Review Article

在天果神话的背后,关于Gac(Momordica cochinchinensis Spreng。)对营养的贡献的批判性评论

卷 26, 期 24, 2019

页: [4585 - 4605] 页: 21

弟呕挨: 10.2174/0929867326666190705154723

价格: $65

conference banner
摘要

Gac,苦瓜(Lour。) 属于葫芦科。 它被认为是超级水果。 在其声誉很高的国家中,对这种植物的需求正在增长,其中包括传统的gac栽培国家以及喜欢超级水果和食品补品的国家。 在这些后面的国家中,工业战略旨在在食品补充剂或营养丰富的制剂中实现高附加值。 但是,当营销不是推动力并且主张必须与科学数据相关时,gac的情况就不太“泛滥”了,这主要是因为其最显着的特性是在微量营养素领域。 后面这些成分确实对健康非常重要,但是对健康人群的补充并没有带来明显的优势。 本文建议回顾对这种植物的营养声誉具有重要意义的方面:其来源,如何培养以具有最佳营养成分,其成分是什么以及如何影响消费者的健康,以及在何种产品中使用 以及在不同市场使用它的法规是什么。 这次审查的一个重要目标是提供一种批判性和科学性的方法来确认有关这种水果的数据,这是由营销部门注入大量错误和未经验证的信息所推动的。 缺少的数据将突出显示,并在全文中提出潜在的积极应用。

关键词: 胡萝卜素,gac(Momordica cochinchinensis),番茄红素,食品补充剂,微量营养素,最佳营养成分。

[1]
Chuyen, H.V. Gac fruit (Momordica cochinchinensis Spreng.): a rich source of bioactive compounds and its potential health benefits. Int. J. Food Sci. Technol., 2015, 50(3), 567-577.
[http://dx.doi.org/10.1111/ijfs.12721]
[2]
Vuong, T.; Dueker, S.R.; Murphy, S.P. Plasma β-carotene and retinol concentrations of children increase after a 30-d supplementation with the fruit Momordica cochinchinensis (gac). Am. J. Clin. Nutr., 2002, 75(5), 872-879.
[http://dx.doi.org/10.1093/ajcn/75.5.872] [PMID: 11976161]
[3]
Wong, R.C.H.; Fong, W.P.; Ng, T.B. Multiple trypsin inhibitors from Momordica cochinchinensis seeds, the Chinese drug mubiezhi. Peptides, 2004, 25(2), 163-169.
[http://dx.doi.org/10.1016/j.peptides.2004.01.002] [PMID: 15062996]
[4]
Kubola, J.; Siriamornpun, S. Phytochemicals and antioxidant activity of different fruit fractions (peel, pulp, aril and seed) of Thai gac (Momordica cochinchinensis Spreng). Food Chem., 2011, 127(3), 1138-1145.
[http://dx.doi.org/10.1016/j.foodchem.2011.01.115] [PMID: 25214106]
[5]
Ong, H.C.; Mojiun, P.F.J.; Milow, P. Traditional knowledge of edible plants among the Temuan villagers in Kampung Guntor, Negeri Sembilan, Malaysia. Afr. J. Agric. Res., 2011, 6(8), 1962-1965.
[6]
Kha, T.C. Gac Fruit: Nutrient and Phytochemical Composition, and Options for Processing. Food Rev. Int., 2013, 29, 92-106.
[http://dx.doi.org/10.1080/87559129.2012.692141]
[7]
Lim, T.K. Momordica cochinchinensis.Edible Medicinal And Non-Medicinal Plants; Lim, T.K., Ed.; Springer, 2012, pp. 369-380.
[http://dx.doi.org/10.1007/978-94-007-1764-0_48]
[8]
Lévi, S.; Przyluski, J.; Bloch, J. Die Turzismen in der Sprache der Kroaten und Serben; Calcutta, 1929.
[9]
Decker-Walters, D.S. Cucurbits, Sanskrit, and the Indo-Aryas. Econ. Bot., 1999, 53(1), 98-112.
[http://dx.doi.org/10.1007/BF02860800]
[10]
Ishida, B.K.; Turner, C.; Chapman, M.H.; McKeon, T.A. Fatty acid and carotenoid composition of gac (Momordica cochinchinensis Spreng) fruit. J. Agric. Food Chem., 2004, 52(2), 274-279.
[http://dx.doi.org/10.1021/jf030616i] [PMID: 14733508]
[11]
Dang, T.T.N. Changes in lycopene and beta carotene contents in aril and oil of gac fruit during storage. Food Chem., 2010, 121(2), 326-331.
