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Review Article

炎症是抑郁症和心血管疾病之间的常见生物学联系：肌肽能否发挥保护作用？

卷 27, 期 11, 2020

页: [1782 - 1800] 页: 19

弟呕挨: 10.2174/0929867326666190712091515

价格: $65

摘要

几项流行病学研究清楚地显示出抑郁症和心血管疾病（CVD）的高合并症。已经进行了不同的研究来确定这些疾病的常见病理生理事件，例如下丘脑-垂体-肾上腺轴的过度活化，最重要的是，免疫系统失调会导致慢性促炎状态。抑郁症，炎症和CVD之间的生物学联系可能与巨噬细胞释放的高水平促炎性细胞因子（例如IL-1β，TNF-α和IL-6）有关，巨噬细胞在两者的病理生理学中均起着重要作用抑郁症和CVD。促炎性细胞因子通过上调色氨酸代谢途径中的限速酶和改变5-羟色胺代谢，从而干扰了许多与抑郁有关的病理生理机制。这些细胞因子也增加了发生CVD的风险，因为在这种促炎状态下巨噬细胞的激活与内皮功能障碍和氧化应激密切相关，而内皮功能异常和氧化应激是动脉粥样硬化和动脉粥样硬化的序言。 肌肽（β-丙氨酰-L-组氨酸）是一种内源性二肽，通过抑制反应性物种和促炎细胞因子的产生并改变促炎/消炎巨噬细胞的极化，对巨噬细胞发挥强大的抗炎活性。该二肽具有抗氧化特性，可清除反应性物种并防止氧化应激诱导的病理，例如CVD。 在本综述中，我们将讨论氧化应激和慢性炎症在抑郁症和CVD中作为常见病理生理事件的作用，以及肌肽对这两种疾病的保护作用以及这种二肽在抑郁症中的治疗潜力的临床前和临床证据。心血管疾病高合并症的患者。

关键词: 肌肽，炎症，氧化应激，抑郁症，心血管疾病，巨噬细胞。

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