, further research is needed to better understand the mechanisms regulating the molecular interaction between osteoporosis incidence and progression and polyphenol-rich foods. The current evidence suggests that dietary intervention with polyphenol rich foods may be useful to prevent incidence and progression of this condition.

Keywords: Polyphenols, osteoporosis, antioxidants, food, diet, natural antioxidants.

« Previous Next »
[1]
GBD 2017 DALYs and HALE collaborators. Global, regional, and national disability-adjusted life-years (DALYs) for 359 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet 2018; 392(10159): 1859-922.
[http://dx.doi.org/10.1016/S0140-6736(18)32335-3] [PMID: 30415748]
[2]
Assessment of fracture risk and its application to screening for postmenopausal osteoporosis. Report of a WHO Study Group. World Health Organ Tech Rep Ser 1994; 843: 1-129.
[PMID: 7941614]
[3]
Curtis EM, Moon RJ, Harvey NC, Cooper C. The impact of fragility fracture and approaches to osteoporosis risk assessment worldwide. Bone 2017; 104: 29-38.
[http://dx.doi.org/10.1016/j.bone.2017.01.024] [PMID: 28119181]
[4]
NIH consensus development panel on osteoprosis prevention, diagnosis and therapy. Osteoporosis prevention, diagnosis, and therapy. JAMA 2001; 285(6): 785-95.
[http://dx.doi.org/10.1001/jama.285.6.785] [PMID: 11176917]
[5]
Rivas A, Romero A, Mariscal-Arcas M, et al. Association between dietary antioxidant quality score (DAQs) and bone mineral density in Spanish women. Nutr Hosp 2012; 27(6): 1886-93.
[PMID: 23588435]
[6]
Cauley JA, Danielson ME, Boudreau RM, et al. Inflammatory markers and incident fracture risk in older men and women: the Health Aging and Body Composition Study. J Bone Miner Res 2007; 22(7): 1088-95.
[http://dx.doi.org/10.1359/jbmr.070409] [PMID: 17419681]
[7]
Onvani S, Haghighatdoost F, Surkan PJ, Larijani B, Azadbakht L. Adherence to the Healthy Eating Index and Alternative Healthy Eating Index dietary patterns and mortality from all causes, cardiovascular disease and cancer: a meta-analysis of observational studies. J Hum Nutr Diet 2017; 30(2): 216-26.
[http://dx.doi.org/10.1111/jhn.12415] [PMID: 27620213]
[8]
Grosso G, Bella F, Godos J, et al. Possible role of diet in cancer: systematic review and multiple meta-analyses of dietary patterns, lifestyle factors, and cancer risk. Nutr Rev 2017; 75(6): 405-19.
[http://dx.doi.org/10.1093/nutrit/nux012] [PMID: 28969358]
[9]
Denova-Gutiérrez E, Méndez-Sánchez L, Muñoz-Aguirre P, Tucker KL, Clark P. Dietary Patterns, Bone Mineral Density, and Risk of Fractures: A Systematic Review and Meta-Analysis. Nutrients 2018; 10(12): 1922.
[http://dx.doi.org/10.3390/nu10121922] [PMID: 30563066]
[10]
Levis S, Lagari VS. The role of diet in osteoporosis prevention and management. Curr Osteoporos Rep 2012; 10(4): 296-302.
[http://dx.doi.org/10.1007/s11914-012-0119-y] [PMID: 23001895]
[11]
Castro-Barquero S, Lamuela-Raventós RM, Doménech M, Estruch R. Relationship between mediterranean dietary polyphenol intake and obesity. Nutrients 2018; 10(10): 1523-7.
[12]
Rienks J, Barbaresko J, Nöthlings U. Association of polyphenol biomarkers with cardiovascular disease and mortality risk: A systematic review and Meta-Analysis of observational studies. Nutrients 2017; 9(4): 415-22.
[13]
Grosso G, Micek A, Godos J, et al. Dietary flavonoid and lignan intake and mortality in prospective cohort studies: Systematic review and dose-response meta-analysis. Am J Epidemiol 2017; 185(12): 1304-16.
[http://dx.doi.org/10.1093/aje/kww207] [PMID: 28472215]
[14]
Grosso G, Godos J, Lamuela-Raventos R, et al. A comprehensive meta-analysis on dietary flavonoid and lignan intake and cancer risk: Level of evidence and limitations. Mol Nutr Food Res 2017; 61(4)1600930
[http://dx.doi.org/10.1002/mnfr.201600930] [PMID: 27943649]
[15]
Tomás-Barberán FA, Selma MV, Espín JC. Interactions of gut microbiota with dietary polyphenols and consequences to human health. Curr Opin Clin Nutr Metabol Care 2016; 19(6): 471-6.
[http://dx.doi.org/10.1097/MCO.0000000000000314]
[16]
Santino A, Scarano A, De Santis S, De Benedictis M, Giovinazzo G, Chieppa M. Gut microbiota modulation and anti-inflammatory properties of dietary polyphenols in IBD: New and consolidated perspectives. Curr Pharm Des 2017; 23(16): 2344-51.