[http://dx.doi.org/10.1016/j.foodchem.2009.12.032]
[12]
Hyun, T.K.; Rim, Y.; Jang, H.J.; Kim, C.H.; Park, J.; Kumar, R.; Lee, S.; Kim, B.C.; Bhak, J.; Nguyen-Quoc, B.; Kim, S.W.; Lee, S.Y.; Kim, J.Y. De novo transcriptome sequencing of Momordica cochinchinensis to identify genes involved in the carotenoid biosynthesis. Plant Mol. Biol., 2012, 79(4-5), 413-427.
[http://dx.doi.org/10.1007/s11103-012-9919-9] [PMID: 22580955]
[13]
Parks, S.E. Propagation and production of Gac (Momordica cochinchinensis Spreng.), a greenhouse case study. Exp. Agric., 2013, 49(02), 234-243.
[http://dx.doi.org/10.1017/S0014479712001081]
[14]
Parks, S. et al., Assessing the Potential for a Gac (Cochinchin gourd) Industry in Australia. , 2013. Australia..
[15]
[16]
DellaPenna, D.; Pogson, B.J. Vitamin synthesis in plants: tocopherols and carotenoids. Annu. Rev. Plant Biol., 2006, 57(1), 711-738.
[http://dx.doi.org/10.1146/annurev.arplant.56.032604.144301] [PMID: 16669779]
[17]
Ronen, G.; Cohen, M.; Zamir, D.; Hirschberg, J. Regulation of carotenoid biosynthesis during tomato fruit development: expression of the gene for lycopene epsilon-cyclase is down-regulated during ripening and is elevated in the mutant Delta. Plant J., 1999, 17(4), 341-351.
[http://dx.doi.org/10.1046/j.1365-313X.1999.00381.x] [PMID: 10205893]
[18]
Heider, S.A.E.; Wolf, N.; Hofemeier, A.; Peters-Wendisch, P.; Wendisch, V.F. Optimization of the IPP precursor supply for the production of lycopene, decaprenoxanthin and astaxanthin by Corynebacterium glutamicum. Front. Bioeng. Biotechnol., 2014, 2, 28.
[http://dx.doi.org/10.3389/fbioe.2014.00028] [PMID: 25191655]
[19]
Aoki, H.; Kieu, N.T.; Kuze, N.; Tomisaka, K.; Van Chuyen, N. Carotenoid pigments in GAC fruit (Momordica cochinchinensis SPRENG). Biosci. Biotechnol. Biochem., 2002, 66(11), 2479-2482.
[http://dx.doi.org/10.1271/bbb.66.2479] [PMID: 12506992]
[20]
Kubola, J.; Meeso, N.; Siriamornpun, S. Lycopene and beta carotene concentration in aril oil of gac (Momordica cochinchinensis Spreng) as influenced by aril-drying process and solvents extraction. Food Res. Int., 2013, 50(2), 664-669.
[http://dx.doi.org/10.1016/j.foodres.2011.07.004]
[21]
Vuong, L.T. Momordica cochinchinensis (Spreng.) bcarotene and method; United States Patent 2004.
[22]
Vuong, L.T. Momordica cochinchinensis Spreng. (gac) fruit carotenoids reevaluated. J. Food Compos. Anal., 2006, 19, 664-668.
[http://dx.doi.org/10.1016/j.jfca.2005.02.001]
[23]
Bharathi, L.K.; Munshi, A.D. Vinod; Chandrashekaran, S.; Behera, T.K.; Das, A.B.; John, K.J.; Vishalnath, Cytotaxonomical analysis of Momordica L. (Cucurbitaceae) species of Indian occurrence. J. Genet., 2011, 90(1), 21-30.
[http://dx.doi.org/10.1007/s12041-011-0026-5] [PMID: 21677385]
[24]
Nagarani, G.; Abirami, A.; Siddhuraju, P. Food prospects and nutraceutical attributes of Momordica species: A potential tropical bioresources – A review. Food Sci. Hum. Wellness, 2014, 3(3), 117-126.
[http://dx.doi.org/10.1016/j.fshw.2014.07.001]
[25]
Iwamoto, M. Studies on the Constituents of Momordica cochinchinensis SPRENG. I. Isolation and Characterization of the Seed Saponins, Momordica Sapponins I and II. Chem. Pharm. Bull. (Tokyo), 1985, 33(2), 464-478.
