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General Review Article

miRNA，lncRNA和circRNA在骨关节炎中的治疗潜力和作用

卷 19, 期 4, 2019

页: [255 - 263] 页: 9

弟呕挨: 10.2174/1566523219666190716092203

价格: $65

摘要

背景：骨关节炎（OA）是一种以进行性变性，关节增生，关节间隙变窄和细胞外基质代谢为特征的疾病。最近的研究表明，OA的发病机制可能与非编码RNA有关，其病理机制可能是降低OA的有效途径。 目的：本综述旨在探讨miRNA，长非编码RNA（lncRNA）和环状RNA（circRNA）在OA基因治疗中的最新进展，探讨该RNA对基因表达，炎症反应，细胞凋亡和细胞外作用的影响。 OA中的矩阵。 方法：搜索以下电子数据库，包括PubMed，EMBASE，Web of Science和Cochrane库，以查找涉及OA中miRNA，lncRNA和circRNA的已发表研究。结果包括基因表达，炎症反应，细胞凋亡和细胞外基质。 结果与讨论：随着技术的发展，已经在许多疾病中发现了miRNA，lncRNA和circRNA。更重要的是，最近的研究发现RNA与RNA结合蛋白相互作用以调节基因转录和蛋白翻译，并参与OA的各种病理过程，因此成为OA的潜在疗法。 结论：在本文中，我们简要介绍了miRNA，lncRNA和circRNA在OA发生和发展中的作用以及作为基因治疗的新靶标。

关键词: 骨关节炎，miRNA，lncRNA，circRNA，新靶标，基因治疗。

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