[http://dx.doi.org/10.2174/1381612823666170207145420] [PMID: 28176667]
[17]
Grosso G, Stepaniak U, Micek A, Stefler D, Bobak M, Pająk A. Dietary polyphenols are inversely associated with metabolic syndrome in Polish adults of the HAPIEE study. Eur J Nutr 2017; 56(4): 1409-20.
[http://dx.doi.org/10.1007/s00394-016-1187-z] [PMID: 26913852]
[18]
Carnauba RA, Chaves DFS, Baptistella AB, Paschoal V, Naves A, Buehler AM. Association between high consumption of phytochemical-rich foods and anthropometric measures: a systematic review. Int J Food Sci Nutr 2017; 68(2): 158-66.
[http://dx.doi.org/10.1080/09637486.2016.1229761] [PMID: 27608733]
[19]
Amiot MJ, Riva C, Vinet A. Effects of dietary polyphenols on metabolic syndrome features in humans: a systematic review. Obes Rev 2016; 17(7): 573-86.
[http://dx.doi.org/10.1111/obr.12409] [PMID: 27079631]
[20]
Grosso G, Estruch R. Nut consumption and age-related disease. Maturitas 2016; 84: 11-6.
[http://dx.doi.org/10.1016/j.maturitas.2015.10.014]
[21]
Hernández Morante JJ, Gómez Martínez C, Morillas-Ruiz JM. Dietary factors associated with frailty in old adults: A review of nutritional interventions to prevent frailty development. Nutrients 2019; 11(1): 102.
[http://dx.doi.org/10.3390/nu11010102] [PMID: 30621313]
[22]
Grosso G, Stepaniak U, Topor-Mądry R, Szafraniec K, Pająk A. Estimated dietary intake and major food sources of polyphenols in the Polish arm of the HAPIEE study. Nutrition 2014; 30(11-12): 1398-403.
[http://dx.doi.org/10.1016/j.nut.2014.04.012] [PMID: 25280419]
[23]
Pérez-Jiménez J, Fezeu L, Touvier M, et al. Dietary intake of 337 polyphenols in French adults. Am J Clin Nutr 2011; 93(6): 1220-8.
[http://dx.doi.org/10.3945/ajcn.110.007096] [PMID: 21490142]
[24]
Tresserra-Rimbau A, Medina-Remón A, Pérez-Jiménez J, et al. Dietary intake and major food sources of polyphenols in a Spanish population at high cardiovascular risk: the PREDIMED study. Nutr Metab Cardiovasc Dis 2013; 23(10): 953-9.
[http://dx.doi.org/10.1016/j.numecd.2012.10.008] [PMID: 23332727]
[25]
Nascimento-Souza MA, de Paiva PG, Pérez-Jiménez J, do Carmo Castro Franceschini S, Ribeiro AQ. Estimated dietary intake and major food sources of polyphenols in elderly of Viçosa, Brazil: a population-based study. Eur J Nutr 2018; 57(2): 617-27.
[http://dx.doi.org/10.1007/s00394-016-1348-0] [PMID: 27873069]
[26]
Godos J, Marventano S, Mistretta A, Galvano F, Grosso G. Dietary sources of polyphenols in the Mediterranean healthy Eating, Aging and Lifestyle (MEAL) study cohort. Int J Food Sci Nutr 2017; 68(6): 750-6.
[http://dx.doi.org/10.1080/09637486.2017.1285870] [PMID: 28276907]
[27]
Taguchi C, Fukushima Y, Kishimoto Y, et al. Estimated dietary polyphenol intake and major food and beverage sources among elderly japanese. Nutrients 2015; 7(12): 10269-81.
[http://dx.doi.org/10.3390/nu7125530] [PMID: 26690212]
[28]
Godos J, Pluchinotta FR, Marventano S, et al. Coffee components and cardiovascular risk: Beneficial and detrimental effects. Int J Food Sci Nutr 2014; 65(8): 925-36.
[http://dx.doi.org/10.3109/09637486.2014.940287]
[29]
Zhang Y, Zhang D-Z. Is coffee consumption associated with a lower level of serum C-reactive protein? A meta-analysis of observational studies. Int J Food Sci Nutr 2018; 69(8): 985-94.
[http://dx.doi.org/10.1080/09637486.2018.1433640] [PMID: 29405789]
[30]
Zhang Y, Zhang DZ. Associations of coffee consumption with circulating level of adiponectin and leptin. A meta-analysis of observational studies. Int J Food Sci Nutr 2018; 69(8): 1003-12.
[http://dx.doi.org/10.1080/09637486.2018.1445202] [PMID: 29513118]
[31]
Marventano S, Salomone F, Godos J, et al. Coffee and tea consumption in relation with non-alcoholic fatty liver and metabolic syndrome: A systematic review and meta-analysis of observational studies. Clin Nutr 2016; 35(6): 1269-81.