[http://dx.doi.org/10.1248/cpb.33.464]
[26]
Xiao, C.; Hu, S.; Rajput, Z.I. Adjuvant effect of an extract from Cochinchina momordica seeds on the immune responses to ovalbumin in mice. Front. Agric. China, 2007, 1(1), 90-95.
[http://dx.doi.org/10.1007/s11703-007-0017-8]
[27]
Iwamoto, M.; Okabe, H.; Yamauchi, T. Studies on the Constituents of Momordica cochinchinensis SPRENG. II. Isolation and Characterization of the Root Saponins, Momordins I, II and III. Chem. Pharm. Bull. (Tokyo), 1985, 33(1), 1-7.
[http://dx.doi.org/10.1248/cpb.33.1]
[28]
Jung, K.; Lee, D.; Yu, J.S.; Namgung, H.; Kang, K.S.; Kim, K.H. Protective effect and mechanism of action of saponins isolated from the seeds of gac (Momordica cochinchinensis Spreng.) against cisplatin-induced damage in LLC-PK1 kidney cells. Bioorg. Med. Chem. Lett., 2016, 26(5), 1466-1470.
[http://dx.doi.org/10.1016/j.bmcl.2016.01.056] [PMID: 26838808]
[29]
Yu, J.S.; Kim, J.H.; Lee, S.; Jung, K.; Kim, K.H.; Cho, J.Y. Src/Syk-Targeted Anti-Inflammatory Actions of Triterpenoidal Saponins from Gac (Momordica cochinchinensis) Seeds. Am. J. Chin. Med., 2017, 45(3), 459-473.
[http://dx.doi.org/10.1142/S0192415X17500288] [PMID: 28367713]
[30]
Zheng, L.; Zhang, Y.; Liu, Y.; Yang, X.O.; Zhan, Y. Momordica cochinchinensis Spreng. seed extract suppresses breast cancer growth by inducing cell cycle arrest and apoptosis. Mol. Med. Rep., 2015, 12(4), 6300-6310.
[http://dx.doi.org/10.3892/mmr.2015.4186] [PMID: 26252798]
[31]
Guichard, F.; Bui, D.S. La matiere colorante du fruit du Momordica cochinchinnensis spreng Annales de l’ecole Superieure de Medecine et de Pharmacie de l’Indochine, 1941, 5, 141-142.
[32]
Stahl, W.; Sies, H. Lycopene: a biologically important carotenoid for humans? Arch. Biochem. Biophys., 1996, 336(1), 1-9.
[http://dx.doi.org/10.1006/abbi.1996.0525] [PMID: 8951028]
[33]
Kha, T.C. Effects of different drying processes on the phys-icochemical and antioxidant properties of gac fruit powder,
The University of Newcastle: Newcastle, Australia , 2010.
[34]
Ngan, N.T.K.; Hung, N.; Huynh, T.M. Phong chong ung thu gan (Liver cancer prevention). Y Hoc Viet Nam, 1993, 5(171), 81-88.
[35]
Phan-Thi, H.; Waché, Y. Isomerization and increase in the antioxidant properties of lycopene from Momordica cochinchinensis (gac) by moderate heat treatment with UV-Vis spectra as a marker. Food Chem., 2014, 156(0), 58-63.
[http://dx.doi.org/10.1016/j.foodchem.2014.01.040] [PMID: 24629938]
[36]
Phan-Thi, H.; Durand, P.; Prost, M.; Prost, E.; Waché, Y. Effect of heat-processing on the antioxidant and prooxidant activities of β-carotene from natural and synthetic origins on red blood cells. Food Chem., 2016, 190, 1137-1144.
[http://dx.doi.org/10.1016/j.foodchem.2015.06.088] [PMID: 26213087]
[37]
Kubatka, P.; Kapinová, A.; Kružliak, P.; Kello, M.; Výbohová, D.; Kajo, K.; Novák, M.; Chripková, M.; Adamkov, M.; Péč, M.; Mojžiš, J.; Bojková, B.; Kassayová, M.; Stollárová, N.; Dobrota, D. Antineoplastic effects of Chlorella pyrenoidosa in the breast cancer model. Nutrition, 2015, 31(4), 560-569.
