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Review Article

血红素加氧酶1在青少年自身免疫性疾病中的功能免疫调节作用

卷 19, 期 2, 2019

页: [110 - 116] 页: 7

弟呕挨: 10.2174/1566523219666190710092935

价格: $65

摘要

自身免疫疾病是一种炎症性疾病，其中人体的免疫系统攻击正常细胞，导致免疫功能降低和异常，最终导致组织损伤或器官功能障碍。在医学领域，尤其是儿科领域，关于自身免疫性疾病的知识仍然不足。一些常见的青少年自身免疫性疾病，如过敏性紫癜，全身性幼年特发性关节炎，粘膜皮肤淋巴结综合征和自身免疫性脑炎引起了公众的广泛关注。最近的研究表明，血红素加氧酶1（HO-1）是一种参与血红素降解的酶，在发病机制中起着关键作用，可能调节自身免疫。首先，它可以促进T淋巴细胞分化成CD4 + CD25 +调节性T细胞，并且可能与细胞因子（Th1 / Th2和Th17 / Treg）比例的变化有关。其次，HO-1可通过转化生长因子和白细胞介素等蛋白质的分泌来调节免疫系统。此外，增加HO-1的表达可以通过增加抗氧化剂水平来改善血管功能。因此，HO-1可为青少年自身免疫疾病的治疗管理提供理论依据和指导。

关键词: 青少年自身免疫性疾病，血红素加氧酶1，促炎细胞因子，炎性细胞因子，T淋巴细胞，MCLS。

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图形摘要

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