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Review Article

高流动性组框1：免疫调节蛋白

卷 19, 期 2, 2019

页: [100 - 109] 页: 10

弟呕挨: 10.2174/1566523219666190621111604

价格: $65

摘要

高迁移率族盒1（HMGB1）几乎存在于所有体细胞中，作为细胞核的组分。 在细胞发育过程中转录调节是必要的。 最近的研究表明，来自坏死细胞或活化的免疫细胞的细胞外HMGB1引发炎症反应，而细胞内HMGB1控制自噬和细胞凋亡之间的平衡。 此外，减少的HMGB1可以有效地介导组织再生。 因此，HMGB1被认为是炎性疾病的治疗靶标。 在这篇综述中，我们总结和讨论了HMGB1的免疫调节作用。

关键词: HMGB1，炎症反应，自噬，细胞凋亡，组织再生，NLSs。

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图形摘要

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