[http://dx.doi.org/10.1016/j.nut.2014.08.010] [PMID: 25770318]
[38]
Trejo-Solís, C.; Pedraza-Chaverrí, J.; Torres-Ramos, M.; Jiménez-Farfán, D.; Cruz Salgado, A.; Serrano-García, N.; Osorio-Rico, L.; Sotelo, J. Multiple molecular and cellular mechanisms of action of lycopene in cancer inhibition. Evid. Based Complement. Alternat. Med., 2013.2013705121
[http://dx.doi.org/10.1155/2013/705121] [PMID: 23970935]
[39]
Erdman, J.W., Jr; Ford, N.A.; Lindshield, B.L. Are the health attributes of lycopene related to its antioxidant function? Arch. Biochem. Biophys., 2009, 483(2), 229-235.
[http://dx.doi.org/10.1016/j.abb.2008.10.022] [PMID: 18983972]
[40]
Ilic, D.; Forbes, K.M.; Hassed, C. Lycopene for the prevention of prostate cancer. Cochrane Database of Systematic Reviews, ., 2011.
[http://dx.doi.org/10.1002/14651858.CD008007.pub2]
[41]
Omenn, G.S.; Goodman, G.E.; Thornquist, M.D.; Balmes, J.; Cullen, M.R.; Glass, A.; Keogh, J.P.; Meyskens, F.L.; Valanis, B.; Williams, J.H.; Barnhart, S.; Hammar, S. Effects of a combination of beta carotene and vitamin A on lung cancer and cardiovascular disease. N. Engl. J. Med., 1996, 334(18), 1150-1155.
[http://dx.doi.org/10.1056/NEJM199605023341802] [PMID: 8602180]
[42]
Baker, D.L.; Krol, E.S.; Jacobsen, N.; Liebler, D.C. Reactions of β-carotene with cigarette smoke oxidants. Identification of carotenoid oxidation products and evaluation of the prooxidant/antioxidant effect. Chem. Res. Toxicol., 1999, 12(6), 535-543.
[http://dx.doi.org/10.1021/tx980263v] [PMID: 10368317]
[43]
Wang, X-D.; Russell, R.M. Procarcinogenic and anticarcinogenic effects of β-carotene. Nutr. Rev., 1999, 57(9 Pt 1), 263-272.
[PMID: 10568335]
[44]
Almeida, I.V.; Düsman, E.; Heck, M.C.; Pamphile, J.A.; Lopes, N.B.; Tonin, L.T.; Vicentini, V.E. Cytotoxic and mutagenic effects of iodine-131 and radioprotection of acerola (Malpighia glabra L.) and beta-carotene in vitro. Genet. Mol. Res., 2013, 12(4), 6402-6413.
[http://dx.doi.org/10.4238/2013.December.10.1] [PMID: 24390989]
[45]
Hennekens, C.H.; Buring, J.E.; Manson, J.E.; Stampfer, M.; Rosner, B.; Cook, N.R.; Belanger, C.; LaMotte, F.; Gaziano, J.M.; Ridker, P.M.; Willett, W.; Peto, R. Lack of effect of long-term supplementation with beta carotene on the incidence of malignant neoplasms and cardiovascular disease. N. Engl. J. Med., 1996, 334(18), 1145-1149.
[http://dx.doi.org/10.1056/NEJM199605023341801] [PMID: 8602179]
[46]
Sommerburg, O.; Langhans, C.D.; Arnhold, J.; Leichsenring, M.; Salerno, C.; Crifò, C.; Hoffmann, G.F.; Debatin, K.M.; Siems, W.G. β-carotene cleavage products after oxidation mediated by hypochlorous acid--a model for neutrophil-derived degradation. Free Radic. Biol. Med., 2003, 35(11), 1480-1490.
[http://dx.doi.org/10.1016/j.freeradbiomed.2003.08.020] [PMID: 14642396]
[47]
Eroglu, A.; Hruszkewycz, D.P.; dela Sena, C.; Narayanasamy, S.; Riedl, K.M.; Kopec, R.E.; Schwartz, S.J.; Curley, R.W., Jr; Harrison, E.H. Naturally occurring eccentric cleavage products of provitamin A β-carotene function as antagonists of retinoic acid receptors. J. Biol. Chem., 2012, 287(19), 15886-15895.
[http://dx.doi.org/10.1074/jbc.M111.325142] [PMID: 22418437]
[48]
Arora, A.; Willhite, C.A.; Liebler, D.C. Interactions of β-carotene and cigarette smoke in human bronchial epithelial cells. Carcinogenesis, 2001, 22(8), 1173-1178.
[http://dx.doi.org/10.1093/carcin/22.8.1173] [PMID: 11470745]
[49]
Lowe, G.M.; Booth, L.A.; Young, A.J.; Bilton, R.F. Lycopene and β-carotene protect against oxidative damage in HT29 cells at low concentrations but rapidly lose this capacity at higher doses. Free Radic. Res., 1999, 30(2), 141-151.
