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Review Article

临床前药物评估的技术进展：组学方法的作用

卷 27, 期 8, 2020

页: [1337 - 1349] 页: 13

弟呕挨: 10.2174/0929867326666190711122819

价格: $65

摘要

临床前药物开发是药物开发过程中必不可少的步骤，其中需要对新的化学实体进行评估。 特别是，临床前药物开发阶段包括通过使用体外和体内动物试验，深入分析候选药物与生物分子/靶标的相互作用，其安全性，毒性，药代动力学，代谢。 所需程序的法律方面是公认的。 本文中，我们对临床前研究中使用的最新技术和方法进行了全面的总结。 特别是，我们将审查新的组学方法和平台对候选药物进行机械评估以及加快临床前评估步骤的潜力。

关键词: 药物测试，蛋白质组学，转录组学，质谱，临床前药物评估，组学方法。

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