Review Article

抗VEGF治疗与年龄相关性黄斑变性的反应:疾病的易感性,药物遗传学和药代动力学

卷 27, 期 4, 2020

页: [549 - 569] 页: 21

弟呕挨: 10.2174/0929867326666190711105325

价格: $65

摘要

当前的审查集中在与年龄相关性黄斑变性(AMD)的发作和进展直接相关的不同因素上。特别是基于遗传和非遗传因素对AMD的易感性以及建立风险评分的基础上,是基于对不同基因的分析以衡量患病的风险。从药物动力学和药物遗传学的观点来看,与治疗AMD患者的实际治疗前景也存在相关性。在试图将个人分为“响应者”和“非响应者”时,常用的治疗方法以及不同的给药方式尤其重要。还将审查与药物反应相关的不同基因的分析,以及作为早期AMD检测和反应的可能生物标志物的microRNA(miRNA)的新兴领域。本文旨在从分子和动力学的角度为读者提供与AMD相关的不同出版物的综述,以及它的常用治疗方法,主要陷阱和未来方向,据我们所知,这些方法可能会引起评估和关注为了为AMD开发个性化的医学模型。

关键词: 易感性,药物遗传学,药物动力学,治疗,与年龄有关的黄斑变性,抗VEGF。

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