[http://dx.doi.org/10.1016/j.clnu.2016.03.012] [PMID: 27060021]
[32]
Kiel DP, Felson DT, Hannan MT, Anderson JJ, Wilson PWF. Caffeine and the risk of hip fracture: the Framingham Study. Am J Epidemiol 1990; 132(4): 675-84.
[http://dx.doi.org/10.1093/oxfordjournals.aje.a115709] [PMID: 2403108]
[33]
Hallström H, Melhus H, Glynn A, Lind L, Syvänen AC, Michaëlsson K. Coffee consumption and CYP1A2 genotype in relation to bone mineral density of the proximal femur in elderly men and women: a cohort study. Nutr Metab (Lond) 2010; 7(1): 12.
[http://dx.doi.org/10.1186/1743-7075-7-12] [PMID: 20175915]
[34]
Suzuki T, Yoshida H, Hashimoto T, et al. Case-control study of risk factors for hip fractures in the Japanese elderly by a Mediterranean Osteoporosis Study (MEDOS) questionnaire. Bone 1997; 21(5): 461-7.
[http://dx.doi.org/10.1016/S8756-3282(97)00179-8] [PMID: 9356741]
[35]
Hernandez-Avila M, Colditz GA, Stampfer MJ, Rosner B, Speizer FE, Willett WC. Caffeine, moderate alcohol intake, and risk of fractures of the hip and forearm in middle-aged women. Am J Clin Nutr 1991; 54(1): 157-63.
[http://dx.doi.org/10.1093/ajcn/54.1.157] [PMID: 2058578]
[36]
Lee DR, Lee J, Rota M, et al. Coffee consumption and risk of fractures: a systematic review and dose-response meta-analysis. Bone 2014; 63: 20-8.
[http://dx.doi.org/10.1016/j.bone.2014.02.007] [PMID: 24576685]
[37]
Forsmo S, Schei B, Langhammer A, Forsén L. How do reproductive and lifestyle factors influence bone density in distal and ultradistal radius of early postmenopausal women? The Nord-Trøndelag Health Survey, Norway. Osteoporos Int 2001; 12(3): 222-9.
[http://dx.doi.org/10.1007/s001980170133] [PMID: 11315241]
[38]
Meyer HE, Pedersen JI, Løken EB, Tverdal A. Dietary factors and the incidence of hip fracture in middle-aged Norwegians. A prospective study. Am J Epidemiol 1997; 145(2): 117-23.
[http://dx.doi.org/10.1093/oxfordjournals.aje.a009082] [PMID: 9006308]
[39]
Demirbag D, Ozdemir F, Ture M. Effects of coffee consumption and smoking habit on bone mineral density. Rheumatol Int 2006; 26(6): 530-5.
[http://dx.doi.org/10.1007/s00296-005-0020-4] [PMID: 16025331]
[40]
Hamdi Kara I, Aydin S, Gemalmaz A, et al. Habitual tea drinking and bone mineral density in postmenopausal Turkish women: investigation of prevalence of postmenopausal osteoporosis in Turkey (IPPOT Study). Int J Vitam Nutr Res 2007; 77(6): 389-97.
[http://dx.doi.org/10.1024/0300-9831.77.6.389] [PMID: 18622949]
[41]
Choi E, Choi KH, Park SM, Shin D, Joh HK, Cho E. The benefit of bone health by drinking coffee among Korean postmenopausal women: A cross-sectional analysis of the fourth & fifth Korea National Health and Nutrition Examination Surveys. PLoS One 2016; 11(1)e0147762
[http://dx.doi.org/10.1371/journal.pone.0147762] [PMID: 26816211]
[42]
Su SJ, Chang KL, Su SH, Yeh YT, Shyu HW, Chen KM. Caffeine regulates osteogenic differentiation and mineralization of primary adipose-derived stem cells and a bone marrow stromal cell line. Int J Food Sci Nutr 2013; 64(4): 429-36.
[http://dx.doi.org/10.3109/09637486.2012.759184] [PMID: 23301724]
[43]
Hasling C, Søndergaard K, Charles P, Mosekilde L. Calcium metabolism in postmenopausal osteoporotic women is determined by dietary calcium and coffee intake. J Nutr 1992; 122(5): 1119-26.
[http://dx.doi.org/10.1093/jn/122.5.1119] [PMID: 1564564]
[44]
Schubert MM, Irwin C, Seay RF, Clarke HE, Allegro D, Desbrow B. Caffeine, coffee, and appetite control: a review. Int J Food Sci Nutr 2017; 68(8): 901-12.
[http://dx.doi.org/10.1080/09637486.2017.1320537] [PMID: 28446037]
[45]
Bai XC, Lu D, Bai J, et al. Oxidative stress inhibits osteoblastic differentiation of bone cells by ERK and NF-kappaB. Biochem Biophys Res Commun 2004; 314(1): 197-207.
[http://dx.doi.org/10.1016/j.bbrc.2003.12.073] [PMID: 14715266]
[46]
Kamiyama M, Moon JK, Jang HW, Shibamoto T. Role of degradation products of chlorogenic acid in the antioxidant activity of roasted coffee. J Agric Food Chem 2015; 63(7): 1996-2005.
