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Mini-Review Article

当前用于改善心血管疾病和肾脏疾病等流行病的诊断和治疗的药物纳米靶向策略

卷 20, 期 14, 2019

页: [1496 - 1504] 页: 9

弟呕挨: 10.2174/1389450120666190702162533

价格: $65

摘要

背景：在调节心血管稳态过程中，肾脏和心血管系统彼此密切相关。但是，寻找治疗和诊断心血管疾病的新方法没有考虑到这种关系，因此浪费了它们的评估结果以及其整体和综合分析所提供的优势。例如，在两种病理中均过表达的多种受体足够大，可以扩展寻找新的分子靶标和配体的范围。纳米技术提供了针对肾脏，心脏和血管的药理靶向策略，以克服传统心血管疗法的基本限制之一，这些限制与其在这些关键器官中的非特异性药效分布有关。 最新发现：用于治疗或诊断动脉粥样硬化，血栓形成，肾癌或纤维化，肾小球肾炎以及其他肾脏，心脏和血管病变的药物或造影剂纳米靶标可提高疗效，并减少副作用。这种作用之所以可能是因为，通过药理靶向，主要在所需部位发现了该药物。 综述目的：在本综述中，针对几种纳米载体的主动，被动和物理靶向策略进行了探讨，这些载体已被评估并提议用于治疗和诊断不同的心血管疾病。

关键词: 肾脏，心血管系统，治疗，诊断，纳米技术，纳米靶向。

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