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Review Article

通过肌肽结合处理活性羰基物种：我们现在所知道的

卷 27, 期 11, 2020

页: [1726 - 1743] 页: 18

弟呕挨: 10.2174/0929867326666190624094813

价格: $65

摘要

活性羰基物种是通过脂质和糖类的氧化裂解生成的亲电试剂。这类化合物已被描述为细胞信号转导的重要分子，同时发现它们的积累具有细胞毒性，因为它们可能会触发蛋白质的异常修饰（这一过程通常称为羰基化）。 在衰老，糖尿病，肥胖症，慢性肾衰竭，神经退行性疾病和心血管疾病中已显示出蛋白质的羰基化与人类疾病进展之间的相关性。但是，仍然尚不了解反应性羰基物质的命运，特别是关于负责其处置的机制以及其在疾病进展中的重要性。 在这种情况下，已经公开了一些关于活性羰基物质的I相和II相失活的数据。在II期机理的情况下，已经在体外和体内对一些更具代表性的化合物例如谷胱甘肽进行了谷胱甘肽缀合并随后处理加合物的途径。 4-羟基壬烯。 也有新的证据表明肌肽作为谷胱甘肽的内源性替代物参与了II期结合。然而，肌肽结合物的命运仍未得到很好的研究，与谷胱甘肽不同，几乎没有证据表明肌肽在体内会形成加合物。由于肌肽及其衍生物已被提议作为减轻与疾病发展有关的羰基化作用的潜在治疗剂，因此获得此类数据对于开发新药可能至关重要。 在此，我们希望回顾我们目前对反应性羰基物质与肌氨酸结合的认识以及肌氨酸结合物的处理，强调那些仍需要研究的方面，例如结合可逆性和酶辅助催化反应。

关键词: 活性羰基物质，神经变性，肌肽结合物触发异常，谷胱甘肽，疾病。

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