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Letters in Organic Chemistry

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ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

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Letter Article

Di[(R)-2-ethylhexyl] Phthalate, a Bioactive Metabolite First Isolated from Three Different Bacillus Species, and its Synthesis

Author(s): Miriam Castro, Jacqueline Jiménez, Aurelio Ortiz* and Estibaliz Sansinenea*

Volume 17, Issue 2, 2020

Page: [90 - 95] Pages: 6

DOI: 10.2174/1570178616666190718125617

Price: $65

Abstract

Di(2-ethylhexyl) phthalate (DEHP) is the most common phthalate ester, which has been used as a plasticizer for the production of numerous polymers, particularly polyvinyl chloride (PVC). Many other groups have synthesized meso-DEHP indicating interest in this molecule, but we are the first to synthesize enantiomerically pure di[(R)-2-ethylhexyl] phthalate. We report herein, for the first time, the isolation - from the cultures of Bacillus thuringiensis, B. subtilis, and B. velezensis strains - of di[(R)-2-ethylhexyl] phthalate, enantiomerically pure and in good yields: its biological activity against bacteria and fungi was probed and for the first time its synthesis was done.

Keywords: Di(2-ethylhexyl) phthalate, plasticizer, secondary metabolites, synthesis of enantiomers.

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