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当代肿瘤药物靶点

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ISSN (Print): 1568-0096
ISSN (Online): 1873-5576

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Review Article

Shcbp1在信号传导和疾病中的作用

卷 19, 期 11, 2019

页: [854 - 862] 页: 9

弟呕挨: 10.2174/1568009619666190620114928

价格: $65

摘要

Src同系物和胶原同系物（Shc）蛋白已被鉴定为与细胞表面受体相关的衔接蛋白，并已显示在信号传导和疾病中起重要作用。 Shcbp1充当Shc SH2域结合蛋白1，并参与信号转导通路的调节，例如FGF，NF-κB，MAPK / ERK，PI3K / AKT，TGF-β1/ Smad和β-catenin信号转导。 Shcbp1参与有丝分裂和减数分裂过程中的T细胞发育，下游信号转导通路的调控和胞质分裂。另外，已经证实Shcbp1与伯基特样淋巴瘤，乳腺癌，肺癌，神经胶质瘤，滑膜肉瘤，人肝细胞癌和其他疾病有关。 Shcbp1可能在肿瘤发生和发展中起重要作用。因此，本文综述了最近的研究，以讨论和解释Shcbp1在正常细胞增殖和分化，肿瘤发生和发展及其与蛋白质的相互作用中的作用。

关键词: 信号，肿瘤，疾病，肺癌，胶质瘤。

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图形摘要

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