[http://dx.doi.org/10.1021/jf5060563] [PMID: 25658375]
[47]
Zhou RP, Lin SJ, Wan WB, et al. Chlorogenic acid prevents osteoporosis by Shp2/PI3K/Akt pathway in ovariectomized rats. PLoS One 2016; 11(12)e0166751
[http://dx.doi.org/10.1371/journal.pone.0166751] [PMID: 28033335]
[48]
Min J, Yuan Z, Zhang Q, Lin S, Wang K, Luo J. Analysis of anti-osteoporosis function of chlorogenic acid by gene microarray profiling in ovariectomy rat model. Biosci Rep 2018; 38(4)BSR20180775
[http://dx.doi.org/10.1042/BSR20180775] [PMID: 30054432]
[49]
Han D, Chen W, Gu X, et al. Cytoprotective effect of chlorogenic acid against hydrogen peroxide-induced oxidative stress in MC3T3-E1 cells through PI3K/Akt-mediated Nrf2/HO-1 signaling pathway. Oncotarget 2017; 8(9): 14680-92.
[http://dx.doi.org/10.18632/oncotarget.14747] [PMID: 28122344]
[50]
Grosso G, Godos J, Galvano F, Giovannucci EL. Coffee, Caffeine, and Health Outcomes: An Umbrella Review. Annu Rev Nutr 2017; 37(1): 131-56.
[http://dx.doi.org/10.1146/annurev-nutr-071816-064941] [PMID: 28826374]
[51]
Dinu M, Pagliai G, Casini A, Sofi F. Mediterranean diet and multiple health outcomes: An umbrella review of meta-analyses of observational studies and randomised trials. Eur J Clin Nutr 2018; 72(1): 30-43.
[http://dx.doi.org/10.1038/ejcn.2017.58]
[52]
García-Martínez O, Rivas A, Ramos-Torrecillas J, De Luna-Bertos E, Ruiz C. The effect of olive oil on osteoporosis prevention. Int J Food Sci Nutr 2014; 65(7): 834-40.
[http://dx.doi.org/10.3109/09637486.2014.931361] [PMID: 24975408]
[53]
Fernández-Real JM, Bulló M, Moreno-Navarrete JM, et al. A Mediterranean diet enriched with olive oil is associated with higher serum total osteocalcin levels in elderly men at high cardiovascular risk. J Clin Endocrinol Metab 2012; 97(10): 3792-8.
[http://dx.doi.org/10.1210/jc.2012-2221] [PMID: 22855341]
[54]
Martínez-Ramírez MJ, Palma S, Martínez-González MA, Delgado-Martínez AD, de la Fuente C, Delgado-Rodríguez M. Dietary fat intake and the risk of osteoporotic fractures in the elderly. Eur J Clin Nutr 2007; 61(9): 1114-20.
[http://dx.doi.org/10.1038/sj.ejcn.1602624] [PMID: 17299494]
[55]
Trichopoulou A, Georgiou E, Bassiakos Y, et al. Energy intake and monounsaturated fat in relation to bone mineral density among women and men in Greece. Prev Med 1997; 26(3): 395-400.
[http://dx.doi.org/10.1006/pmed.1997.0160] [PMID: 9144765]
[56]
Kontogianni MD, Melistas L, Yannakoulia M, Malagaris I, Panagiotakos DB, Yiannakouris N. Association between dietary patterns and indices of bone mass in a sample of Mediterranean women. Nutrition 2009; 25(2): 165-71.
[http://dx.doi.org/10.1016/j.nut.2008.07.019] [PMID: 18849146]
[57]
Puel C, Quintin A, Agalias A, et al. Olive oil and its main phenolic micronutrient (oleuropein) prevent inflammation-induced bone loss in the ovariectomised rat. Br J Nutr 2004; 92(1): 119-27.
[http://dx.doi.org/10.1079/BJN20041181] [PMID: 15230995]
[58]
Saleh NK, Saleh HA. Olive oil effectively mitigates ovariectomy-induced osteoporosis in rats. BMC Complement Altern Med 2011; 11(1): 10.
[http://dx.doi.org/10.1186/1472-6882-11-10] [PMID: 21294895]
[59]
Liu H, Huang H, Li B, et al. Olive oil in the prevention and treatment of osteoporosis after artificial menopause. Clin Interv Aging 2014; 9: 2087-95.
[http://dx.doi.org/10.2147/CIA.S72006] [PMID: 25506212]
[60]
Puel C, Mardon J, Agalias A, et al. Major phenolic compounds in olive oil modulate bone loss in an ovariectomy/inflammation experimental model. J Agric Food Chem 2008; 56(20): 9417-22.
[http://dx.doi.org/10.1021/jf801794q] [PMID: 18800805]
[61]
Paiva-Martins F, Rodrigues V, Calheiros R, Marques MP. Characterization of antioxidant olive oil biophenols by spectroscopic methods. J Sci Food Agric 2011; 91(2): 309-14.