[http://dx.doi.org/10.1080/10715769900300151] [PMID: 10193582]
[50]
Yeh, S.L.; Huang, C.S.; Hu, M.L. Lycopene enhances UVA-induced DNA damage and expression of heme oxygenase-1 in cultured mouse embryo fibroblasts. Eur. J. Nutr., 2005, 44(6), 365-370.
[http://dx.doi.org/10.1007/s00394-004-0536-5] [PMID: 15549328]
[51]
Failla, M.L.; Chitchumroonchokchai, C.; Ishida, B.K. In vitro micellarization and intestinal cell uptake of cis isomers of lycopene exceed those of all-trans lycopene. J. Nutr., 2008, 138(3), 482-486.
[http://dx.doi.org/10.1093/jn/138.3.482] [PMID: 18287353]
[52]
Abdel-Aal, S.M.; Akhtar, H.; Zaheer, K.; Ali, R. Dietary sources of lutein and zeaxanthin carotenoids and their role in eye health. Nutrients, 2013, 5(4), 1169-1185.
[http://dx.doi.org/10.3390/nu5041169] [PMID: 23571649]
[53]
Cao Hoang, L.; Waché, Y. Carotene dispersion in liquid media.Beta-Carotene; Dietary Sources, C; Cognition, L.H.T.B., Ed.; Novapublishers: Hauppauge, NY, 2009, pp. 283-298.
[54]
Vo, V-C., Ed.; A Dictionary of Medicinal Plants of Vietnam; Ho-Chi-Minh City, 2007.
[55]
Ames, B.N.; Shigenaga, M.K.; Hagen, T.M. Oxidants, antioxidants, and the degenerative diseases of aging. Proc. Natl. Acad. Sci. USA, 1993, 90(17), 7915-7922.
[http://dx.doi.org/10.1073/pnas.90.17.7915] [PMID: 8367443]
[56]
Knekt, P.; Heliövaara, M.; Rissanen, A.; Aromaa, A.; Aaran, R.K. Serum antioxidant vitamins and risk of cataract. BMJ, 1992, 305(6866), 1392-1394.
[http://dx.doi.org/10.1136/bmj.305.6866.1392] [PMID: 1486302]
[57]
AREDS_Research_Group, A Randomized, Placebo- Controlled, Clinical Trial of High-Dose Supplementation With Vitamins C and E, Beta Carotene, and Zinc for Age- Related Macular Degeneration and Vision Loss: AREDS Report No. 8, A.o. Ophthalmology, Editor. 2001, National Institutes of Health: Rockville; , 2001.
[58]
Christen, W.G.; Manson, J.E.; Glynn, R.J.; Gaziano, J.M.; Sperduto, R.D.; Buring, J.E.; Hennekens, C.H. A randomized trial of beta carotene and age-related cataract in US physicians. Arch. Ophthalmol., 2003, 121(3), 372-378.
[http://dx.doi.org/10.1001/archopht.121.3.372] [PMID: 12617708]
[59]
Teikari, J.M.; Rautalahti, M.; Haukka, J.; Järvinen, P.; Hartman, A.M.; Virtamo, J.; Albanes, D.; Heinonen, O. Incidence of cataract operations in Finnish male smokers unaffected by α tocopherol or β carotene supplements. J. Epidemiol. Community Health, 1998, 52(7), 468-472.
[http://dx.doi.org/10.1136/jech.52.7.468] [PMID: 9799882]
[60]
Scripsema, N.K.; Hu, D-N.; Rosen, R.B. Lutein, Zeaxanthin, and meso-Zeaxanthin in the Clinical Management of Eye Disease. J.of Ophthalmol., 2015.
[61]
Hazewindus, M. The anti-inflammatory effect of lycopene complements the antioxidant action of ascorbic acid and α-tocopherol. Food Chem., 2012, 132(2), 954-958.
[http://dx.doi.org/10.1016/j.foodchem.2011.11.075]
[62]
Li, W. Anti-inflammatory effects of lycopene prevents cardiac dysfunction in streptozotocin-diabetic rats. Int. J. Clin. Exp. Med., 2016, 9(5), 8047-8054.
[63]
Cha, J.H.; Kim, W.K.; Ha, A.W.; Kim, M.H.; Chang, M.J. Anti-inflammatory effect of lycopene in SW480 human colorectal cancer cells. Nutr. Res. Pract., 2017, 11(2), 90-96.
