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Review Article

基于免疫的颅脑外伤治疗：来自临床前研究的见解

卷 27, 期 32, 2020

页: [5374 - 5402] 页: 29

弟呕挨: 10.2174/0929867326666190710173234

价格: $65

摘要

外伤性脑损伤（TBI）是主要的公共健康问题。 它是导致死亡和残疾的主要原因，尤其是在儿童和年轻人中。 TBI病理生理学的神经生物学基础仍有待充分揭示。 在过去的几年中，越来越多的证据支持TBI是基于炎症的疾病这一假说，为潜在治疗靶标的开发铺平了道路。 没有能够预防或最小化TBI相关结果的治疗方法。 因此，寻找有效疗法是一个优先目标。 在这种情况下，动物模型已成为研究TBI发病机理以及新型治疗方法的分子和细胞机制的有价值的工具。 在本文中，我们讨论在临床前环境中以免疫调节和/或抗炎方法为主的TBI治疗策略。

关键词: 颅脑外伤，炎症，治疗，免疫调节剂，抗炎，发病机理。

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