[http://dx.doi.org/10.1002/jsfa.4186] [PMID: 20949551]
[62]
Covas MI. Bioactive effects of olive oil phenolic compounds in humans: Reduction of heart disease factors and oxidative damage. Inflammopharmacology 16(5): 216-8.
[http://dx.doi.org/10.1007/s10787-008-8019-6]
[63]
Cicerale S, Conlan XA, Barnett NW, Keast RSJ. Storage of extra virgin olive oil and its effect on the biological activity and concentration of oleocanthal. Food Res Int 2013; 50(2): 597-602.
[http://dx.doi.org/10.1016/j.foodres.2011.03.046]
[64]
Cicerale S, Lucas LJ, Keast RSJ. Antimicrobial, antioxidant and anti-inflammatory phenolic activities in extra virgin olive oil. Curr Opin Biotechnol 2012; 23(2): 129-35.
[http://dx.doi.org/10.1016/j.copbio.2011.09.006]
[65]
Chin KY, Pang KL. Therapeutic effects of olive and its derivatives on osteoarthritis: From bench to bedside. Nutrients 2012; 9(10): 1060-26.
[http://dx.doi.org/10.3390/nu9101060]
[66]
Hagiwara K, Goto T, Araki M, Miyazaki H, Hagiwara H. Olive polyphenol hydroxytyrosol prevents bone loss. Eur J Pharmacol 2011; 662(1-3): 78-84.
[http://dx.doi.org/10.1016/j.ejphar.2011.04.023] [PMID: 21539839]
[67]
García-Martínez O, De Luna-Bertos E, Ramos-Torrecillas J, et al. Phenolic compounds in extra virgin olive oil stimulate human osteoblastic cell proliferation. PLoS One 2016; 11(3)e0150045
[http://dx.doi.org/10.1371/journal.pone.0150045] [PMID: 26930190]
[68]
Kim TH, Jung JW, Ha BG, et al. The effects of luteolin on osteoclast differentiation, function in vitro and ovariectomy-induced bone loss. J Nutr Biochem 2011; 22(1): 8-15.
[http://dx.doi.org/10.1016/j.jnutbio.2009.11.002] [PMID: 20233653]
[69]
Santiago-Mora R, Casado-Díaz A, De Castro MD, Quesada-Gómez JM. Oleuropein enhances osteoblastogenesis and inhibits adipogenesis: the effect on differentiation in stem cells derived from bone marrow. Osteoporos Int 2011; 22(2): 675-84.
[http://dx.doi.org/10.1007/s00198-010-1270-x] [PMID: 20495905]
[70]
Khan N, Mukhtar H. Tea Polyphenols in Promotion of Human Health. Nutrients 2018; 11(1): 39.
[http://dx.doi.org/10.3390/nu11010039] [PMID: 30585192]
[71]
Shen C-L, Yeh JK, Cao JJ, Chyu M-C, Wang J-S. Green tea and bone health: Evidence from laboratory studies. Pharmacol Res 2011; 64(2): 155-61.
[http://dx.doi.org/10.1016/j.phrs.2011.03.012] [PMID: 21473914]
[72]
Shen CL, Chyu MC. Tea flavonoids for bone health: from animals to humans. J Investig Med 2016; 64(7): 1151-7.
[http://dx.doi.org/10.1136/jim-2016-000190] [PMID: 27356546]
[73]
Guo M, Qu H, Xu L, Shi DZ. Tea consumption may decrease the risk of osteoporosis: an updated meta-analysis of observational studies. Nutr Res 2017; 42: 1-10.
[http://dx.doi.org/10.1016/j.nutres.2017.02.010] [PMID: 28633866]
[74]
Dostal AM, Arikawa A, Espejo L, Kurzer MS. Long-term supplementation of green tea extract does not modify adiposity or bone mineral density in a randomized trial of overweight and obese postmenopausal women. J Nutr 2016; 146(2): 256-64.
[http://dx.doi.org/10.3945/jn.115.219238] [PMID: 26701796]
[75]
Shen CL, Chyu MC, Yeh JK, et al. Effect of green tea and Tai Chi on bone health in postmenopausal osteopenic women: a 6-month randomized placebo-controlled trial. Osteoporos Int 2012; 23(5): 1541-52.
[http://dx.doi.org/10.1007/s00198-011-1731-x] [PMID: 21766228]
[76]
Qian G, Xue K, Tang L, et al. Mitigation of oxidative damage by green tea polyphenols and Tai Chi exercise in postmenopausal women with osteopenia. PLoS One 2012; 7(10)e48090
[http://dx.doi.org/10.1371/journal.pone.0048090] [PMID: 23118932]
[77]
Conlisk AJ, Galuska DA. Is caffeine associated with bone mineral density in young adult women? Prev Med 2000; 31(5): 562-8.
[http://dx.doi.org/10.1006/pmed.2000.0742] [PMID: 11071837]
[78]
Shen C-L, Wang P, Guerrieri J, Yeh JK, Wang J-S. Protective effect of green tea polyphenols on bone loss in middle-aged female rats. Osteoporos Int 2008; 19(7): 979-90.