[http://dx.doi.org/10.4162/nrp.2017.11.2.90] [PMID: 28386381]
[64]
Bai, S-K.; Lee, S.J.; Na, H.J.; Ha, K.S.; Han, J.A.; Lee, H.; Kwon, Y.G.; Chung, C.K.; Kim, Y.M. β-Carotene inhibits inflammatory gene expression in lipopolysaccharide-stimulated macrophages by suppressing redox-based NF-kappaB activation. Exp. Mol. Med., 2005, 37(4), 323-334.
[http://dx.doi.org/10.1038/emm.2005.42] [PMID: 16155409]
[65]
Uteshev, D. The anti-inflammatory activity of intal and beta-carotene in a model of experimental granulomatous lung inflammation. Patologicheskaya Fiziologiya i Eksperimentalnaya Terapiya, 2000, 2, 19-22.
[66]
Tsoi, A.Y-K.; Ng, T.B.; Fong, W.P. Immunomodulatory activity of a chymotrypsin inhibitor from Momordica cochinchinensis seeds. J. Pept. Sci., 2006, 12(9), 605-611.
[http://dx.doi.org/10.1002/psc.765] [PMID: 16733830]
[67]
Jung, K.; Chin, Y.W.; Yoon, Kd.; Chae, H.S.; Kim, C.Y.; Yoo, H.; Kim, J. Anti-inflammatory properties of a triterpenoidal glycoside from Momordica cochinchinensis in LPS-stimulated macrophages. Immunopharmacol. Immunotoxicol., 2013, 35(1), 8-14.
[http://dx.doi.org/10.3109/08923973.2012.715165] [PMID: 22916793]
[68]
Fang, Q.M.; Zhang, H.; Cao, Y.; Wang, C. Anti-inflammatory and free radical scavenging activities of ethanol extracts of three seeds used as “Bolengguazi”. J. Ethnopharmacol., 2007, 114(1), 61-65.
[http://dx.doi.org/10.1016/j.jep.2007.07.024] [PMID: 17766069]
[69]
Rajput, Z.I.; Xiao, C.W.; Hu, S.H.; Arijo, A.G.; Soomro, N.M. Improvement of the efficacy of influenza vaccination (H5N1) in chicken by using extract of Cochinchina momordica seed (ECMS). J. Zhejiang Univ. Sci. B, 2007, 8(5), 331-337.
[http://dx.doi.org/10.1631/jzus.2007.B0331] [PMID: 17542061]
[70]
Xiao, C.; Bao, G.; Hu, S. Enhancement of immune responses to Newcastle disease vaccine by a supplement of extract of Momordica cochinchinensis (Lour.) Spreng. seeds. Poult. Sci., 2009, 88(11), 2293-2297.
[http://dx.doi.org/10.3382/ps.2009-00059] [PMID: 19834078]
[71]
Xiao, C.; Rajput, Z.I.; Liu, D.; Hu, S. Enhancement of serological immune responses to foot-and-mouth disease vaccine by a supplement made of extract of cochinchina momordica seeds. Clin. Vaccine Immunol., 2007, 14(12), 1634-1639.
[http://dx.doi.org/10.1128/CVI.00339-07] [PMID: 17942610]
[72]
Malakoff, D. Public health. Aluminum is put on trial as a vaccine booster. Science, 2000, 288(5470), 1323-1324.
[http://dx.doi.org/10.1126/science.288.5470.1323] [PMID: 10847840]
[73]
De Shan, M.; Hu, L.H.; Chen, Z.L. A new multiflorane triterpenoid ester from Momordica cochinchinensis Spreng. Nat. Prod. Lett., 2001, 15(2), 139-145.
[http://dx.doi.org/10.1080/10575630108041271] [PMID: 11561447]
[74]
Huang, B.; Ng, T.B.; Fong, W.P.; Wan, C.C.; Yeung, H.W. Isolation of a trypsin inhibitor with deletion of N-terminal pentapeptide from the seeds of Momordica cochinchinensis, the Chinese drug mubiezhi. Int. J. Biochem. Cell Biol., 1999, 31(6), 707-715.
[http://dx.doi.org/10.1016/S1357-2725(99)00012-6] [PMID: 10404643]
[75]
Vuong, L. Underutilized beta-carotene-rich crops of Vietnam. Food Nutr. Bull., 2000, 21(2), 173-181.
[http://dx.doi.org/10.1177/156482650002100211]
[76]
Rioux, V.; Legrand, P. Saturated fatty acids: simple molecular structures with complex cellular functions. Curr. Opin. Clin. Nutr. Metab. Care, 2007, 10(6), 752-758.
