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Review Article

肌肽和肺病

卷 27, 期 11, 2020

页: [1714 - 1725] 页: 12

弟呕挨: 10.2174/0929867326666190712140545

价格: $65

摘要

肌肽（β-丙氨酰-L-组氨酸）是一种小二肽，具有多种活性，包括抗氧化作用，金属离子螯合，质子缓冲能力以及对蛋白质羰基化和糖基化的抑制作用。肌肽主要在丰富的器官中进行研究，包括骨骼肌，大脑皮层，肾脏，脾脏和血浆。近来，在流感病毒或脂多糖诱导的急性肺损伤和肺纤维化的动物模型中，已经在肌肽水平低的器官如肺中研究了肌肽补充作用。在肌肽的已知保护作用中，其抗氧化作用已被潜在地用于治疗肺部疾病而引起越来越多的关注。在这篇综述中，我们描述了肌肽的体外和体内生物学和生理学作用。我们还报告了我们最近的研究，并讨论了肌肽或其相关化合物在肌肽仅少量（尤其是肺）存在的器官中的作用及其保护机制。

关键词: 肌肽，活性氧（ROS），急性肺损伤，肽，抗氧化剂，氧化应激。

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