[http://dx.doi.org/10.1007/s00198-007-0527-5] [PMID: 18084689]
[79]
Iwaniec UT, Turner RT, Koo SI, et al. Consumption of green tea extract results in osteopenia in growing male mice. J Nutr 2009; 139(10): 1914-9.
[http://dx.doi.org/10.3945/jn.109.107201] [PMID: 19710162]
[80]
Shen C-L, Cao JJ, Dagda RY, et al. Green tea polyphenols benefits body composition and improves bone quality in long-term high-fat diet-induced obese rats. Nutr Res 2012; 32(6): 448-57.
[http://dx.doi.org/10.1016/j.nutres.2012.05.001] [PMID: 22749181]
[81]
Shen CL, Chyu MC, Wang JS. Tea and bone health: steps forward in translational nutrition. Am J Clin Nutr 2013; 98(6)(Suppl.): 1694S-9S.
[http://dx.doi.org/10.3945/ajcn.113.058255] [PMID: 24172296]
[82]
Shen C-L, Yeh JK, Samathanam C, et al. Green tea polyphenols attenuate deterioration of bone microarchitecture in female rats with systemic chronic inflammation. Osteoporos Int 2011; 22(1): 327-37.
[http://dx.doi.org/10.1007/s00198-010-1209-2] [PMID: 20306019]
[83]
Jin P, Wu H, Xu G, Zheng L, Zhao J. Epigallocatechin-3-gallate (EGCG) as a pro-osteogenic agent to enhance osteogenic differentiation of mesenchymal stem cells from human bone marrow: an in vitro study. Cell Tissue Res 2014; 356(2): 381-90.
[http://dx.doi.org/10.1007/s00441-014-1797-9] [PMID: 24682582]
[84]
Tominari T, Matsumoto C, Watanabe K, et al. Epigallocatechin gallate (EGCG) suppresses lipopolysaccharide-induced inflammatory bone resorption, and protects against alveolar bone loss in mice. FEBS Open Bio 2015; 5(1): 522-7.
[http://dx.doi.org/10.1016/j.fob.2015.06.003] [PMID: 26155460]
[85]
Liu S, Yang L, Mu S, Fu Q. Epigallocatechin-3-gallate ameliorates glucocorticoid-induced osteoporosis of rats in vivo and in vitro. Front Pharmacol 2018; 9(5): 447.
[http://dx.doi.org/10.3389/fphar.2018.00447] [PMID: 29867459]
[86]
Chen S-T, Kang L, Wang CZ, et al. (-)-Epigallocatechin-3-Gallate Decreases Osteoclastogenesis via Modulation of RANKL and Osteoprotegrin. Molecules 2019; 24(1): 156.
[http://dx.doi.org/10.3390/molecules24010156] [PMID: 30609798]
[87]
Hsiao HB, Wu JB, Lin WC. (-)-Epicatechin 3-O-β-D-allopyranoside prevent ovariectomy-induced bone loss in mice by suppressing RANKL-induced NF-κB and NFATc-1 signaling pathways. BMC Complement Altern Med 2017; 17(1): 245.
[http://dx.doi.org/10.1186/s12906-017-1737-9] [PMID: 28468652]
[88]
Tinker LF, Schneeman BO, Davis PA, Gallaher DD, Waggoner CR. Consumption of prunes as a source of dietary fiber in men with mild hypercholesterolemia. Am J Clin Nutr 1991; 53(5): 1259-65.
[http://dx.doi.org/10.1093/ajcn/53.5.1259] [PMID: 1850578]
[89]
Angelino D, Godos J, Ghelfi F, et al. Fruit and vegetable consumption and health outcomes: an umbrella review of observational studies. Int J Food Sci Nutr 2019; 70(6): 652-67.
[http://dx.doi.org/10.1080/09637486.2019.1571021] [PMID: 30764679]
[90]
Hu D, Cheng L, Jiang W. Fruit and vegetable consumption and the risk of postmenopausal osteoporosis: a meta-analysis of observational studies. Food Funct 2018; 9(5): 2607-16.
[http://dx.doi.org/10.1039/C8FO00205C] [PMID: 29744503]
[91]
Trzeciakiewicz A, Habauzit V, Horcajada MN. When nutrition interacts with osteoblast function: Molecular mechanisms of polyphenols. Nutr Res Rev 2009; 22(1): 68-81.
[http://dx.doi.org/10.1017/S095442240926402X]
[92]
Süntar I, Akkol EK. Beneficial effects of plant sources on the treatment of osteoporosis. Curr Drug Targets 2013; 14(13): 1611-8.
[http://dx.doi.org/10.2174/13894501113149990205] [PMID: 23978060]
[93]
New SA, Robins SP, Campbell MK, et al. Dietary influences on bone mass and bone metabolism: further evidence of a positive link between fruit and vegetable consumption and bone health? Am J Clin Nutr 2000; 71(1): 142-51.