[http://dx.doi.org/10.1097/MCO.0b013e3282f01a75] [PMID: 18089958]
[77]
Report of a Joint WHO/FAO Expert Consultation, in WHO Technical Report Series 916. 2003; World Health Organization: Geneva, 2003, 88.
[78]
Couet, C. Acides gras de la famille oméga 3 et système cardiovaculaire: intérêt nutritionnel et allégations; Afssa, Editor: Paris , 2001.
[79]
Martin, A. Apports nutritionnels conseillés pour la population française 3ème édition; Edition TECandDOC Lavoisier ed.: Paris, 2001.
[80]
[81]
Leevutinun, P.; Krisadaphong, P.; Petsom, A. Clinical evaluation of Gac extract (Momordica cochinchinensis) in an antiwrinkle cream formulation. J. Cosmet. Sci., 2015, 66(3), 175-187.
[PMID: 26454905]
[82]
Müller-Maatsch, J.; Sprenger, J.; Hempel, J.; Kreiser, F.; Carle, R.; Schweiggert, R.M. Carotenoids from gac fruit aril (Momordica cochinchinensis [Lour.] Spreng.) are more bioaccessible than those from carrot root and tomato fruit. Food Res. Int., 2017, 99(Pt 2), 928-935.
[http://dx.doi.org/10.1016/j.foodres.2016.10.053] [PMID: 28847429]
[83]
Le Grusse, J. Les vitamines, données biochimiques, nutritionnelles et cliniques; Neuilly sur Seine: CEIV - Produits Roche. , 1993.
[84]
Vassiliou, A. Authorising the placing on the market of lycopene as novel food ingredient under Regulation (EC) No 258/97 of the European Parliament and of the Council, in C(2009) 3149, T.C.o.t.E. Communities; Official Journal of the European Union: Brussels, , 2009.
[85]
Briand, P. Avis de l’Agence française de sécurité sanitaire des aliments relatif à l’évaluation des risques éventuels liés à l’emploi de lycopène en tant qu’ingrédient alimentaire, Afssa; Maisons-Alfort, 2005.
[86]
Schneeman, B.O. Qualified Health Claims: Letter Regarding Tomatoes and Prostate Cancer (Lycopene Health Claim Coalition)., 2005. Available from:. www.fda.gov
[87]
[88]
European-Commission. Novel food., 2018.Available from:. https://ec.europa.eu/food/safety/novel_food_en
[89]
d’Enfert, V. The Nagoya Protocol imposes new rules, in Expression Cosmétique. The global information on cosmetics and fragrances; , 2013.
[90]
Tran, T.H. Process development of Gac powder by using different enzymes and drying techniques. J. Food Eng., 2008, 85(3), 359-365.
[http://dx.doi.org/10.1016/j.jfoodeng.2007.07.029]
[91]
Mai, H.C.; Truong, V.; Debaste, F. Impact of limited drying on Momordica cochinchinensis Spreng. aril carotenoids content and antioxidant activity. J. Food Eng., 2013, 118, 358-364.
[http://dx.doi.org/10.1016/j.jfoodeng.2013.04.004]
[92]
Minh, N.P.; Dao, D.T.A. Effect of different antioxidant ratios supplemented into mixture of Gac (Momordica cochinchinensis Spreng) seed membrane-carrier to total carotene; accelerated temperature to shelf-life of Gac powder. Int. J. Eng. Res. Technol. (Ahmedabad), 2013, 2(11), 1005-1018.
[93]
Vuong, L.T.; King, J.C. A method of preserving and testing the acceptability of gac fruit oil, a good source of beta-carotene and essential fatty acids. Food Nutr. Bull., 2003, 24(2), 224-230.
[http://dx.doi.org/10.1177/156482650302400216] [PMID: 12891827]
[94]
Kha, T.C. Microencapsulation of Gac oil: Optimisation of spray drying conditions using response surface methodology. Powder Technol., 2014, 264, 298-309.
[http://dx.doi.org/10.1016/j.powtec.2014.05.053]
[95]
Kha, T.C. A storage study of encapsulated gac (Momordica cochinchinensis) oil powder and its fortification intofoods. Food Bioprod. Process., 2015, 96, 113-125.
[http://dx.doi.org/10.1016/j.fbp.2015.07.009]
[96]
Pham-Hoang, B.N.; Romero-Guido, C.; Phan-Thi, H.; Waché, Y. Encapsulation in a natural, preformed, multi-component and complex capsule: yeast cells. Appl. Microbiol. Biotechnol., 2013, 97(15), 6635-6645.
