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General Review Article

宿主的遗传标记，以预测大肠癌靶向治疗的功效

卷 27, 期 25, 2020

页: [4249 - 4273] 页: 25

弟呕挨: 10.2174/0929867326666190712151417

价格: $65

摘要

在转移性_直肠直肠癌（CRC）治疗中引入抗EGFR（西妥昔单抗和帕尼单抗）和抗血管生成药（贝伐单抗，雷戈非宁，雷莫昔单抗和阿柏西普）药物可显着改善治疗效果和患者生存率。然而，尽管在患者预期寿命方面取得了很大的进步，但是针对靶向药物的个体间高度异质性仍然代表着晚期CRC患者的治疗问题。即使已经明确确立了肿瘤基因突变作为药物功效的预测标志物的作用，但宿主遗传标志物的作用仍然存在争议。有希望的结果涉及种系的免疫特性，炎症和肿瘤微环境。研究了KRAS 3’UTR区以及EGF / EGFR基因的固有变异作为西妥昔单抗有效性的标志。最近还针对涉及炎症（例如COX-2，LIFR，IGF1信号传导），免疫系统（例如FCGR，IL-1RA）和炎症的基因的种系变异生成了抗EGFR剂领域的有趣数据。 RAS信号的其他参与者，包括与Hippo通路相关的基因（例如Rassf，YAP，TAZ）。宿主的遗传变异，依赖于VEGF依赖性（即EGF，IGF-1，HIF1α，eNOS，iNOS）和非依赖性（即EMT级联，EGFL7）途径，尤其是炎症和免疫系统相关因子（例如IL） -8，CXCR-1 / 2，CXCR4-CXCL12轴，TLR，GADD34，PPP1R15A，ANXA11，MKNK1）作为贝伐单抗预后的预测标志物进行了研究，产生了可喜的结果。在这篇综述中，我们旨在总结有关常见和罕见遗传变异在预测哪些CRC患者将从特定靶向药物治疗中受益的潜在作用的最新文献数据。

关键词: 靶向药物，抗血管生成分子，贝伐单抗，抗EGFR药物，西妥昔单抗，药物遗传学，多态性，炎症，转移性结直肠癌。

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