[http://dx.doi.org/10.1093/ajcn/71.1.142] [PMID: 10617959]
[94]
Chen YM, Ho SC, Woo JLF. Greater fruit and vegetable intake is associated with increased bone mass among postmenopausal Chinese women. Br J Nutr 2006; 96(4): 745-51.
[PMID: 17010235]
[95]
Langsetmo L, Hanley DA, Prior JC, et al. Dietary patterns and incident low-trauma fractures in postmenopausal women and men aged ≥ 50 y: a population-based cohort study. Am J Clin Nutr 2011; 93(1): 192-9.
[http://dx.doi.org/10.3945/ajcn.110.002956] [PMID: 21068350]
[96]
McTiernan A, Wactawski-Wende J, Wu L, et al. Low-fat, increased fruit, vegetable, and grain dietary pattern, fractures, and bone mineral density: the Women’s Health Initiative Dietary Modification Trial. Am J Clin Nutr 2009; 89(6): 1864-76.
[http://dx.doi.org/10.3945/ajcn.2008.26956] [PMID: 19403636]
[97]
Buclin T, Cosma M, Appenzeller M, et al. Diet acids and alkalis influence calcium retention in bone. Osteoporos Int 2001; 12(6): 493-9.
[http://dx.doi.org/10.1007/s001980170095] [PMID: 11446566]
[98]
Teucher B, Fairweather-Tait S. Dietary sodium as a risk factor for osteoporosis: where is the evidence? Proc Nutr Soc 2003; 62(4): 859-66.
[PMID: 15018486]
[99]
Lanham-New SA. Fruit and vegetables: the unexpected natural answer to the question of osteoporosis prevention? Am J Clin Nutr 2006; 83(6): 1254-5.
[http://dx.doi.org/10.1093/ajcn/83.6.1254] [PMID: 16762933]
[100]
Tucker KL. Osteoporosis prevention and nutrition. Curr Osteopor Rep 2009; 7(4): 111-7.
[http://dx.doi.org/10.1007/s11914-009-0020-5]
[101]
Welch A, MacGregor A, Jennings A, Fairweather-Tait S, Spector T, Cassidy A. Habitual flavonoid intakes are positively associated with bone mineral density in women. J Bone Miner Res 2012; 27(9): 1872-8.
[http://dx.doi.org/10.1002/jbmr.1649] [PMID: 22549983]
[102]
Hooshmand S, Chai SC, Saadat RL, Payton ME, Brummel-Smith K, Arjmandi BH. Comparative effects of dried plum and dried apple on bone in postmenopausal women. Br J Nutr 2011; 106(6): 923-30.
[http://dx.doi.org/10.1017/S000711451100119X] [PMID: 21736808]
[103]
Arjmandi BH, Khalil DA, Lucas EA, et al. Dried plums improve indices of bone formation in postmenopausal women. J Womens Health Gend Based Med 2002; 11(1): 61-8.
[http://dx.doi.org/10.1089/152460902753473471] [PMID: 11860726]
[104]
Messina M. Soy and health update: Evaluation of the clinical and epidemiologic literature. Nutrients 2016; 8(12): piiE754.
[http://dx.doi.org/10.3390/nu8120754]
[105]
Rutherfurd SM, Fanning AC, Miller BJ, Moughan PJ. Protein digestibility-corrected amino acid scores and digestible indispensable amino acid scores differentially describe protein quality in growing male rats. J Nutr 2015; 145(2): 372-9.
[http://dx.doi.org/10.3945/jn.114.195438] [PMID: 25644361]
[106]
Hughes GJ, Ryan DJ, Mukherjea R, Schasteen CS. Protein digestibility-corrected amino acid scores (PDCAAS) for soy protein isolates and concentrate: criteria for evaluation. J Agric Food Chem 2011; 59(23): 12707-12.
[http://dx.doi.org/10.1021/jf203220v] [PMID: 22017752]
[107]
Kuiper GGJM, Lemmen JG, Carlsson B, et al. Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor β. Endocrinology 1998; 139(10): 4252-63.
[http://dx.doi.org/10.1210/endo.139.10.6216] [PMID: 9751507]
[108]
Dip R, Lenz S, Antignac J-P, Le Bizec B, Gmuender H, Naegeli H. Global gene expression profiles induced by phytoestrogens in human breast cancer cells. Endocr Relat Cancer 2008; 15(1): 161-73.
[http://dx.doi.org/10.1677/ERC-07-0252] [PMID: 18310284]
[109]
Ricci E, Cipriani S, Chiaffarino F, Malvezzi M, Parazzini F. Soy isoflavones and bone mineral density in perimenopausal and postmenopausal Western women: a systematic review and meta-analysis of randomized controlled trials. J Womens Health (Larchmt) 2010; 19(9): 1609-17.
[http://dx.doi.org/10.1089/jwh.2010.2021] [PMID: 20673147]
[110]
Weaver CM, Cheong JM. Soy isoflavones and bone health: the relationship is still unclear. J Nutr 2005; 135(5): 1243-7.
[http://dx.doi.org/10.1093/jn/135.5.1243] [PMID: 15867312]
[111]
Adlercreutz H, Mazur W. Phyto-oestrogens and Western diseases. Ann Med 1997; 29(2): 95-120.
[http://dx.doi.org/10.3109/07853899709113696] [PMID: 9187225]
[112]
Somekawa Y, Chiguchi M, Ishibashi T, Aso T. Soy intake related to menopausal symptoms, serum lipids, and bone mineral density in postmenopausal Japanese women. Obstet Gynecol 2001; 97(1): 109-15.
[PMID: 11152918]
[113]
Koh WP, Wu AH, Wang R, et al. Gender-specific associations between soy and risk of hip fracture in the Singapore Chinese Health Study. Am J Epidemiol 2009; 170(7): 901-9.
[http://dx.doi.org/10.1093/aje/kwp220] [PMID: 19720865]
[114]
Zhang X, Shu XO, Li H, et al. Prospective cohort study of soy food consumption and risk of bone fracture among postmenopausal women. Arch Intern Med 2005; 165(16): 1890-5.
[http://dx.doi.org/10.1001/archinte.165.16.1890] [PMID: 16157834]
[115]
Matthews VL, Knutsen SF, Beeson WL, Fraser GE. Soy milk and dairy consumption is independently associated with ultrasound attenuation of the heel bone among postmenopausal women: the Adventist Health Study-2. Nutr Res 2011; 31(10): 766-75.
[http://dx.doi.org/10.1016/j.nutres.2011.09.016] [PMID: 22074801]
[116]
Marini H, Bitto A, Altavilla D, et al. Breast safety and efficacy of genistein aglycone for postmenopausal bone loss: a follow-up study. J Clin Endocrinol Metab 2008; 93(12): 4787-96.
[http://dx.doi.org/10.1210/jc.2008-1087] [PMID: 18796517]
[117]
Atkinson C, Compston JE, Day NE, Dowsett M, Bingham SA. The effects of phytoestrogen isoflavones on bone density in women: a double-blind, randomized, placebo-controlled trial. Am J Clin Nutr 2004; 79(2): 326-33.
[http://dx.doi.org/10.1093/ajcn/79.2.326] [PMID: 14749241]
[118]
Lambert MNT, Hu LM, Jeppesen PB. A systematic review and meta-analysis of the effects of isoflavone formulations against estrogen-deficient bone resorption in peri- and postmenopausal women. Am J Clin Nutr 2017; 106(3): 801-11.
[http://dx.doi.org/10.3945/ajcn.116.151464]
[119]
Abdi F, Alimoradi Z, Haqi P, Mahdizad F. Effects of phytoestrogens on bone mineral density during the menopause transition: a systematic review of randomized, controlled trials. Climacteric 2016; 19(6): 535-45.
[http://dx.doi.org/10.1080/13697137.2016.1238451]
[120]
Albertazzi P. Purified phytoestrogens in postmenopausal bone health: is there a role for genistein? Climacteric 2002; 5(2): 190-6.
[http://dx.doi.org/10.1080/cmt.5.2.190.196] [PMID: 12051115]
[121]
Islam MA, Punt A, Spenkelink B, Murk AJ, Rolaf van Leeuwen FX, Rietjens IMCM. Conversion of major soy isoflavone glucosides and aglycones in in vitro intestinal models. Mol Nutr Food Res 2014; 58(3): 503-15.
[http://dx.doi.org/10.1002/mnfr.201300390] [PMID: 24668774]
[122]
Miura A, Sugiyama C, Sakakibara H, Simoi K, Goda T. Bioavailability of isoflavones from soy products in equol producers and non-producers in Japanese women. J Nutr Intermed Metab 2016; 6: 41-7.
[http://dx.doi.org/10.1016/j.jnim.2016.08.001]
[123]
Okabe Y, Shimazu T, Tanimoto H. Higher bioavailability of isoflavones after a single ingestion of aglycone-rich fermented soybeans compared with glucoside-rich non-fermented soybeans in Japanese postmenopausal women. J Sci Food Agric 2011; 91(4): 658-63.
[http://dx.doi.org/10.1002/jsfa.4228] [PMID: 21104834]
[124]
Cashman KD. Diet, nutrition, and bone health. J Nutr 2007; 137(11)(Suppl.): 2507S-12S.
[http://dx.doi.org/10.1093/jn/137.11.2507S] [PMID: 17951494]
[125]
Tang AL, Walker KZ, Wilcox G, Strauss BJ, Ashton JF, Stojanovska L. Calcium absorption in Australian osteopenic post-menopausal women: an acute comparative study of fortified soymilk to cows’ milk. Asia Pac J Clin Nutr 2010; 19(2): 243-9.
[PMID: 20460239]
[126]
Zhao Y, Martin BR, Weaver CM. Calcium bioavailability of calcium carbonate fortified soymilk is equivalent to cow’s milk in young women. J Nutr 2005; 135(10): 2379-82.
[http://dx.doi.org/10.1093/jn/135.10.2379] [PMID: 16177199]

Rights & Permissions Print Cite
Article Metrics
52
4
© 2024 Bentham Science Publishers | Privacy Policy