[http://dx.doi.org/10.1007/s00253-013-5044-1] [PMID: 23820556]
[97]
Pham-Hoang, B.N. Strategies to improve carotene entry into cells of Yarrowia lipolytica in a goal of encapsulation. J. Food Eng., 2018, 224, 88-94.
[http://dx.doi.org/10.1016/j.jfoodeng.2017.12.029]
[98]
Kapinova, A.; Stefanicka, P.; Kubatka, P.; Zubor, P.; Uramova, S.; Kello, M.; Mojzis, J.; Blahutova, D.; Qaradakhi, T.; Zulli, A.; Caprnda, M.; Danko, J.; Lasabova, Z.; Busselberg, D.; Kruzliak, P. Are plant-based functional foods better choice against cancer than single phytochemicals? A critical review of current breast cancer research. Biomed. Pharmacother., 2017, 96, 1465-1477.
[http://dx.doi.org/10.1016/j.biopha.2017.11.134] [PMID: 29198744]
[99]
Burton-Freeman, B.; Sesso, H.D. Whole food versus supplement: comparing the clinical evidence of tomato intake and lycopene supplementation on cardiovascular risk factors. Adv. Nutr., 2014, 5(5), 457-485.
[http://dx.doi.org/10.3945/an.114.005231] [PMID: 25469376]
[100]
Wang, C.Y.; Bai, X.Y.; Wang, C.H. Traditional Chinese medicine: a treasured natural resource of anticancer drug research and development. Am. J. Chin. Med., 2014, 42(3), 543-559.
[http://dx.doi.org/10.1142/S0192415X14500359] [PMID: 24871650]
[101]
González-Burgos, E.; Gómez-Serranillos, M.P. Terpene compounds in nature: a review of their potential antioxidant activity. Curr. Med. Chem., 2012, 19(31), 5319-5341.
[http://dx.doi.org/10.2174/092986712803833335] [PMID: 22963623]
[102]
Alves-Silva, J.M.; Zuzarte, M.; Marques, C.; Salgueiro, L.; Girao, H. Protective Effects of Terpenes on the Cardiovascular System: Current Advances and Future Perspectives. Curr. Med. Chem., 2016, 23(40), 4559-4600.
[http://dx.doi.org/10.2174/0929867323666160907123559] [PMID: 27604093]
[103]
Wang, Y.; Chung, S.J.; McCullough, M.L.; Song, W.O.; Fernandez, M.L.; Koo, S.I.; Chun, O.K. Dietary carotenoids are associated with cardiovascular disease risk biomarkers mediated by serum carotenoid concentrations. J. Nutr., 2014, 144(7), 1067-1074.
[http://dx.doi.org/10.3945/jn.113.184317] [PMID: 24744306]
[104]
Mordente, A.; Guantario, B.; Meucci, E.; Silvestrini, A.; Lombardi, E.; Martorana, G.E.; Giardina, B.; Böhm, V. Lycopene and cardiovascular diseases: an update. Curr. Med. Chem., 2011, 18(8), 1146-1163.
[http://dx.doi.org/10.2174/092986711795029717] [PMID: 21291369]
[105]
Yang, H.; Dou, Q.P. Targeting apoptosis pathway with natural terpenoids: implications for treatment of breast and prostate cancer. Curr. Drug Targets, 2010, 11(6), 733-744.
[http://dx.doi.org/10.2174/138945010791170842] [PMID: 20298150]
[106]
Palozza, P.; Parrone, N.; Simone, R.; Catalano, A. Role of lycopene in the control of ROS-mediated cell growth: implications in cancer prevention. Curr. Med. Chem., 2011, 18(12), 1846-1860.
[http://dx.doi.org/10.2174/092986711795496845] [PMID: 21466468]
[107]
Cho, K.S.; Shin, M.; Kim, S.; Lee, S.B. Recent Advances in Studies on the Therapeutic Potential of Dietary Carotenoids in Neurodegenerative Diseases. Oxid. Med. Cell. Longev., 2018.20184120458
[http://dx.doi.org/10.1155/2018/4120458] [PMID: 29849893]
[108]
Yoo, K-Y.; Park, S-Y. Terpenoids as potential anti-Alzheimer’s disease therapeutics. Molecules, 2012, 17(3), 3524-3538.
[http://dx.doi.org/10.3390/molecules17033524] [PMID: 22430119]

Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy